Sites on a Tree

 

Download tree, alignment (240 x 716), positions, or descriptions, or see permanent link to this page, or start over.

Upload descriptions:
The table should be tab-delimited with the sequence identifier in the 1st column and the description in the 2nd column. Optionally, add fields named color and URL.

Select positions to show: in

Or see functional positions, see filtered positions, or see all positions.

Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

Find sequence pattern:

Highlight proteins:

11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD) 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 (has NQD) 10267460_32_215: single domain, from Spirosoma linguale DSM 74 (has NQD) BT2157 has N at position 134 (alignment position 385)N134 11268538_332_511 has N66 QD 6250794_21_205 has N70 QD 10267460_32_215 has N73 QD 11268538_332_511 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11268538_332_511 has N Q86 D 6250794_21_205 has N Q90 D 10267460_32_215 has N Q91 D 11268538_332_511 and 2 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11268538_332_511 has NQ D88 6250794_21_205 has NQ D92 10267460_32_215 has NQ D93 11268538_332_511 and 2 similar proteins have D aligning to 166D 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 11268538_332_51111268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 0.513 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 6250794_21_2056250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 10267460_32_215: single domain, from Spirosoma linguale DSM 74 10267460_32_21510267460_32_215: single domain, from Spirosoma linguale DSM 74 11268538_332_511: with other domain, from Isosphaera pallida IS1B, ATCC 43644 (has NQD)11268538_332_511 with other domain, from Isosphaera pallida IS1B, ATCC 43644 6250794_21_205: with redox domain, from Chthoniobacter flavus Ellin428 (has NQD)6250794_21_205 with redox domain, from Chthoniobacter flavus Ellin428 10267460_32_215: single domain, from Spirosoma linguale DSM 74 (has NQD)10267460_32_215 single domain, from Spirosoma linguale DSM 74 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory