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Zoomed into a clade of 4 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD) 554416_28_225: with redox domain, from Pirellula sp. 1 (has NQD) 4611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 (has NQD) 11296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 11293204_36_238 has N69 QD 554416_28_225 has N65 QD 4611874_988_1186 has N65 QD 11296383_24_224 has N67 QD 11293204_36_238 and 3 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11293204_36_238 has N Q88 D 554416_28_225 has N Q86 D 4611874_988_1186 has N Q86 D 11296383_24_224 has N Q89 D 11293204_36_238 and 3 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11293204_36_238 has NQ D90 554416_28_225 has NQ D88 4611874_988_1186 has NQ D88 11296383_24_224 has NQ D91 11293204_36_238 and 3 similar proteins have D aligning to 166D 11293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 11293204_36_23811293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 0.887 0.870 554416_28_225: with redox domain, from Pirellula sp. 1 554416_28_225554416_28_225: with redox domain, from Pirellula sp. 1 4611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 4611874_988_11864611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 11296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 11296383_24_22411296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 11293204_36_238: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD)11293204_36_238 with redox domain, from Planctomyces brasiliensis DSM 5305 554416_28_225: with redox domain, from Pirellula sp. 1 (has NQD)554416_28_225 with redox domain, from Pirellula sp. 1 4611874_988_1186: with redox domain, from Lentisphaera araneosa HTCC2155 (has NQD)4611874_988_1186 with redox domain, from Lentisphaera araneosa HTCC2155 11296383_24_224: with redox domain, from Planctomyces brasiliensis DSM 5305 (has NQD)11296383_24_224 with redox domain, from Planctomyces brasiliensis DSM 5305 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory