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Zoomed into a clade of 12 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 (has NQD) 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 (has NQD) 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 (has NQD) 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD) 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 (has NQD) 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has NQD) 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 (has NQD) 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD) 560752_63_281: single domain, from Pirellula sp. 1 (has NQD) 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD) 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 (has NQD) 10267460_32_215: single domain, from Spirosoma linguale DSM 74 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 11227501_33_203 has N65 QD 2761067_1173_1341 has N62 QD 4911453_35_208 has N56 QD 11272043_27_202 has N65 QD 6378172_468_664 has N71 QD 6003860_25_205 has N66 QD 7396463_28_209 has N67 QD 2761156_23_206 has N65 QD 560752_63_281 has N65 QD 11268538_332_511 has N66 QD 6250794_21_205 has N70 QD 10267460_32_215 has N73 QD 11227501_33_203 and 11 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11227501_33_203 has N Q83 D 2761067_1173_1341 has N Q81 D 4911453_35_208 has N Q81 D 11272043_27_202 has N Q84 D 6378172_468_664 has N Q94 D 6003860_25_205 has N Q87 D 7396463_28_209 has N Q88 D 2761156_23_206 has N Q85 D 560752_63_281 has N Q90 D 11268538_332_511 has N Q86 D 6250794_21_205 has N Q90 D 10267460_32_215 has N Q91 D 11227501_33_203 and 11 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11227501_33_203 has NQ D85 2761067_1173_1341 has NQ D83 4911453_35_208 has NQ D83 11272043_27_202 has NQ D86 6378172_468_664 has NQ D96 6003860_25_205 has NQ D89 7396463_28_209 has NQ D90 2761156_23_206 has NQ D87 560752_63_281 has NQ D92 11268538_332_511 has NQ D88 6250794_21_205 has NQ D92 10267460_32_215 has NQ D93 11227501_33_203 and 11 similar proteins have D aligning to 166D 0.809 0.707 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 11227501_33_20311227501_33_203: single domain, from Cyclobacterium marinum DSM 745 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 2761067_1173_13412761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 0.866 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 4911453_35_2084911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 11272043_27_20211272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 0.811 0.719 0.489 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 6378172_468_6646378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 0.861 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 6003860_25_2056003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 7396463_28_2097396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 0.910 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 2761156_23_2062761156_23_206: single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 560752_63_281560752_63_281: single domain, from Pirellula sp. 1 0.551 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 11268538_332_51111268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 0.513 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 6250794_21_2056250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 10267460_32_215: single domain, from Spirosoma linguale DSM 74 10267460_32_21510267460_32_215: single domain, from Spirosoma linguale DSM 74 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 (has NQD)11227501_33_203 single domain, from Cyclobacterium marinum DSM 745 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 (has NQD)2761067_1173_1341 with redox domain, from Blastopirellula marina DSM 3645 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 (has NQD)4911453_35_208 single domain, from Gemmata obscuriglobus UQM 2246 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD)11272043_27_202 single domain, from Isosphaera pallida IS1B, ATCC 43644 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 (has NQD)6378172_468_664 with other domain, from Bacteroides cellulosilyticus DSM 14838 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has NQD)6003860_25_205 with redox domain, from Verrucomicrobium spinosum DSM 4136 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 (has NQD)7396463_28_209 single domain, from Dyadobacter fermentans DSM 18053 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD)2761156_23_206 single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 (has NQD)560752_63_281 single domain, from Pirellula sp. 1 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD)11268538_332_511 with other domain, from Isosphaera pallida IS1B, ATCC 43644 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 (has NQD)6250794_21_205 with redox domain, from Chthoniobacter flavus Ellin428 10267460_32_215: single domain, from Spirosoma linguale DSM 74 (has NQD)10267460_32_215 single domain, from Spirosoma linguale DSM 74 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory