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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 (has NEN) 6890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 (has NEN) 10343720_38_183: single domain, from Allochromatium vinosum DSM 180 (has NEN) BT2157 has N at position 134 (alignment position 385)N134 2767479_46_191 has N43 EN 6890070_31_195 has N60 EN 10343720_38_183 has N42 EN 2767479_46_191 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2767479_46_191 has N E62 N 6890070_31_195 has N E80 N 10343720_38_183 has N E62 N 2767479_46_191 and 2 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 2767479_46_191 has NE N64 6890070_31_195 has NE N82 10343720_38_183 has NE N64 2767479_46_191 and 2 similar proteins have N aligning to 166N 2767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 2767479_46_1912767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 0.813 6890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 6890070_31_1956890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 10343720_38_183: single domain, from Allochromatium vinosum DSM 180 10343720_38_18310343720_38_183: single domain, from Allochromatium vinosum DSM 180 2767479_46_191: single domain, from Flavobacteriales bacterium HTCC2170 (has NEN)2767479_46_191 single domain, from Flavobacteriales bacterium HTCC2170 6890070_31_195: single domain, from Polynucleobacter sp. QLW-P1DMWA-1 (has NEN)6890070_31_195 single domain, from Polynucleobacter sp. QLW-P1DMWA-1 10343720_38_183: single domain, from Allochromatium vinosum DSM 180 (has NEN)10343720_38_183 single domain, from Allochromatium vinosum DSM 180 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory