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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

0.700 0.932 0.920 6004792_562_779: with other domain, from Verrucomicrobium spinosum DSM 4136 0.893 7352115_10_283: single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 10307627_52_286: single domain, from Pirellula staleyi DSM 6068 11129631_48_250: single domain, from Aquiflexum balticum BA160, DSM 16537 0.884 4613166_24_177: single domain, from Lentisphaera araneosa HTCC2155 0.834 6251748_28_203: single domain, from Chthoniobacter flavus Ellin428 11136081_27_193: single domain, from Haliscomenobacter hydrossis O, DSM 1100 1 /site with other domain, from Verrucomicrobium spinosum DSM 4136 6004792_562_779 with other domain, from Verrucomicrobium spinosum DSM 4136 single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 7352115_10_283 single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 single domain, from Pirellula staleyi DSM 6068 10307627_52_286 single domain, from Pirellula staleyi DSM 6068 single domain, from Aquiflexum balticum BA160, DSM 16537 11129631_48_250 single domain, from Aquiflexum balticum BA160, DSM 16537 single domain, from Lentisphaera araneosa HTCC2155 4613166_24_177 single domain, from Lentisphaera araneosa HTCC2155 single domain, from Chthoniobacter flavus Ellin428 6251748_28_203 single domain, from Chthoniobacter flavus Ellin428 single domain, from Haliscomenobacter hydrossis O, DSM 1100 11136081_27_193 single domain, from Haliscomenobacter hydrossis O, DSM 1100 download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory