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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.871 2220515_8_228: single domain, from Solibacter usitatus Ellin6076 11141775_41_262: single domain, from Runella slithyformis LSU4, DSM 19594 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Solibacter usitatus Ellin6076 2220515_8_228 single domain, from Solibacter usitatus Ellin6076 2220515_8_228 at #155: G1 2220515_8_228 at #155: G1 G 2220515_8_228 at #156: Y2 2220515_8_228 at #156: Y2 Y 2220515_8_228 at #157: V3 2220515_8_228 at #157: V3 V 2220515_8_228 at #158: S4 2220515_8_228 at #158: S4 S 2220515_8_228 at #159: L5 2220515_8_228 at #159: L5 L 2220515_8_228 at #160: F6 2220515_8_228 at #160: F6 F 2220515_8_228 at #162: D7 2220515_8_228 at #162: D7 D 2220515_8_228 at #164: G8 2220515_8_228 at #164: G8 G 2220515_8_228 at #165: V9 2220515_8_228 at #165: V9 V 2220515_8_228 at #168: S10 2220515_8_228 at #168: S10 S 2220515_8_228 at #169: L11 2220515_8_228 at #169: L11 L 2220515_8_228 at #171: K12 2220515_8_228 at #171: K12 K 2220515_8_228 at #172: G13 2220515_8_228 at #172: G13 G 2220515_8_228 at #180: W14 2220515_8_228 at #180: W14 W 2220515_8_228 at #181: D15 2220515_8_228 at #181: D15 D 2220515_8_228 at #185: G16 2220515_8_228 at #185: G16 G 2220515_8_228 at #186: N17 2220515_8_228 at #186: N17 N 2220515_8_228 at #187 2220515_8_228 at #187 - 2220515_8_228 at #188 2220515_8_228 at #188 - 2220515_8_228 at #189 2220515_8_228 at #189 - 2220515_8_228 at #190 2220515_8_228 at #190 - 2220515_8_228 at #191 2220515_8_228 at #191 - 2220515_8_228 at #195: P18 2220515_8_228 at #195: P18 P 2220515_8_228 at #196: K19 2220515_8_228 at #196: K19 K 2220515_8_228 at #197: F20 2220515_8_228 at #197: F20 F 2220515_8_228 at #198: W21 2220515_8_228 at #198: W21 W 2220515_8_228 at #235: R22 2220515_8_228 at #235: R22 R 2220515_8_228 at #236: V23 2220515_8_228 at #236: V23 V 2220515_8_228 at #237: E24 2220515_8_228 at #237: E24 E 2220515_8_228 at #238: G25 2220515_8_228 at #238: G25 G 2220515_8_228 at #240: G26 2220515_8_228 at #240: G26 G 2220515_8_228 at #268: A27 2220515_8_228 at #268: A27 A 2220515_8_228 at #269: I28 2220515_8_228 at #269: I28 I 2220515_8_228 at #270: V29 2220515_8_228 at #270: V29 V 2220515_8_228 at #294: Q34 2220515_8_228 at #294: Q34 Q 2220515_8_228 at #295: Q35 2220515_8_228 at #295: Q35 Q 2220515_8_228 at #296: N36 2220515_8_228 at #296: N36 N 2220515_8_228 at #297: P37 2220515_8_228 at #297: P37 P 2220515_8_228 at #298: S38 2220515_8_228 at #298: S38 S 2220515_8_228 at #299: G39 2220515_8_228 at #299: G39 G 2220515_8_228 at #300: N40 2220515_8_228 at #300: N40 N 2220515_8_228 at #301: S41 2220515_8_228 at #301: S41 S 2220515_8_228 at #303: Y42 2220515_8_228 at #303: Y42 Y 2220515_8_228 at #304: L43 2220515_8_228 at #304: L43 L 2220515_8_228 at #305: V44 2220515_8_228 at #305: V44 V 2220515_8_228 at #306: Y45 2220515_8_228 at #306: Y45 Y 2220515_8_228 at #312: R46 2220515_8_228 at #312: R46 R 2220515_8_228 at #318: D47 2220515_8_228 at #318: D47 D 2220515_8_228 at #321: V49 2220515_8_228 at #321: V49 V 2220515_8_228 at #322: A50 2220515_8_228 at #322: A50 A 2220515_8_228 at #324: K51 2220515_8_228 at #324: K51 K 2220515_8_228 at #326: D52 2220515_8_228 at #326: D52 D 2220515_8_228 at #327: F53 2220515_8_228 at #327: F53 F 2220515_8_228 at #328: T54 2220515_8_228 at #328: T54 T 2220515_8_228 at #329: L55 2220515_8_228 at #329: L55 L 2220515_8_228 at #330: K56 2220515_8_228 at #330: K56 K 2220515_8_228 at #331: F57 2220515_8_228 at #331: F57 F 2220515_8_228 at #332: E58 2220515_8_228 at #332: E58 E 2220515_8_228 at #333: I59 2220515_8_228 at #333: I59 I 2220515_8_228 at #334: K60 2220515_8_228 at #334: K60 K 2220515_8_228 at #335: V61 2220515_8_228 at #335: V61 V 2220515_8_228 at #351: E62 2220515_8_228 at #351: E62 E 2220515_8_228 at #352: G63 2220515_8_228 at #352: G63 G 2220515_8_228 at #354: S64 2220515_8_228 at #354: S64 S 2220515_8_228 at #355: G65 2220515_8_228 at #355: G65 G 2220515_8_228 at #385: G66 2220515_8_228 at #385: G66 G 2220515_8_228 at #386: S67 2220515_8_228 at #386: S67 S 2220515_8_228 at #387: G68 2220515_8_228 at #387: G68 G 2220515_8_228 at #388: F69 2220515_8_228 at #388: F69 F 2220515_8_228 at #389: Q70 2220515_8_228 at #389: Q70 Q 2220515_8_228 at #390: Y71 2220515_8_228 at #390: Y71 Y 2220515_8_228 at #391: R72 2220515_8_228 at #391: R72 R 2220515_8_228 at #392: S73 2220515_8_228 at #392: S73 S 2220515_8_228 at #393: K74 2220515_8_228 at #393: K74 K 2220515_8_228 at #423: P93 2220515_8_228 at #423: P93 P 2220515_8_228 at #424: V94 2220515_8_228 at #424: V94 V 2220515_8_228 at #425: N95 2220515_8_228 at #425: N95 N 2220515_8_228 at #426: L96 2220515_8_228 at #426: L96 L 2220515_8_228 at #430: N97 2220515_8_228 at #430: N97 N 2220515_8_228 at #431: W98 2220515_8_228 at #431: W98 W 2220515_8_228 at #432: M99 2220515_8_228 at #432: M99 M 2220515_8_228 at #433: M100 2220515_8_228 at #433: M100 M 2220515_8_228 at #434: T101 2220515_8_228 at #434: T101 T 2220515_8_228 at #435: G102 2220515_8_228 at #435: G102 G 2220515_8_228 at #436: P103 2220515_8_228 at #436: P103 P 2220515_8_228 at #438: Q104 2220515_8_228 at #438: Q104 Q 2220515_8_228 at #439: A105 2220515_8_228 at #439: A105 A 2220515_8_228 at #440: D106 2220515_8_228 at #440: D106 D 2220515_8_228 at #441: F107 2220515_8_228 at #441: F107 F 2220515_8_228 at #442: W108 2220515_8_228 at #442: W108 W 2220515_8_228 at #443: P109 2220515_8_228 at #443: P109 P 2220515_8_228 at #450: S110 2220515_8_228 at #450: S110 S 2220515_8_228 at #451: A111 2220515_8_228 at #451: A111 A 2220515_8_228 at #452 2220515_8_228 at #452 - 2220515_8_228 at #453 2220515_8_228 at #453 - 2220515_8_228 at #475 2220515_8_228 at #475 - 2220515_8_228 at #476 2220515_8_228 at #476 - 2220515_8_228 at #477 2220515_8_228 at #477 - 2220515_8_228 at #478: P112 2220515_8_228 at #478: P112 P 2220515_8_228 at #479: Y113 2220515_8_228 at #479: Y113 Y 2220515_8_228 at #480: W114 2220515_8_228 at #480: W114 W 2220515_8_228 at #481: T115 2220515_8_228 at #481: T115 T 2220515_8_228 at #482: G116 2220515_8_228 at #482: G116 G 2220515_8_228 at #483: Q117 2220515_8_228 at #483: Q117 Q 2220515_8_228 at #484: F118 2220515_8_228 at #484: F118 F 2220515_8_228 at #485: Y119 2220515_8_228 at #485: Y119 Y 2220515_8_228 at #486: S120 2220515_8_228 at #486: S120 S 2220515_8_228 at #487: E121 2220515_8_228 at #487: E121 E 2220515_8_228 at #530: I149 2220515_8_228 at #530: I149 I 2220515_8_228 at #532 2220515_8_228 at #532 - 2220515_8_228 at #533: G150 2220515_8_228 at #533: G150 G 2220515_8_228 at #534: D151 2220515_8_228 at #534: D151 D 2220515_8_228 at #535: R152 2220515_8_228 at #535: R152 R 2220515_8_228 at #544: D153 2220515_8_228 at #544: D153 D 2220515_8_228 at #545: A154 2220515_8_228 at #545: A154 A 2220515_8_228 at #548: L155 2220515_8_228 at #548: L155 L 2220515_8_228 at #549: G156 2220515_8_228 at #549: G156 G 2220515_8_228 at #550: K157 2220515_8_228 at #550: K157 K 2220515_8_228 at #551: L158 2220515_8_228 at #551: L158 L 2220515_8_228 at #552: V159 2220515_8_228 at #552: V159 V 2220515_8_228 at #553: R160 2220515_8_228 at #553: R160 R 2220515_8_228 at #554: M161 2220515_8_228 at #554: M161 M 2220515_8_228 at #555: N162 2220515_8_228 at #555: N162 N 2220515_8_228 at #556: D163 2220515_8_228 at #556: D163 D 2220515_8_228 at #557: W164 2220515_8_228 at #557: W164 W 2220515_8_228 at #558: N165 2220515_8_228 at #558: N165 N 2220515_8_228 at #559: E166 2220515_8_228 at #559: E166 E 2220515_8_228 at #560: Y167 2220515_8_228 at #560: Y167 Y 2220515_8_228 at #561: T168 2220515_8_228 at #561: T168 T 2220515_8_228 at #562: V169 2220515_8_228 at #562: V169 V 2220515_8_228 at #565: I170 2220515_8_228 at #565: I170 I 2220515_8_228 at #566: A171 2220515_8_228 at #566: A171 A 2220515_8_228 at #568: R172 2220515_8_228 at #568: R172 R 2220515_8_228 at #570: G173 2220515_8_228 at #570: G173 G 2220515_8_228 at #571: G174 2220515_8_228 at #571: G174 G 2220515_8_228 at #572: T175 2220515_8_228 at #572: T175 T 2220515_8_228 at #588: L176 2220515_8_228 at #588: L176 L 2220515_8_228 at #589: M177 2220515_8_228 at #589: M177 M 2220515_8_228 at #592: H178 2220515_8_228 at #592: H178 H 2220515_8_228 at #594: I179 2220515_8_228 at #594: I179 I 2220515_8_228 at #595: L180 2220515_8_228 at #595: L180 L 2220515_8_228 at #596: N181 2220515_8_228 at #596: N181 N 2220515_8_228 at #598: G182 2220515_8_228 at #598: G182 G 2220515_8_228 at #599: Q183 2220515_8_228 at #599: Q183 Q 2220515_8_228 at #600: L184 2220515_8_228 at #600: L184 L 2220515_8_228 at #601: M185 2220515_8_228 at #601: M185 M 2220515_8_228 at #602: A186 2220515_8_228 at #602: A186 A 2220515_8_228 at #603: V187 2220515_8_228 at #603: V187 V 2220515_8_228 at #604: M188 2220515_8_228 at #604: M188 M 2220515_8_228 at #605: V189 2220515_8_228 at #605: V189 V 2220515_8_228 at #606: D190 2220515_8_228 at #606: D190 D 2220515_8_228 at #607: D191 2220515_8_228 at #607: D191 D 2220515_8_228 at #608: D192 2220515_8_228 at #608: D192 D 2220515_8_228 at #609: P193 2220515_8_228 at #609: P193 P 2220515_8_228 at #610: E194 2220515_8_228 at #610: E194 E 2220515_8_228 at #611: S195 2220515_8_228 at #611: S195 S 2220515_8_228 at #612: S196 2220515_8_228 at #612: S196 S 2220515_8_228 at #613: N197 2220515_8_228 at #613: N197 N 2220515_8_228 at #614: N198 2220515_8_228 at #614: N198 N 2220515_8_228 at #615 2220515_8_228 at #615 - 2220515_8_228 at #616 2220515_8_228 at #616 - 2220515_8_228 at #640 2220515_8_228 at #640 - 2220515_8_228 at #641 2220515_8_228 at #641 - 2220515_8_228 at #642 2220515_8_228 at #642 - 2220515_8_228 at #643: Q199 2220515_8_228 at #643: Q199 Q 2220515_8_228 at #644: P200 2220515_8_228 at #644: P200 P 2220515_8_228 at #645: G201 2220515_8_228 at #645: G201 G 2220515_8_228 at #646: L202 2220515_8_228 at #646: L202 L 2220515_8_228 at #647: F203 2220515_8_228 at #647: F203 F 2220515_8_228 at #648: G204 2220515_8_228 at #648: G204 G 2220515_8_228 at #649: I205 2220515_8_228 at #649: I205 I 2220515_8_228 at #650: E206 2220515_8_228 at #650: E206 E 2220515_8_228 at #653: E208 2220515_8_228 at #653: E208 E 2220515_8_228 at #654: A209 2220515_8_228 at #654: A209 A 2220515_8_228 at #655: T210 2220515_8_228 at #655: T210 T 2220515_8_228 at #668: T211 2220515_8_228 at #668: T211 T 2220515_8_228 at #689: K212 2220515_8_228 at #689: K212 K 2220515_8_228 at #690: V213 2220515_8_228 at #690: V213 V 2220515_8_228 at #691: S214 2220515_8_228 at #691: S214 S 2220515_8_228 at #694: V215 2220515_8_228 at #694: V215 V 2220515_8_228 at #695: R216 2220515_8_228 at #695: R216 R 2220515_8_228 at #696: N217 2220515_8_228 at #696: N217 N 2220515_8_228 at #697: I218 2220515_8_228 at #697: I218 I 2220515_8_228 at #698: W219 2220515_8_228 at #698: W219 W 2220515_8_228 at #699: V220 2220515_8_228 at #699: V220 V 2220515_8_228 at #700: K221 2220515_8_228 at #700: K221 K single domain, from Runella slithyformis LSU4, DSM 19594 11141775_41_262 single domain, from Runella slithyformis LSU4, DSM 19594 11141775_41_262 at #155: G1 11141775_41_262 at #155: G1 G 11141775_41_262 at #156: F2 11141775_41_262 at #156: F2 F 11141775_41_262 at #157: V3 11141775_41_262 at #157: V3 V 11141775_41_262 at #158: Q4 11141775_41_262 at #158: Q4 Q 11141775_41_262 at #159: I5 11141775_41_262 at #159: I5 I 11141775_41_262 at #160: F6 11141775_41_262 at #160: F6 F 11141775_41_262 at #162: D7 11141775_41_262 at #162: D7 D 11141775_41_262 at #164: G8 11141775_41_262 at #164: G8 G 11141775_41_262 at #165: K9 11141775_41_262 at #165: K9 K 11141775_41_262 at #168: T10 11141775_41_262 at #168: T10 T 11141775_41_262 at #169: L11 11141775_41_262 at #169: L11 L 11141775_41_262 at #171: N12 11141775_41_262 at #171: N12 N 11141775_41_262 at #172: G13 11141775_41_262 at #172: G13 G 11141775_41_262 at #180: W14 11141775_41_262 at #180: W14 W 11141775_41_262 at #181: D15 11141775_41_262 at #181: D15 D 11141775_41_262 at #185: G16 11141775_41_262 at #185: G16 G 11141775_41_262 at #186: D17 11141775_41_262 at #186: D17 D 11141775_41_262 at #187: P18 11141775_41_262 at #187: P18 P 11141775_41_262 at #188: T19 11141775_41_262 at #188: T19 T 11141775_41_262 at #189: Y20 11141775_41_262 at #189: Y20 Y 11141775_41_262 at #190: W21 11141775_41_262 at #190: W21 W 11141775_41_262 at #191: R22 11141775_41_262 at #191: R22 R 11141775_41_262 at #195: A23 11141775_41_262 at #195: A23 A 11141775_41_262 at #196 11141775_41_262 at #196 - 11141775_41_262 at #197 11141775_41_262 at #197 - 11141775_41_262 at #198 11141775_41_262 at #198 - 11141775_41_262 at #235 11141775_41_262 at #235 - 11141775_41_262 at #236 11141775_41_262 at #236 - 11141775_41_262 at #237: E24 11141775_41_262 at #237: E24 E 11141775_41_262 at #238: N25 11141775_41_262 at #238: N25 N 11141775_41_262 at #240: G26 11141775_41_262 at #240: G26 G 11141775_41_262 at #268: N27 11141775_41_262 at #268: N27 N 11141775_41_262 at #269: L28 11141775_41_262 at #269: L28 L 11141775_41_262 at #270: V29 11141775_41_262 at #270: V29 V 11141775_41_262 at #294: T35 11141775_41_262 at #294: T35 T 11141775_41_262 at #295: T36 11141775_41_262 at #295: T36 T 11141775_41_262 at #296: L37 11141775_41_262 at #296: L37 L 11141775_41_262 at #297: L38 11141775_41_262 at #297: L38 L 11141775_41_262 at #298: K39 11141775_41_262 at #298: K39 K 11141775_41_262 at #299: T40 11141775_41_262 at #299: T40 T 11141775_41_262 at #300: N41 11141775_41_262 at #300: N41 N 11141775_41_262 at #301: S42 11141775_41_262 at #301: S42 S 11141775_41_262 at #303: F43 11141775_41_262 at #303: F43 F 11141775_41_262 at #304: I44 11141775_41_262 at #304: I44 I 11141775_41_262 at #305: I45 11141775_41_262 at #305: I45 I 11141775_41_262 at #306: W46 11141775_41_262 at #306: W46 W 11141775_41_262 at #312: K47 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Q215 Q 11141775_41_262 at #694: Y216 11141775_41_262 at #694: Y216 Y 11141775_41_262 at #695: R217 11141775_41_262 at #695: R217 R 11141775_41_262 at #696: N218 11141775_41_262 at #696: N218 N 11141775_41_262 at #697: L219 11141775_41_262 at #697: L219 L 11141775_41_262 at #698: R220 11141775_41_262 at #698: R220 R 11141775_41_262 at #699: L221 11141775_41_262 at #699: L221 L 11141775_41_262 at #700: K222 11141775_41_262 at #700: K222 K download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory