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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 (has NQD) 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 11227501_33_203 has N65 QD 2761067_1173_1341 has N62 QD 11227501_33_203 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11227501_33_203 has N Q83 D 2761067_1173_1341 has N Q81 D 11227501_33_203 and 1 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11227501_33_203 has NQ D85 2761067_1173_1341 has NQ D83 11227501_33_203 and 1 similar proteins have D aligning to 166D 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 11227501_33_20311227501_33_203: single domain, from Cyclobacterium marinum DSM 745 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 2761067_1173_13412761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 11227501_33_203: single domain, from Cyclobacterium marinum DSM 745 (has NQD)11227501_33_203 single domain, from Cyclobacterium marinum DSM 745 2761067_1173_1341: with redox domain, from Blastopirellula marina DSM 3645 (has NQD)2761067_1173_1341 with redox domain, from Blastopirellula marina DSM 3645 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory