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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6251748_28_203: single domain, from Chthoniobacter flavus Ellin428 (has DQQ) 11136081_27_193: single domain, from Haliscomenobacter hydrossis O, DSM 1100 (has DQG) BT2157 has N at position 134 (alignment position 385)N134 6251748_28_203 has D67 QQ 11136081_27_193 has D64 QG 6251748_28_203 and 1 similar proteins have D aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 6251748_28_203 has D Q78 Q 11136081_27_193 has D Q77 G 6251748_28_203 and 1 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 6251748_28_203 has DQ Q80 11136081_27_193 has DQ G79 6251748_28_203 has Q80 aligning to 166Q 11136081_27_193 has G79 aligning to 166G 6251748_28_203: single domain, from Chthoniobacter flavus Ellin428 6251748_28_2036251748_28_203: single domain, from Chthoniobacter flavus Ellin428 11136081_27_193: single domain, from Haliscomenobacter hydrossis O, DSM 1100 11136081_27_19311136081_27_193: single domain, from Haliscomenobacter hydrossis O, DSM 1100 6251748_28_203: single domain, from Chthoniobacter flavus Ellin428 (has DQQ)6251748_28_203 single domain, from Chthoniobacter flavus Ellin428 11136081_27_193: single domain, from Haliscomenobacter hydrossis O, DSM 1100 (has DQG)11136081_27_193 single domain, from Haliscomenobacter hydrossis O, DSM 1100 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory