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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 (has NQD) 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 4911453_35_208 has N56 QD 11272043_27_202 has N65 QD 4911453_35_208 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 4911453_35_208 has N Q81 D 11272043_27_202 has N Q84 D 4911453_35_208 and 1 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 4911453_35_208 has NQ D83 11272043_27_202 has NQ D86 4911453_35_208 and 1 similar proteins have D aligning to 166D 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 4911453_35_2084911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 11272043_27_20211272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 4911453_35_208: single domain, from Gemmata obscuriglobus UQM 2246 (has NQD)4911453_35_208 single domain, from Gemmata obscuriglobus UQM 2246 11272043_27_202: single domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD)11272043_27_202 single domain, from Isosphaera pallida IS1B, ATCC 43644 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory