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Zoomed into a clade of 6 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

6001914_31_230: single domain, from Verrucomicrobium spinosum DSM 4136 (has NQE) 4616165_23_217: single domain, from Lentisphaera araneosa HTCC2155 (has NQE) 554998_519_700: with redox domain, from Pirellula sp. 1 (has NQE) 4612229_39_228: single domain, from Lentisphaera araneosa HTCC2155 (has NQE) 10304809_24_215: single domain, from Pirellula staleyi DSM 6068 (has NQD) 10359243_331_522: with redox domain, from Coraliomargarita akajimensis DSM 45221 (has NQE) BT2157 has N at position 134 (alignment position 385)N134 6001914_31_230 has N63 QE 4616165_23_217 has N65 QE 554998_519_700 has N65 QE 4612229_39_228 has N66 QE 10304809_24_215 has N64 QD 10359243_331_522 has N64 QE 6001914_31_230 and 5 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 6001914_31_230 has N Q96 E 4616165_23_217 has N Q90 E 554998_519_700 has N Q85 E 4612229_39_228 has N Q86 E 10304809_24_215 has N Q90 D 10359243_331_522 has N Q86 E 6001914_31_230 and 5 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 6001914_31_230 has NQ E98 4616165_23_217 has NQ E92 554998_519_700 has NQ E87 4612229_39_228 has NQ E88 10304809_24_215 has NQ D92 10359243_331_522 has NQ E88 6001914_31_230 and 3 similar proteins have E aligning to 166E 10304809_24_215 has D92 aligning to 166D 10359243_331_522 has E88 aligning to 166E 0.462 0.701 6001914_31_230: single domain, from Verrucomicrobium spinosum DSM 4136 6001914_31_2306001914_31_230: single domain, from Verrucomicrobium spinosum DSM 4136 4616165_23_217: single domain, from Lentisphaera araneosa HTCC2155 4616165_23_2174616165_23_217: single domain, from Lentisphaera araneosa HTCC2155 0.896 554998_519_700: with redox domain, from Pirellula sp. 1 554998_519_700554998_519_700: with redox domain, from Pirellula sp. 1 4612229_39_228: single domain, from Lentisphaera araneosa HTCC2155 4612229_39_2284612229_39_228: single domain, from Lentisphaera araneosa HTCC2155 0.412 10304809_24_215: single domain, from Pirellula staleyi DSM 6068 10304809_24_21510304809_24_215: single domain, from Pirellula staleyi DSM 6068 10359243_331_522: with redox domain, from Coraliomargarita akajimensis DSM 45221 10359243_331_52210359243_331_522: with redox domain, from Coraliomargarita akajimensis DSM 45221 6001914_31_230: single domain, from Verrucomicrobium spinosum DSM 4136 (has NQE)6001914_31_230 single domain, from Verrucomicrobium spinosum DSM 4136 4616165_23_217: single domain, from Lentisphaera araneosa HTCC2155 (has NQE)4616165_23_217 single domain, from Lentisphaera araneosa HTCC2155 554998_519_700: with redox domain, from Pirellula sp. 1 (has NQE)554998_519_700 with redox domain, from Pirellula sp. 1 4612229_39_228: single domain, from Lentisphaera araneosa HTCC2155 (has NQE)4612229_39_228 single domain, from Lentisphaera araneosa HTCC2155 10304809_24_215: single domain, from Pirellula staleyi DSM 6068 (has NQD)10304809_24_215 single domain, from Pirellula staleyi DSM 6068 10359243_331_522: with redox domain, from Coraliomargarita akajimensis DSM 45221 (has NQE)10359243_331_522 with redox domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory