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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 (has NQD) 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has NQD) 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 (has NQD) 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD) 560752_63_281: single domain, from Pirellula sp. 1 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 6378172_468_664 has N71 QD 6003860_25_205 has N66 QD 7396463_28_209 has N67 QD 2761156_23_206 has N65 QD 560752_63_281 has N65 QD 6378172_468_664 and 4 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 6378172_468_664 has N Q94 D 6003860_25_205 has N Q87 D 7396463_28_209 has N Q88 D 2761156_23_206 has N Q85 D 560752_63_281 has N Q90 D 6378172_468_664 and 4 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 6378172_468_664 has NQ D96 6003860_25_205 has NQ D89 7396463_28_209 has NQ D90 2761156_23_206 has NQ D87 560752_63_281 has NQ D92 6378172_468_664 and 4 similar proteins have D aligning to 166D 0.489 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 6378172_468_6646378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 0.861 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 6003860_25_2056003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 7396463_28_2097396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 0.910 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 2761156_23_2062761156_23_206: single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 560752_63_281560752_63_281: single domain, from Pirellula sp. 1 6378172_468_664: with other domain, from Bacteroides cellulosilyticus DSM 14838 (has NQD)6378172_468_664 with other domain, from Bacteroides cellulosilyticus DSM 14838 6003860_25_205: with redox domain, from Verrucomicrobium spinosum DSM 4136 (has NQD)6003860_25_205 with redox domain, from Verrucomicrobium spinosum DSM 4136 7396463_28_209: single domain, from Dyadobacter fermentans DSM 18053 (has NQD)7396463_28_209 single domain, from Dyadobacter fermentans DSM 18053 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD)2761156_23_206 single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 (has NQD)560752_63_281 single domain, from Pirellula sp. 1 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory