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Zoomed into a clade of 6 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 (has NQD) 556853_51_260: single domain, from Pirellula sp. 1 (has NQE) 6004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 (has NQE) 6254877_31_231: single domain, from Chthoniobacter flavus Ellin428 (has NQE) 6253153_22_242: single domain, from Chthoniobacter flavus Ellin428 (has NQD) 559512_79_278: single domain, from Pirellula sp. 1 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 2760957_28_228 has N66 QD 556853_51_260 has N66 QE 6004807_27_244 has N66 QE 6254877_31_231 has N64 QE 6253153_22_242 has N72 QD 559512_79_278 has N64 QD 2760957_28_228 and 5 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2760957_28_228 has N Q85 D 556853_51_260 has N Q91 E 6004807_27_244 has N Q87 E 6254877_31_231 has N Q83 E 6253153_22_242 has N Q93 D 559512_79_278 has N Q85 D 2760957_28_228 and 5 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 2760957_28_228 has NQ D87 556853_51_260 has NQ E93 6004807_27_244 has NQ E89 6254877_31_231 has NQ E85 6253153_22_242 has NQ D95 559512_79_278 has NQ D87 2760957_28_228 has D87 aligning to 166D 556853_51_260 and 2 similar proteins have E aligning to 166E 6253153_22_242 has D95 aligning to 166D 559512_79_278 has D87 aligning to 166D 0.577 2760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 2760957_28_2282760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 0.920 0.941 0.518 556853_51_260: single domain, from Pirellula sp. 1 556853_51_260556853_51_260: single domain, from Pirellula sp. 1 6004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 6004807_27_2446004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 6254877_31_231: single domain, from Chthoniobacter flavus Ellin428 6254877_31_2316254877_31_231: single domain, from Chthoniobacter flavus Ellin428 6253153_22_242: single domain, from Chthoniobacter flavus Ellin428 6253153_22_2426253153_22_242: single domain, from Chthoniobacter flavus Ellin428 559512_79_278: single domain, from Pirellula sp. 1 559512_79_278559512_79_278: single domain, from Pirellula sp. 1 2760957_28_228: with redox domain, from Blastopirellula marina DSM 3645 (has NQD)2760957_28_228 with redox domain, from Blastopirellula marina DSM 3645 556853_51_260: single domain, from Pirellula sp. 1 (has NQE)556853_51_260 single domain, from Pirellula sp. 1 6004807_27_244: single domain, from Verrucomicrobium spinosum DSM 4136 (has NQE)6004807_27_244 single domain, from Verrucomicrobium spinosum DSM 4136 6254877_31_231: single domain, from Chthoniobacter flavus Ellin428 (has NQE)6254877_31_231 single domain, from Chthoniobacter flavus Ellin428 6253153_22_242: single domain, from Chthoniobacter flavus Ellin428 (has NQD)6253153_22_242 single domain, from Chthoniobacter flavus Ellin428 559512_79_278: single domain, from Pirellula sp. 1 (has NQD)559512_79_278 single domain, from Pirellula sp. 1 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory