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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

3723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ) 4911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 (has DQQ) BT2157 has N at position 134 (alignment position 385)N134 3723284_29_221 has N56 EQ 4911270_310_467 has D76 QQ 3723284_29_221 has N56 aligning to 134N 4911270_310_467 has D76 aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 3723284_29_221 has N E75 Q 4911270_310_467 has D Q85 Q 3723284_29_221 has E75 aligning to 164E 4911270_310_467 has Q85 aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 3723284_29_221 has NE Q77 4911270_310_467 has DQ Q87 3723284_29_221 and 1 similar proteins have Q aligning to 166Q 3723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 3723284_29_2213723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 4911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 4911270_310_4674911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 3723284_29_221: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ)3723284_29_221 single domain, from Parabacteroides distasonis ATCC 8503 4911270_310_467: with other domain, from Gemmata obscuriglobus UQM 2246 (has DQQ)4911270_310_467 with other domain, from Gemmata obscuriglobus UQM 2246 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory