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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4592216_152_332: single domain, from Planctomyces maris DSM 8797 (has NEQ) 6253284_153_334: single domain, from Chthoniobacter flavus Ellin428 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 4592216_152_332 has N62 EQ 6253284_153_334 has N64 EQ 4592216_152_332 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 4592216_152_332 has N E72 Q 6253284_153_334 has N E74 Q 4592216_152_332 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 4592216_152_332 has NE Q74 6253284_153_334 has NE Q76 4592216_152_332 and 1 similar proteins have Q aligning to 166Q 4592216_152_332: single domain, from Planctomyces maris DSM 8797 4592216_152_3324592216_152_332: single domain, from Planctomyces maris DSM 8797 6253284_153_334: single domain, from Chthoniobacter flavus Ellin428 6253284_153_3346253284_153_334: single domain, from Chthoniobacter flavus Ellin428 4592216_152_332: single domain, from Planctomyces maris DSM 8797 (has NEQ)4592216_152_332 single domain, from Planctomyces maris DSM 8797 6253284_153_334: single domain, from Chthoniobacter flavus Ellin428 (has NEQ)6253284_153_334 single domain, from Chthoniobacter flavus Ellin428 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory