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Zoomed into a clade of 4 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6004792_562_779: with other domain, from Verrucomicrobium spinosum DSM 4136 (has DQL) 7352115_10_283: single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 (has DQL) 10307627_52_286: single domain, from Pirellula staleyi DSM 6068 (has CQM) 11129631_48_250: single domain, from Aquiflexum balticum BA160, DSM 16537 (has NQE) BT2157 has N at position 134 (alignment position 385)N134 6004792_562_779 has D76 QL 7352115_10_283 has D97 QL 10307627_52_286 has C72 QM 11129631_48_250 has N70 QE 6004792_562_779 has D76 aligning to 134D 7352115_10_283 has D97 aligning to 134D 10307627_52_286 has C72 aligning to 134C 11129631_48_250 has N70 aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 6004792_562_779 has D Q91 L 7352115_10_283 has D Q113 L 10307627_52_286 has C Q87 M 11129631_48_250 has N Q85 E 6004792_562_779 and 3 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 6004792_562_779 has DQ L93 7352115_10_283 has DQ L115 10307627_52_286 has CQ M89 11129631_48_250 has NQ E87 6004792_562_779 has L93 aligning to 166L 7352115_10_283 has L115 aligning to 166L 10307627_52_286 has M89 aligning to 166M 11129631_48_250 has E87 aligning to 166E 0.920 6004792_562_779: with other domain, from Verrucomicrobium spinosum DSM 4136 6004792_562_7796004792_562_779: with other domain, from Verrucomicrobium spinosum DSM 4136 0.893 7352115_10_283: single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 7352115_10_2837352115_10_283: single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 10307627_52_286: single domain, from Pirellula staleyi DSM 6068 10307627_52_28610307627_52_286: single domain, from Pirellula staleyi DSM 6068 11129631_48_250: single domain, from Aquiflexum balticum BA160, DSM 16537 11129631_48_25011129631_48_250: single domain, from Aquiflexum balticum BA160, DSM 16537 6004792_562_779: with other domain, from Verrucomicrobium spinosum DSM 4136 (has DQL)6004792_562_779 with other domain, from Verrucomicrobium spinosum DSM 4136 7352115_10_283: single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 (has DQL)7352115_10_283 single domain, near sugar dehydrogenase, from Arthrobacter chlorophenolicus A6 10307627_52_286: single domain, from Pirellula staleyi DSM 6068 (has CQM)10307627_52_286 single domain, from Pirellula staleyi DSM 6068 11129631_48_250: single domain, from Aquiflexum balticum BA160, DSM 16537 (has NQE)11129631_48_250 single domain, from Aquiflexum balticum BA160, DSM 16537 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory