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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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2221983_152_318: single domain, from Solibacter usitatus Ellin6076 (has QQQ) 4909784_48_228: single domain, from Gemmata obscuriglobus UQM 2246 (has HDS) BT2157 has N at position 134 (alignment position 385)N134 2221983_152_318 has Q45 QQ 4909784_48_228 has H63 DS 2221983_152_318 has Q45 aligning to 134Q 4909784_48_228 has H63 aligning to 134H BT2157 has E at position 164 (alignment position 438)E164 2221983_152_318 has Q Q69 Q 4909784_48_228 has H D75 S 2221983_152_318 has Q69 aligning to 164Q 4909784_48_228 has D75 aligning to 164D BT2157 has Q at position 166 (alignment position 440)Q166 2221983_152_318 has QQ Q71 4909784_48_228 has HD S77 2221983_152_318 has Q71 aligning to 166Q 4909784_48_228 has S77 aligning to 166S 2221983_152_318: single domain, from Solibacter usitatus Ellin6076 2221983_152_3182221983_152_318: single domain, from Solibacter usitatus Ellin6076 4909784_48_228: single domain, from Gemmata obscuriglobus UQM 2246 4909784_48_2284909784_48_228: single domain, from Gemmata obscuriglobus UQM 2246 2221983_152_318: single domain, from Solibacter usitatus Ellin6076 (has QQQ)2221983_152_318 single domain, from Solibacter usitatus Ellin6076 4909784_48_228: single domain, from Gemmata obscuriglobus UQM 2246 (has HDS)4909784_48_228 single domain, from Gemmata obscuriglobus UQM 2246 1 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory