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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2220515_8_228: single domain, from Solibacter usitatus Ellin6076 (has GQD) 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 2220515_8_228 has G66 QD 11141775_41_262 has N67 QD 2220515_8_228 has G66 aligning to 134G 11141775_41_262 has N67 aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2220515_8_228 has G Q104 D 11141775_41_262 has N Q88 D 2220515_8_228 and 1 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 2220515_8_228 has GQ D106 11141775_41_262 has NQ D90 2220515_8_228 and 1 similar proteins have D aligning to 166D 2220515_8_228: single domain, from Solibacter usitatus Ellin6076 2220515_8_2282220515_8_228: single domain, from Solibacter usitatus Ellin6076 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 11141775_41_26211141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 2220515_8_228: single domain, from Solibacter usitatus Ellin6076 (has GQD)2220515_8_228 single domain, from Solibacter usitatus Ellin6076 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 (has NQD)11141775_41_262 single domain, from Runella slithyformis LSU4, DSM 19594 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory