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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 (has NEN) 10307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 (has NEN) BT2157 has N at position 134 (alignment position 385)N134 2760313_39_201 has N61 EN 10307912_189_353 has N61 EN 2760313_39_201 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2760313_39_201 has N E81 N 10307912_189_353 has N E83 N 2760313_39_201 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 2760313_39_201 has NE N83 10307912_189_353 has NE N85 2760313_39_201 and 1 similar proteins have N aligning to 166N 2760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 2760313_39_2012760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 10307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 10307912_189_35310307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 2760313_39_201: tandem domain, from Blastopirellula marina DSM 3645 (has NEN)2760313_39_201 tandem domain, from Blastopirellula marina DSM 3645 10307912_189_353: tandem domain, from Pirellula staleyi DSM 6068 (has NEN)10307912_189_353 tandem domain, from Pirellula staleyi DSM 6068 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory