Sites on a Tree

 

Download tree, alignment (240 x 716), positions, or descriptions, or see permanent link to this page, or start over.

Upload descriptions:
The table should be tab-delimited with the sequence identifier in the 1st column and the description in the 2nd column. Optionally, add fields named color and URL.

Select positions to show: in

Or see functional positions, see filtered positions, or see all positions.

Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

Find sequence pattern:

Highlight proteins:

2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD) 560752_63_281: single domain, from Pirellula sp. 1 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 2761156_23_206 has N65 QD 560752_63_281 has N65 QD 2761156_23_206 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2761156_23_206 has N Q85 D 560752_63_281 has N Q90 D 2761156_23_206 and 1 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 2761156_23_206 has NQ D87 560752_63_281 has NQ D92 2761156_23_206 and 1 similar proteins have D aligning to 166D 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 2761156_23_2062761156_23_206: single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 560752_63_281560752_63_281: single domain, from Pirellula sp. 1 2761156_23_206: single domain, from Blastopirellula marina DSM 3645 (has NQD)2761156_23_206 single domain, from Blastopirellula marina DSM 3645 560752_63_281: single domain, from Pirellula sp. 1 (has NQD)560752_63_281 single domain, from Pirellula sp. 1 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory