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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11293622_25_202: single domain, from Planctomyces brasiliensis DSM 5305 (has NQE) 11269564_221_397: tandem domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQE) 559162_234_438: tandem domain, from Pirellula sp. 1 (has DQE) 556011_250_415: tandem domain, from Pirellula sp. 1 (has NQE) THTE_1561: endoxanthanase from Thermogutta terrifontis (has NQE) BT2157 has N at position 134 (alignment position 385)N134 11293622_25_202 has N64 QE 11269564_221_397 has N64 QE 559162_234_438 has D65 QE 556011_250_415 has N45 QE THTE_1561 has N97 QE 11293622_25_202 has N64 aligning to 134N 11269564_221_397 has N64 aligning to 134N 559162_234_438 has D65 aligning to 134D 556011_250_415 has N45 aligning to 134N THTE_1561 has N97 aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11293622_25_202 has N Q84 E 11269564_221_397 has N Q85 E 559162_234_438 has D Q85 E 556011_250_415 has N Q65 E THTE_1561 has N Q116 E 11293622_25_202 and 4 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11293622_25_202 has NQ E86 11269564_221_397 has NQ E87 559162_234_438 has DQ E87 556011_250_415 has NQ E67 THTE_1561 has NQ E118 11293622_25_202 and 4 similar proteins have E aligning to 166E 0.855 11293622_25_202: single domain, from Planctomyces brasiliensis DSM 5305 11293622_25_20211293622_25_202: single domain, from Planctomyces brasiliensis DSM 5305 0.607 0.532 11269564_221_397: tandem domain, from Isosphaera pallida IS1B, ATCC 43644 11269564_221_39711269564_221_397: tandem domain, from Isosphaera pallida IS1B, ATCC 43644 559162_234_438: tandem domain, from Pirellula sp. 1 559162_234_438559162_234_438: tandem domain, from Pirellula sp. 1 556011_250_415: tandem domain, from Pirellula sp. 1 556011_250_415556011_250_415: tandem domain, from Pirellula sp. 1 THTE_1561: endoxanthanase from Thermogutta terrifontis THTE_1561THTE_1561: endoxanthanase from Thermogutta terrifontis 11293622_25_202: single domain, from Planctomyces brasiliensis DSM 5305 (has NQE)11293622_25_202 single domain, from Planctomyces brasiliensis DSM 5305 11269564_221_397: tandem domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQE)11269564_221_397 tandem domain, from Isosphaera pallida IS1B, ATCC 43644 559162_234_438: tandem domain, from Pirellula sp. 1 (has DQE)559162_234_438 tandem domain, from Pirellula sp. 1 556011_250_415: tandem domain, from Pirellula sp. 1 (has NQE)556011_250_415 tandem domain, from Pirellula sp. 1 THTE_1561: endoxanthanase from Thermogutta terrifontis (has NQE)THTE_1561 endoxanthanase from Thermogutta terrifontis 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory