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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.827 2224729_30_207: single domain, from Solibacter usitatus Ellin6076 7471529_22_194: single domain, from Chitinophaga pinensis DSM 2588 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Solibacter usitatus Ellin6076 2224729_30_207 single domain, from Solibacter usitatus Ellin6076 2224729_30_207 at #155: Q1 2224729_30_207 at #155: Q1 Q 2224729_30_207 at #156: W2 2224729_30_207 at #156: W2 W 2224729_30_207 at #157: V3 2224729_30_207 at #157: V3 V 2224729_30_207 at #158: Q4 2224729_30_207 at #158: Q4 Q 2224729_30_207 at #159: L5 2224729_30_207 at #159: L5 L 2224729_30_207 at #160: F6 2224729_30_207 at #160: F6 F 2224729_30_207 at #162: N7 2224729_30_207 at #162: N7 N 2224729_30_207 at #164: G8 2224729_30_207 at #164: G8 G 2224729_30_207 at #165: K9 2224729_30_207 at #165: K9 K 2224729_30_207 at #168: D10 2224729_30_207 at #168: D10 D 2224729_30_207 at #169: L11 2224729_30_207 at #169: L11 L 2224729_30_207 at #171: S12 2224729_30_207 at #171: S12 S 2224729_30_207 at #172: G13 2224729_30_207 at #172: G13 G 2224729_30_207 at #180: W14 2224729_30_207 at #180: W14 W 2224729_30_207 at #181: V15 2224729_30_207 at #181: V15 V 2224729_30_207 at #185: N16 2224729_30_207 at #185: N16 N 2224729_30_207 at #186: V17 2224729_30_207 at #186: V17 V 2224729_30_207 at #187: G18 2224729_30_207 at #187: G18 G 2224729_30_207 at #188 2224729_30_207 at #188 - 2224729_30_207 at #189 2224729_30_207 at #189 - 2224729_30_207 at #190 2224729_30_207 at #190 - 2224729_30_207 at #191 2224729_30_207 at #191 - 2224729_30_207 at #195: H19 2224729_30_207 at #195: H19 H 2224729_30_207 at #196: E20 2224729_30_207 at #196: E20 E 2224729_30_207 at #197: K21 2224729_30_207 at #197: K21 K 2224729_30_207 at #198: W22 2224729_30_207 at #198: W22 W 2224729_30_207 at #235: T23 2224729_30_207 at #235: T23 T 2224729_30_207 at #236: V24 2224729_30_207 at #236: V24 V 2224729_30_207 at #237: E25 2224729_30_207 at #237: E25 E 2224729_30_207 at #238: D26 2224729_30_207 at #238: D26 D 2224729_30_207 at #240: G27 2224729_30_207 at #240: G27 G 2224729_30_207 at #268: T28 2224729_30_207 at #268: T28 T 2224729_30_207 at #269: I29 2224729_30_207 at #269: I29 I 2224729_30_207 at #270: H30 2224729_30_207 at #270: H30 H 2224729_30_207 at #294: Q32 2224729_30_207 at #294: Q32 Q 2224729_30_207 at #295: G33 2224729_30_207 at #295: G33 G 2224729_30_207 at #296: V34 2224729_30_207 at #296: V34 V 2224729_30_207 at #297: T35 2224729_30_207 at #297: T35 T 2224729_30_207 at #298: K36 2224729_30_207 at #298: K36 K 2224729_30_207 at #299: E37 2224729_30_207 at #299: E37 E 2224729_30_207 at #300: Y38 2224729_30_207 at #300: Y38 Y 2224729_30_207 at #301: G39 2224729_30_207 at #301: G39 G 2224729_30_207 at #303: Y40 2224729_30_207 at #303: Y40 Y 2224729_30_207 at #304: L41 2224729_30_207 at #304: L41 L 2224729_30_207 at #305: R42 2224729_30_207 at #305: R42 R 2224729_30_207 at #306: T43 2224729_30_207 at #306: T43 T 2224729_30_207 at #312: E44 2224729_30_207 at #312: E44 E 2224729_30_207 at #318: K45 2224729_30_207 at #318: K45 K 2224729_30_207 at #321: Q46 2224729_30_207 at #321: Q46 Q 2224729_30_207 at #322: Y47 2224729_30_207 at #322: Y47 Y 2224729_30_207 at #324: K48 2224729_30_207 at #324: K48 K 2224729_30_207 at #326: D49 2224729_30_207 at #326: D49 D 2224729_30_207 at #327: F50 2224729_30_207 at #327: F50 F 2224729_30_207 at #328: W51 2224729_30_207 at #328: W51 W 2224729_30_207 at #329: L52 2224729_30_207 at #329: L52 L 2224729_30_207 at #330: S53 2224729_30_207 at #330: S53 S 2224729_30_207 at #331: I54 2224729_30_207 at #331: I54 I 2224729_30_207 at #332: R55 2224729_30_207 at #332: R55 R 2224729_30_207 at #333: F56 2224729_30_207 at #333: F56 F 2224729_30_207 at #334: K57 2224729_30_207 at #334: K57 K 2224729_30_207 at #335: C58 2224729_30_207 at #335: C58 C 2224729_30_207 at #351: E59 2224729_30_207 at #351: E59 E 2224729_30_207 at #352: D60 2224729_30_207 at #352: D60 D 2224729_30_207 at #354: D61 2224729_30_207 at #354: D61 D 2224729_30_207 at #355: G62 2224729_30_207 at #355: G62 G 2224729_30_207 at #385: N63 2224729_30_207 at #385: N63 N 2224729_30_207 at #386: S64 2224729_30_207 at #386: S64 S 2224729_30_207 at #387: G65 2224729_30_207 at #387: G65 G 2224729_30_207 at #388: V66 2224729_30_207 at #388: V66 V 2224729_30_207 at #389: Y67 2224729_30_207 at #389: Y67 Y 2224729_30_207 at #390: F68 2224729_30_207 at #390: F68 F 2224729_30_207 at #391: H69 2224729_30_207 at #391: H69 H 2224729_30_207 at #392: T70 2224729_30_207 at #392: T70 T 2224729_30_207 at #393: D71 2224729_30_207 at #393: D71 D 2224729_30_207 at #423: K73 2224729_30_207 at #423: K73 K 2224729_30_207 at #424: P74 2224729_30_207 at #424: P74 P 2224729_30_207 at #425: G75 2224729_30_207 at #425: G75 G 2224729_30_207 at #426: T76 2224729_30_207 at #426: T76 T 2224729_30_207 at #430: V77 2224729_30_207 at #430: V77 V 2224729_30_207 at #431: D78 2224729_30_207 at #431: D78 D 2224729_30_207 at #432: V79 2224729_30_207 at #432: V79 V 2224729_30_207 at #433: S80 2224729_30_207 at #433: S80 S 2224729_30_207 at #434: K81 2224729_30_207 at #434: K81 K 2224729_30_207 at #435: G82 2224729_30_207 at #435: G82 G 2224729_30_207 at #436: M83 2224729_30_207 at #436: M83 M 2224729_30_207 at #438: Q84 2224729_30_207 at #438: Q84 Q 2224729_30_207 at #439: F85 2224729_30_207 at #439: F85 F 2224729_30_207 at #440: E86 2224729_30_207 at #440: E86 E 2224729_30_207 at #441: I87 2224729_30_207 at #441: I87 I 2224729_30_207 at #442: D88 2224729_30_207 at #442: D88 D 2224729_30_207 at #443: R89 2224729_30_207 at #443: R89 R 2224729_30_207 at #450 2224729_30_207 at #450 - 2224729_30_207 at #451 2224729_30_207 at #451 - 2224729_30_207 at #452 2224729_30_207 at #452 - 2224729_30_207 at #453 2224729_30_207 at #453 - 2224729_30_207 at #475 2224729_30_207 at #475 - 2224729_30_207 at #476: T90 2224729_30_207 at #476: T90 T 2224729_30_207 at #477: L91 2224729_30_207 at #477: L91 L 2224729_30_207 at #478: N92 2224729_30_207 at #478: N92 N 2224729_30_207 at #479: H93 2224729_30_207 at #479: H93 H 2224729_30_207 at #480: H94 2224729_30_207 at #480: H94 H 2224729_30_207 at #481: N95 2224729_30_207 at #481: N95 N 2224729_30_207 at #482: G96 2224729_30_207 at #482: G96 G 2224729_30_207 at #483: G97 2224729_30_207 at #483: G97 G 2224729_30_207 at #484: L98 2224729_30_207 at #484: L98 L 2224729_30_207 at #485: Y99 2224729_30_207 at #485: Y99 Y 2224729_30_207 at #486: G100 2224729_30_207 at #486: G100 G 2224729_30_207 at #487: D101 2224729_30_207 at #487: D101 D 2224729_30_207 at #530: I106 2224729_30_207 at #530: I106 I 2224729_30_207 at #532 2224729_30_207 at #532 - 2224729_30_207 at #533 2224729_30_207 at #533 - 2224729_30_207 at #534 2224729_30_207 at #534 - 2224729_30_207 at #535: A107 2224729_30_207 at #535: A107 A 2224729_30_207 at #544: P111 2224729_30_207 at #544: P111 P 2224729_30_207 at #545: E112 2224729_30_207 at #545: E112 E 2224729_30_207 at #548: Y113 2224729_30_207 at #548: Y113 Y 2224729_30_207 at #549: E114 2224729_30_207 at #549: E114 E 2224729_30_207 at #550: Q115 2224729_30_207 at #550: Q115 Q 2224729_30_207 at #551: V116 2224729_30_207 at #551: V116 V 2224729_30_207 at #552: I117 2224729_30_207 at #552: I117 I 2224729_30_207 at #553: R118 2224729_30_207 at #553: R118 R 2224729_30_207 at #554: P119 2224729_30_207 at #554: P119 P 2224729_30_207 at #555: T120 2224729_30_207 at #555: T120 T 2224729_30_207 at #556: D121 2224729_30_207 at #556: D121 D 2224729_30_207 at #557: W122 2224729_30_207 at #557: W122 W 2224729_30_207 at #558: N123 2224729_30_207 at #558: N123 N 2224729_30_207 at #559: E124 2224729_30_207 at #559: E124 E 2224729_30_207 at #560: F125 2224729_30_207 at #560: F125 F 2224729_30_207 at #561: L126 2224729_30_207 at #561: L126 L 2224729_30_207 at #562: L127 2224729_30_207 at #562: L127 L 2224729_30_207 at #565: K128 2224729_30_207 at #565: K128 K 2224729_30_207 at #566: V129 2224729_30_207 at #566: V129 V 2224729_30_207 at #568: E130 2224729_30_207 at #568: E130 E 2224729_30_207 at #570: G131 2224729_30_207 at #570: G131 G 2224729_30_207 at #571: N132 2224729_30_207 at #571: N132 N 2224729_30_207 at #572: H133 2224729_30_207 at #572: H133 H 2224729_30_207 at #588: M134 2224729_30_207 at #588: M134 M 2224729_30_207 at #589: V135 2224729_30_207 at #589: V135 V 2224729_30_207 at #592: A136 2224729_30_207 at #592: A136 A 2224729_30_207 at #594: I137 2224729_30_207 at #594: I137 I 2224729_30_207 at #595: L138 2224729_30_207 at #595: L138 L 2224729_30_207 at #596: N139 2224729_30_207 at #596: N139 N 2224729_30_207 at #598: G140 2224729_30_207 at #598: G140 G 2224729_30_207 at #599: I141 2224729_30_207 at #599: I141 I 2224729_30_207 at #600: A142 2224729_30_207 at #600: A142 A 2224729_30_207 at #601: I143 2224729_30_207 at #601: I143 I 2224729_30_207 at #602: I144 2224729_30_207 at #602: I144 I 2224729_30_207 at #603: D145 2224729_30_207 at #603: D145 D 2224729_30_207 at #604: F146 2224729_30_207 at #604: F146 F 2224729_30_207 at #605: T147 2224729_30_207 at #605: T147 T 2224729_30_207 at #606: D148 2224729_30_207 at #606: D148 D 2224729_30_207 at #607: P149 2224729_30_207 at #607: P149 P 2224729_30_207 at #608: T150 2224729_30_207 at #608: T150 T 2224729_30_207 at #609: P151 2224729_30_207 at #609: P151 P 2224729_30_207 at #610: K152 2224729_30_207 at #610: K152 K 2224729_30_207 at #611: S153 2224729_30_207 at #611: S153 S 2224729_30_207 at #612 2224729_30_207 at #612 - 2224729_30_207 at #613 2224729_30_207 at #613 - 2224729_30_207 at #614 2224729_30_207 at #614 - 2224729_30_207 at #615 2224729_30_207 at #615 - 2224729_30_207 at #616 2224729_30_207 at #616 - 2224729_30_207 at #640 2224729_30_207 at #640 - 2224729_30_207 at #641 2224729_30_207 at #641 - 2224729_30_207 at #642 2224729_30_207 at #642 - 2224729_30_207 at #643: F154 2224729_30_207 at #643: F154 F 2224729_30_207 at #644: D155 2224729_30_207 at #644: D155 D 2224729_30_207 at #645: G156 2224729_30_207 at #645: G156 G 2224729_30_207 at #646: Y157 2224729_30_207 at #646: Y157 Y 2224729_30_207 at #647: I158 2224729_30_207 at #647: I158 I 2224729_30_207 at #648: A159 2224729_30_207 at #648: A159 A 2224729_30_207 at #649: L160 2224729_30_207 at #649: L160 L 2224729_30_207 at #650: Q161 2224729_30_207 at #650: Q161 Q 2224729_30_207 at #653: L162 2224729_30_207 at #653: L162 L 2224729_30_207 at #654: H163 2224729_30_207 at #654: H163 H 2224729_30_207 at #655: S164 2224729_30_207 at #655: S164 S 2224729_30_207 at #668: G168 2224729_30_207 at #668: G168 G 2224729_30_207 at #689: N169 2224729_30_207 at #689: N169 N 2224729_30_207 at #690: M170 2224729_30_207 at #690: M170 M 2224729_30_207 at #691: R171 2224729_30_207 at #691: R171 R 2224729_30_207 at #694: F172 2224729_30_207 at #694: F172 F 2224729_30_207 at #695: K173 2224729_30_207 at #695: K173 K 2224729_30_207 at #696: D174 2224729_30_207 at #696: D174 D 2224729_30_207 at #697: I175 2224729_30_207 at #697: I175 I 2224729_30_207 at #698: Y176 2224729_30_207 at #698: Y176 Y 2224729_30_207 at #699: L177 2224729_30_207 at #699: L177 L 2224729_30_207 at #700: R178 2224729_30_207 at #700: R178 R single domain, from Chitinophaga pinensis DSM 2588 7471529_22_194 single domain, from Chitinophaga pinensis DSM 2588 7471529_22_194 at #155 7471529_22_194 at #155 - 7471529_22_194 at #156 7471529_22_194 at #156 - 7471529_22_194 at #157: Q1 7471529_22_194 at #157: Q1 Q 7471529_22_194 at #158: S2 7471529_22_194 at #158: S2 S 7471529_22_194 at #159: L3 7471529_22_194 at #159: L3 L 7471529_22_194 at #160: F4 7471529_22_194 at #160: F4 F 7471529_22_194 at #162: N5 7471529_22_194 at #162: N5 N 7471529_22_194 at #164: G6 7471529_22_194 at #164: G6 G 7471529_22_194 at #165: K7 7471529_22_194 at #165: K7 K 7471529_22_194 at #168: N8 7471529_22_194 at #168: N8 N 7471529_22_194 at #169: L9 7471529_22_194 at #169: L9 L 7471529_22_194 at #171: D10 7471529_22_194 at #171: D10 D 7471529_22_194 at #172: G11 7471529_22_194 at #172: G11 G 7471529_22_194 at #180: W12 7471529_22_194 at #180: W12 W 7471529_22_194 at #181: K13 7471529_22_194 at #181: K13 K 7471529_22_194 at #185: V14 7471529_22_194 at #185: V14 V 7471529_22_194 at #186: Y15 7471529_22_194 at #186: Y15 Y 7471529_22_194 at #187: G16 7471529_22_194 at #187: G16 G 7471529_22_194 at #188: T17 7471529_22_194 at #188: T17 T 7471529_22_194 at #189: E18 7471529_22_194 at #189: E18 E 7471529_22_194 at #190 7471529_22_194 at #190 - 7471529_22_194 at #191 7471529_22_194 at #191 - 7471529_22_194 at #195 7471529_22_194 at #195 - 7471529_22_194 at #196 7471529_22_194 at #196 - 7471529_22_194 at #197: K19 7471529_22_194 at #197: K19 K 7471529_22_194 at #198: W20 7471529_22_194 at #198: W20 W 7471529_22_194 at #235: Y21 7471529_22_194 at #235: Y21 Y 7471529_22_194 at #236: V22 7471529_22_194 at #236: V22 V 7471529_22_194 at #237: D23 7471529_22_194 at #237: D23 D 7471529_22_194 at #238: N24 7471529_22_194 at #238: N24 N 7471529_22_194 at #240: G25 7471529_22_194 at #240: G25 G 7471529_22_194 at #268: T26 7471529_22_194 at #268: T26 T 7471529_22_194 at #269: L27 7471529_22_194 at #269: L27 L 7471529_22_194 at #270: V28 7471529_22_194 at #270: V28 V 7471529_22_194 at #294: S31 7471529_22_194 at #294: S31 S 7471529_22_194 at #295: G32 7471529_22_194 at #295: G32 G 7471529_22_194 at #296: P33 7471529_22_194 at #296: P33 P 7471529_22_194 at #297: D34 7471529_22_194 at #297: D34 D 7471529_22_194 at #298: K35 7471529_22_194 at #298: K35 K 7471529_22_194 at #299: E36 7471529_22_194 at #299: E36 E 7471529_22_194 at #300: Y37 7471529_22_194 at #300: Y37 Y 7471529_22_194 at #301: G38 7471529_22_194 at #301: G38 G 7471529_22_194 at #303: Y39 7471529_22_194 at #303: Y39 Y 7471529_22_194 at #304: L40 7471529_22_194 at #304: L40 L 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory