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Zoomed into a clade of 11 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11294790_78_245: tandem domain, from Planctomyces brasiliensis DSM 5305 (has NEN) 558057_88_251: tandem domain, from Pirellula sp. 1 (has NEN) 10357232_410_572: with other domain, from Coraliomargarita akajimensis DSM 45221 (has NEN) 4595334_71_236: tandem domain, from Planctomyces maris DSM 8797 (has NEN) 2760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 (has NEN) 10307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 (has NEN) 2767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 (has NEN) 6890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 (has NEN) 10343720_38_183: single domain, from Allochromatium vinosum DSM 180 (has NEN) 3723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ) 4911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 (has DQQ) BT2157 has N at position 134 (alignment position 385)N134 11294790_78_245 has N61 EN 558057_88_251 has N61 EN 10357232_410_572 has N61 EN 4595334_71_236 has N61 EN 2760313_39_201 has N61 EN 10307912_189_353 has N61 EN 2767479_46_191 has N43 EN 6890070_31_195 has N60 EN 10343720_38_183 has N42 EN 3723284_29_221 has N56 EQ 4911270_310_467 has D76 QQ 11294790_78_245 and 8 similar proteins have N aligning to 134N 3723284_29_221 has N56 aligning to 134N 4911270_310_467 has D76 aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 11294790_78_245 has N E81 N 558057_88_251 has N E81 N 10357232_410_572 has N E81 N 4595334_71_236 has N E81 N 2760313_39_201 has N E81 N 10307912_189_353 has N E83 N 2767479_46_191 has N E62 N 6890070_31_195 has N E80 N 10343720_38_183 has N E62 N 3723284_29_221 has N E75 Q 4911270_310_467 has D Q85 Q 11294790_78_245 and 8 similar proteins have E aligning to 164E 3723284_29_221 has E75 aligning to 164E 4911270_310_467 has Q85 aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11294790_78_245 has NE N83 558057_88_251 has NE N83 10357232_410_572 has NE N83 4595334_71_236 has NE N83 2760313_39_201 has NE N83 10307912_189_353 has NE N85 2767479_46_191 has NE N64 6890070_31_195 has NE N82 10343720_38_183 has NE N64 3723284_29_221 has NE Q77 4911270_310_467 has DQ Q87 11294790_78_245 and 8 similar proteins have N aligning to 166N 3723284_29_221 and 1 similar proteins have Q aligning to 166Q 0.927 0.970 11294790_78_245: tandem domain, from Planctomyces brasiliensis DSM 5305 11294790_78_24511294790_78_245: tandem domain, from Planctomyces brasiliensis DSM 5305 0.823 558057_88_251: tandem domain, from Pirellula sp. 1 558057_88_251558057_88_251: tandem domain, from Pirellula sp. 1 0.829 10357232_410_572: with other domain, from Coraliomargarita akajimensis DSM 45221 10357232_410_57210357232_410_572: with other domain, from Coraliomargarita akajimensis DSM 45221 0.324 4595334_71_236: tandem domain, from Planctomyces maris DSM 8797 4595334_71_2364595334_71_236: tandem domain, from Planctomyces maris DSM 8797 0.125 2760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 2760313_39_2012760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 10307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 10307912_189_35310307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 0.968 2767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 2767479_46_1912767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 0.813 6890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 6890070_31_1956890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 10343720_38_183: single domain, from Allochromatium vinosum DSM 180 10343720_38_18310343720_38_183: single domain, from Allochromatium vinosum DSM 180 0.607 3723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 3723284_29_2213723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 4911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 4911270_310_4674911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 11294790_78_245: tandem domain, from Planctomyces brasiliensis DSM 5305 (has NEN)11294790_78_245 tandem domain, from Planctomyces brasiliensis DSM 5305 558057_88_251: tandem domain, from Pirellula sp. 1 (has NEN)558057_88_251 tandem domain, from Pirellula sp. 1 10357232_410_572: with other domain, from Coraliomargarita akajimensis DSM 45221 (has NEN)10357232_410_572 with other domain, from Coraliomargarita akajimensis DSM 45221 4595334_71_236: tandem domain, from Planctomyces maris DSM 8797 (has NEN)4595334_71_236 tandem domain, from Planctomyces maris DSM 8797 2760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 (has NEN)2760313_39_201 tandem domain, from Blastopirellula marina DSM 3645 10307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 (has NEN)10307912_189_353 tandem domain, from Pirellula staleyi DSM 6068 2767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 (has NEN)2767479_46_191 single domain, from Flavobacteriales bacterium HTCC2170 6890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 (has NEN)6890070_31_195 single domain, from Polynucleobacter sp. QLW-P1DMWA-1 10343720_38_183: single domain, from Allochromatium vinosum DSM 180 (has NEN)10343720_38_183 single domain, from Allochromatium vinosum DSM 180 3723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ)3723284_29_221 single domain, from Parabacteroides distasonis ATCC 8503 4911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 (has DQQ)4911270_310_467 with other domain, from Gemmata obscuriglobus UQM 2246 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory