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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2221152_22_224: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 2222289_283_466: with redox domain, from Solibacter usitatus Ellin6076 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 2221152_22_224 has N85 EQ 2222289_283_466 has N67 EQ 2221152_22_224 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2221152_22_224 has N E116 Q 2222289_283_466 has N E97 Q 2221152_22_224 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 2221152_22_224 has NE Q118 2222289_283_466 has NE Q99 2221152_22_224 and 1 similar proteins have Q aligning to 166Q 2221152_22_224: single domain, from Solibacter usitatus Ellin6076 2221152_22_2242221152_22_224: single domain, from Solibacter usitatus Ellin6076 2222289_283_466: with redox domain, from Solibacter usitatus Ellin6076 2222289_283_4662222289_283_466: with redox domain, from Solibacter usitatus Ellin6076 2221152_22_224: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2221152_22_224 single domain, from Solibacter usitatus Ellin6076 2222289_283_466: with redox domain, from Solibacter usitatus Ellin6076 (has NEQ)2222289_283_466 with redox domain, from Solibacter usitatus Ellin6076 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory