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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2224729_30_207: single domain, from Solibacter usitatus Ellin6076 (has NQE) 7471529_22_194: single domain, from Chitinophaga pinensis DSM 2588 (has NQE) BT2157 has N at position 134 (alignment position 385)N134 2224729_30_207 has N63 QE 7471529_22_194 has N62 QE 2224729_30_207 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2224729_30_207 has N Q84 E 7471529_22_194 has N Q80 E 2224729_30_207 and 1 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 2224729_30_207 has NQ E86 7471529_22_194 has NQ E82 2224729_30_207 and 1 similar proteins have E aligning to 166E 2224729_30_207: single domain, from Solibacter usitatus Ellin6076 2224729_30_2072224729_30_207: single domain, from Solibacter usitatus Ellin6076 7471529_22_194: single domain, from Chitinophaga pinensis DSM 2588 7471529_22_1947471529_22_194: single domain, from Chitinophaga pinensis DSM 2588 2224729_30_207: single domain, from Solibacter usitatus Ellin6076 (has NQE)2224729_30_207 single domain, from Solibacter usitatus Ellin6076 7471529_22_194: single domain, from Chitinophaga pinensis DSM 2588 (has NQE)7471529_22_194 single domain, from Chitinophaga pinensis DSM 2588 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory