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Zoomed into a clade of 26 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10356339_57_245: single domain, from Coraliomargarita akajimensis DSM 45221 (has NED) 554685_116_314: with other domain, from Pirellula sp. 1 (has NQD) 2220515_8_228: single domain, from Solibacter usitatus Ellin6076 (has GQD) 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 (has NQD) 2760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 (has NQD) 556853_51_260: single domain, from Pirellula sp. 1 (has NQE) 6004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 (has NQE) 6254877_31_231: single domain, from Chthoniobacter flavus Ellin428 (has NQE) 6253153_22_242: single domain, from Chthoniobacter flavus Ellin428 (has NQD) 559512_79_278: single domain, from Pirellula sp. 1 (has NQD) 11293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD) 554416_28_225: with redox domain, from Pirellula sp. 1 (has NQD) 4611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 (has NQD) 11296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD) 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 (has NQD) 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 (has NQD) 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 (has NQD) 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD) 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 (has NQD) 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has NQD) 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 (has NQD) 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD) 560752_63_281: single domain, from Pirellula sp. 1 (has NQD) 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD) 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 (has NQD) 10267460_32_215: single domain, from Spirosoma linguale DSM 74 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 BT2157 has N at position 134 (alignment position 385)N134" 10356339_57_245 has N65 ED 554685_116_314 has N65 QD 2220515_8_228 has G66 QD 11141775_41_262 has N67 QD 2760957_28_228 has N66 QD 556853_51_260 has N66 QE 6004807_27_244 has N66 QE 6254877_31_231 has N64 QE 6253153_22_242 has N72 QD 559512_79_278 has N64 QD 11293204_36_238 has N69 QD 554416_28_225 has N65 QD 4611874_988_1186 has N65 QD 11296383_24_224 has N67 QD 11227501_33_203 has N65 QD 2761067_1173_1341 has N62 QD 4911453_35_208 has N56 QD 11272043_27_202 has N65 QD 6378172_468_664 has N71 QD 6003860_25_205 has N66 QD 7396463_28_209 has N67 QD 2761156_23_206 has N65 QD 560752_63_281 has N65 QD 11268538_332_511 has N66 QD 6250794_21_205 has N70 QD 10267460_32_215 has N73 QD 10356339_57_245 has N65 aligning to 134N 554685_116_314 has N65 aligning to 134N 2220515_8_228 has G66 aligning to 134G 11141775_41_262 has N67 aligning to 134N 2760957_28_228 and 9 similar proteins have N aligning to 134N 11227501_33_203 and 11 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 BT2157 has E at position 164 (alignment position 438)E164" 10356339_57_245 has N E93 D 554685_116_314 has N Q87 D 2220515_8_228 has G Q104 D 11141775_41_262 has N Q88 D 2760957_28_228 has N Q85 D 556853_51_260 has N Q91 E 6004807_27_244 has N Q87 E 6254877_31_231 has N Q83 E 6253153_22_242 has N Q93 D 559512_79_278 has N Q85 D 11293204_36_238 has N Q88 D 554416_28_225 has N Q86 D 4611874_988_1186 has N Q86 D 11296383_24_224 has N Q89 D 11227501_33_203 has N Q83 D 2761067_1173_1341 has N Q81 D 4911453_35_208 has N Q81 D 11272043_27_202 has N Q84 D 6378172_468_664 has N Q94 D 6003860_25_205 has N Q87 D 7396463_28_209 has N Q88 D 2761156_23_206 has N Q85 D 560752_63_281 has N Q90 D 11268538_332_511 has N Q86 D 6250794_21_205 has N Q90 D 10267460_32_215 has N Q91 D 10356339_57_245 has E93 aligning to 164E 554685_116_314 and 12 similar proteins have Q aligning to 164Q 11227501_33_203 and 11 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 BT2157 has Q at position 166 (alignment position 440)Q166" 10356339_57_245 has NE D95 554685_116_314 has NQ D89 2220515_8_228 has GQ D106 11141775_41_262 has NQ D90 2760957_28_228 has NQ D87 556853_51_260 has NQ E93 6004807_27_244 has NQ E89 6254877_31_231 has NQ E85 6253153_22_242 has NQ D95 559512_79_278 has NQ D87 11293204_36_238 has NQ D90 554416_28_225 has NQ D88 4611874_988_1186 has NQ D88 11296383_24_224 has NQ D91 11227501_33_203 has NQ D85 2761067_1173_1341 has NQ D83 4911453_35_208 has NQ D83 11272043_27_202 has NQ D86 6378172_468_664 has NQ D96 6003860_25_205 has NQ D89 7396463_28_209 has NQ D90 2761156_23_206 has NQ D87 560752_63_281 has NQ D92 11268538_332_511 has NQ D88 6250794_21_205 has NQ D92 10267460_32_215 has NQ D93 10356339_57_245 has D95 aligning to 166D 554685_116_314 has D89 aligning to 166D 2220515_8_228 and 1 similar proteins have D aligning to 166D 2760957_28_228 has D87 aligning to 166D 556853_51_260 and 2 similar proteins have E aligning to 166E 6253153_22_242 has D95 aligning to 166D 559512_79_278 has D87 aligning to 166D 11293204_36_238 and 3 similar proteins have D aligning to 166D 11227501_33_203 and 11 similar proteins have D aligning to 166D 0.798 10356339_57_245: single domain, from Coraliomargarita akajimensis DSM 45221 10356339_57_24510356339_57_245: single domain, from Coraliomargarita akajimensis DSM 45221 0.831 554685_116_314: with other domain, from Pirellula sp. 1 554685_116_314554685_116_314: with other domain, from Pirellula sp. 1 0.913 0.871 2220515_8_228: single domain, from Solibacter usitatus Ellin6076 2220515_8_2282220515_8_228: single domain, from Solibacter usitatus Ellin6076 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 11141775_41_26211141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 0.742 0.774 0.577 2760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 2760957_28_2282760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 0.920 0.941 0.518 556853_51_260: single domain, from Pirellula sp. 1 556853_51_260556853_51_260: single domain, from Pirellula sp. 1 6004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 6004807_27_2446004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 6254877_31_231: single domain, from Chthoniobacter flavus Ellin428 6254877_31_2316254877_31_231: single domain, from Chthoniobacter flavus Ellin428 6253153_22_242: single domain, from Chthoniobacter flavus Ellin428 6253153_22_2426253153_22_242: single domain, from Chthoniobacter flavus Ellin428 559512_79_278: single domain, from Pirellula sp. 1 559512_79_278559512_79_278: single domain, from Pirellula sp. 1 0.936 11293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 11293204_36_23811293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 0.887 0.870 554416_28_225: with redox domain, from Pirellula sp. 1 554416_28_225554416_28_225: with redox domain, from Pirellula sp. 1 4611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 4611874_988_11864611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 11296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 11296383_24_22411296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 0.880 0.809 0.707 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 11227501_33_20311227501_33_203: single domain, from Cyclobacterium marinum DSM 745 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 2761067_1173_13412761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 0.866 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 4911453_35_2084911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 11272043_27_20211272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 0.811 0.719 0.489 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 6378172_468_6646378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 0.861 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 6003860_25_2056003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 7396463_28_2097396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 0.910 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 2761156_23_2062761156_23_206: single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 560752_63_281560752_63_281: single domain, from Pirellula sp. 1 0.551 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 11268538_332_51111268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 0.513 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 6250794_21_2056250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 10267460_32_215: single domain, from Spirosoma linguale DSM 74 10267460_32_21510267460_32_215: single domain, from Spirosoma linguale DSM 74 10356339_57_245: single domain, from Coraliomargarita akajimensis DSM 45221 (has NED)10356339_57_245 single domain, from Coraliomargarita akajimensis DSM 45221 554685_116_314: with other domain, from Pirellula sp. 1 (has NQD)554685_116_314 with other domain, from Pirellula sp. 1 2220515_8_228: single domain, from Solibacter usitatus Ellin6076 (has GQD)2220515_8_228 single domain, from Solibacter usitatus Ellin6076 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 (has NQD)11141775_41_262 single domain, from Runella slithyformis LSU4, DSM 19594 2760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 (has NQD)2760957_28_228 with redox domain, from Blastopirellula marina DSM 3645 556853_51_260: single domain, from Pirellula sp. 1 (has NQE)556853_51_260 single domain, from Pirellula sp. 1 6004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 (has NQE)6004807_27_244 single domain, from Verrucomicrobium spinosum DSM 4136 6254877_31_231: single domain, from Chthoniobacter flavus Ellin428 (has NQE)6254877_31_231 single domain, from Chthoniobacter flavus Ellin428 6253153_22_242: single domain, from Chthoniobacter flavus Ellin428 (has NQD)6253153_22_242 single domain, from Chthoniobacter flavus Ellin428 559512_79_278: single domain, from Pirellula sp. 1 (has NQD)559512_79_278 single domain, from Pirellula sp. 1 11293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD)11293204_36_238 with redox domain, from Planctomyces brasiliensis DSM 5305 554416_28_225: with redox domain, from Pirellula sp. 1 (has NQD)554416_28_225 with redox domain, from Pirellula sp. 1 4611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 (has NQD)4611874_988_1186 with redox domain, from Lentisphaera araneosa HTCC2155 11296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD)11296383_24_224 with redox domain, from Planctomyces brasiliensis DSM 5305 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 (has NQD)11227501_33_203 single domain, from Cyclobacterium marinum DSM 745 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 (has NQD)2761067_1173_1341 with redox domain, from Blastopirellula marina DSM 3645 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 (has NQD)4911453_35_208 single domain, from Gemmata obscuriglobus UQM 2246 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD)11272043_27_202 single domain, from Isosphaera pallida IS1B, ATCC 43644 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 (has NQD)6378172_468_664 with other domain, from Bacteroides cellulosilyticus DSM 14838 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has NQD)6003860_25_205 with redox domain, from Verrucomicrobium spinosum DSM 4136 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 (has NQD)7396463_28_209 single domain, from Dyadobacter fermentans DSM 18053 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD)2761156_23_206 single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 (has NQD)560752_63_281 single domain, from Pirellula sp. 1 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD)11268538_332_511 with other domain, from Isosphaera pallida IS1B, ATCC 43644 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 (has NQD)6250794_21_205 with redox domain, from Chthoniobacter flavus Ellin428 10267460_32_215: single domain, from Spirosoma linguale DSM 74 (has NQD)10267460_32_215 single domain, from Spirosoma linguale DSM 74 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory