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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

0.986 0.462 0.701 6001914_31_230: single domain, from Verrucomicrobium spinosum DSM 4136 4616165_23_217: single domain, from Lentisphaera araneosa HTCC2155 0.896 554998_519_700: with redox domain, from Pirellula sp. 1 4612229_39_228: single domain, from Lentisphaera araneosa HTCC2155 0.412 10304809_24_215: single domain, from Pirellula staleyi DSM 6068 10359243_331_522: with redox domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site single domain, from Verrucomicrobium spinosum DSM 4136 6001914_31_230 single domain, from Verrucomicrobium spinosum DSM 4136 single domain, from Lentisphaera araneosa HTCC2155 4616165_23_217 single domain, from Lentisphaera araneosa HTCC2155 with redox domain, from Pirellula sp. 1 554998_519_700 with redox domain, from Pirellula sp. 1 single domain, from Lentisphaera araneosa HTCC2155 4612229_39_228 single domain, from Lentisphaera araneosa HTCC2155 single domain, from Pirellula staleyi DSM 6068 10304809_24_215 single domain, from Pirellula staleyi DSM 6068 with redox domain, from Coraliomargarita akajimensis DSM 45221 10359243_331_522 with redox domain, from Coraliomargarita akajimensis DSM 45221 download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory