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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.412 10304809_24_215: single domain, from Pirellula staleyi DSM 6068 10359243_331_522: with redox domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Pirellula staleyi DSM 6068 10304809_24_215 single domain, from Pirellula staleyi DSM 6068 10304809_24_215 at #155: D1 10304809_24_215 at #155: D1 D 10304809_24_215 at #156: W2 10304809_24_215 at #156: W2 W 10304809_24_215 at #157: Q3 10304809_24_215 at #157: Q3 Q 10304809_24_215 at #158: V4 10304809_24_215 at #158: V4 V 10304809_24_215 at #159: L5 10304809_24_215 at #159: L5 L 10304809_24_215 at #160: F6 10304809_24_215 at #160: F6 F 10304809_24_215 at #162: D7 10304809_24_215 at #162: D7 D 10304809_24_215 at #164: G8 10304809_24_215 at #164: G8 G 10304809_24_215 at #165: T9 10304809_24_215 at #165: T9 T 10304809_24_215 at #168: S10 10304809_24_215 at #168: S10 S 10304809_24_215 at #169: L11 10304809_24_215 at #169: L11 L 10304809_24_215 at #171: Q12 10304809_24_215 at #171: Q12 Q 10304809_24_215 at #172: G13 10304809_24_215 at #172: G13 G 10304809_24_215 at #180: W14 10304809_24_215 at #180: W14 W 10304809_24_215 at #181: Q15 10304809_24_215 at #181: Q15 Q 10304809_24_215 at #185: P16 10304809_24_215 at #185: P16 P 10304809_24_215 at #186: S17 10304809_24_215 at #186: S17 S 10304809_24_215 at #187: N18 10304809_24_215 at #187: N18 N 10304809_24_215 at #188: D19 10304809_24_215 at #188: D19 D 10304809_24_215 at #189: N20 10304809_24_215 at #189: N20 N 10304809_24_215 at #190 10304809_24_215 at #190 - 10304809_24_215 at #191 10304809_24_215 at #191 - 10304809_24_215 at #195 10304809_24_215 at #195 - 10304809_24_215 at #196: M21 10304809_24_215 at #196: M21 M 10304809_24_215 at #197: Q22 10304809_24_215 at #197: Q22 Q 10304809_24_215 at #198: F23 10304809_24_215 at #198: F23 F 10304809_24_215 at #235: E24 10304809_24_215 at #235: E24 E 10304809_24_215 at #236: L25 10304809_24_215 at #236: L25 L 10304809_24_215 at #237: V26 10304809_24_215 at #237: V26 V 10304809_24_215 at #238: D27 10304809_24_215 at #238: D27 D 10304809_24_215 at #240: G28 10304809_24_215 at #240: G28 G 10304809_24_215 at #268: V29 10304809_24_215 at #268: V29 V 10304809_24_215 at #269: I30 10304809_24_215 at #269: I30 I 10304809_24_215 at #270: L31 10304809_24_215 at #270: L31 L 10304809_24_215 at #294: G32 10304809_24_215 at #294: G32 G 10304809_24_215 at #295: S33 10304809_24_215 at #295: S33 S 10304809_24_215 at #296: S34 10304809_24_215 at #296: S34 S 10304809_24_215 at #297: S35 10304809_24_215 at #297: S35 S 10304809_24_215 at #298: A36 10304809_24_215 at #298: A36 A 10304809_24_215 at #299: Q37 10304809_24_215 at #299: Q37 Q 10304809_24_215 at #300: T38 10304809_24_215 at #300: T38 T 10304809_24_215 at #301: H39 10304809_24_215 at #301: H39 H 10304809_24_215 at #303: F40 10304809_24_215 at #303: F40 F 10304809_24_215 at #304: L41 10304809_24_215 at #304: L41 L 10304809_24_215 at #305: V42 10304809_24_215 at #305: V42 V 10304809_24_215 at #306: T43 10304809_24_215 at #306: T43 T 10304809_24_215 at #312: S44 10304809_24_215 at #312: S44 S 10304809_24_215 at #318: S45 10304809_24_215 at #318: S45 S 10304809_24_215 at #321: K46 10304809_24_215 at #321: K46 K 10304809_24_215 at #322: Y47 10304809_24_215 at #322: Y47 Y 10304809_24_215 at #324: G48 10304809_24_215 at #324: G48 G 10304809_24_215 at #326: D49 10304809_24_215 at #326: D49 D 10304809_24_215 at #327: F50 10304809_24_215 at #327: F50 F 10304809_24_215 at #328: E51 10304809_24_215 at #328: E51 E 10304809_24_215 at #329: L52 10304809_24_215 at #329: L52 L 10304809_24_215 at #330: E53 10304809_24_215 at #330: E53 E 10304809_24_215 at #331: L54 10304809_24_215 at #331: L54 L 10304809_24_215 at #332: E55 10304809_24_215 at #332: E55 E 10304809_24_215 at #333: V56 10304809_24_215 at #333: V56 V 10304809_24_215 at #334: K57 10304809_24_215 at #334: K57 K 10304809_24_215 at #335: L58 10304809_24_215 at #335: L58 L 10304809_24_215 at #351: H59 10304809_24_215 at #351: H59 H 10304809_24_215 at #352: D60 10304809_24_215 at #352: D60 D 10304809_24_215 at #354: T61 10304809_24_215 at #354: T61 T 10304809_24_215 at #355: D62 10304809_24_215 at #355: D62 D 10304809_24_215 at #385: N64 10304809_24_215 at #385: N64 N 10304809_24_215 at #386: S65 10304809_24_215 at #386: S65 S 10304809_24_215 at #387: G66 10304809_24_215 at #387: G66 G 10304809_24_215 at #388: V67 10304809_24_215 at #388: V67 V 10304809_24_215 at #389: Q68 10304809_24_215 at #389: Q68 Q 10304809_24_215 at #390: I69 10304809_24_215 at #390: I69 I 10304809_24_215 at #391: R70 10304809_24_215 at #391: R70 R 10304809_24_215 at #392: T71 10304809_24_215 at #392: T71 T 10304809_24_215 at #393: S72 10304809_24_215 at #393: S72 S 10304809_24_215 at #423: K79 10304809_24_215 at #423: K79 K 10304809_24_215 at #424: G80 10304809_24_215 at #424: G80 G 10304809_24_215 at #425: D81 10304809_24_215 at #425: D81 D 10304809_24_215 at #426: S82 10304809_24_215 at #426: S82 S 10304809_24_215 at #430: R83 10304809_24_215 at #430: R83 R 10304809_24_215 at #431: A84 10304809_24_215 at #431: A84 A 10304809_24_215 at #432: V85 10304809_24_215 at #432: V85 V 10304809_24_215 at #433: I86 10304809_24_215 at #433: I86 I 10304809_24_215 at #434: H87 10304809_24_215 at #434: H87 H 10304809_24_215 at #435: G88 10304809_24_215 at #435: G88 G 10304809_24_215 at #436: P89 10304809_24_215 at #436: P89 P 10304809_24_215 at #438: Q90 10304809_24_215 at #438: Q90 Q 10304809_24_215 at #439: V91 10304809_24_215 at #439: V91 V 10304809_24_215 at #440: D92 10304809_24_215 at #440: D92 D 10304809_24_215 at #441: L93 10304809_24_215 at #441: L93 L 10304809_24_215 at #442: G94 10304809_24_215 at #442: G94 G 10304809_24_215 at #443: K95 10304809_24_215 at #443: K95 K 10304809_24_215 at #450: S96 10304809_24_215 at #450: S96 S 10304809_24_215 at #451: P97 10304809_24_215 at #451: P97 P 10304809_24_215 at #452: G98 10304809_24_215 at #452: G98 G 10304809_24_215 at #453 10304809_24_215 at #453 - 10304809_24_215 at #475 10304809_24_215 at #475 - 10304809_24_215 at #476 10304809_24_215 at #476 - 10304809_24_215 at #477 10304809_24_215 at #477 - 10304809_24_215 at #478 10304809_24_215 at #478 - 10304809_24_215 at #479 10304809_24_215 at #479 - 10304809_24_215 at #480: R99 10304809_24_215 at #480: R99 R 10304809_24_215 at #481: S100 10304809_24_215 at #481: S100 S 10304809_24_215 at #482: G101 10304809_24_215 at #482: G101 G 10304809_24_215 at #483: Q102 10304809_24_215 at #483: Q102 Q 10304809_24_215 at #484: L103 10304809_24_215 at #484: L103 L 10304809_24_215 at #485: F104 10304809_24_215 at #485: F104 F 10304809_24_215 at #486: S105 10304809_24_215 at #486: S105 S 10304809_24_215 at #487: Q106 10304809_24_215 at #487: Q106 Q 10304809_24_215 at #530: I112 10304809_24_215 at #530: I112 I 10304809_24_215 at #532: P114 10304809_24_215 at #532: P114 P 10304809_24_215 at #533: K115 10304809_24_215 at #533: K115 K 10304809_24_215 at #534: D116 10304809_24_215 at #534: D116 D 10304809_24_215 at #535: K117 10304809_24_215 at #535: K117 K 10304809_24_215 at #544: L118 10304809_24_215 at #544: L118 L 10304809_24_215 at #545: A119 10304809_24_215 at #545: A119 A 10304809_24_215 at #548: S120 10304809_24_215 at #548: S120 S 10304809_24_215 at #549: S121 10304809_24_215 at #549: S121 S 10304809_24_215 at #550: S122 10304809_24_215 at #550: S122 S 10304809_24_215 at #551: A123 10304809_24_215 at #551: A123 A 10304809_24_215 at #552: M124 10304809_24_215 at #552: M124 M 10304809_24_215 at #553: K125 10304809_24_215 at #553: K125 K 10304809_24_215 at #554: N126 10304809_24_215 at #554: N126 N 10304809_24_215 at #555: G127 10304809_24_215 at #555: G127 G 10304809_24_215 at #556: E128 10304809_24_215 at #556: E128 E 10304809_24_215 at #557: W129 10304809_24_215 at #557: W129 W 10304809_24_215 at #558: N130 10304809_24_215 at #558: N130 N 10304809_24_215 at #559: T131 10304809_24_215 at #559: T131 T 10304809_24_215 at #560: L132 10304809_24_215 at #560: L132 L 10304809_24_215 at #561: R133 10304809_24_215 at #561: R133 R 10304809_24_215 at #562: V134 10304809_24_215 at #562: V134 V 10304809_24_215 at #565: L135 10304809_24_215 at #565: L135 L 10304809_24_215 at #566: A136 10304809_24_215 at #566: A136 A 10304809_24_215 at #568: V137 10304809_24_215 at #568: V137 V 10304809_24_215 at #570: G138 10304809_24_215 at #570: G138 G 10304809_24_215 at #571: P139 10304809_24_215 at #571: P139 P 10304809_24_215 at #572: R140 10304809_24_215 at #572: R140 R 10304809_24_215 at #588: I141 10304809_24_215 at #588: I141 I 10304809_24_215 at #589: Q142 10304809_24_215 at #589: Q142 Q 10304809_24_215 at #592: T143 10304809_24_215 at #592: T143 T 10304809_24_215 at #594: W144 10304809_24_215 at #594: W144 W 10304809_24_215 at #595: V145 10304809_24_215 at #595: V145 V 10304809_24_215 at #596: N146 10304809_24_215 at #596: N146 N 10304809_24_215 at #598: G147 10304809_24_215 at #598: G147 G 10304809_24_215 at #599: Q148 10304809_24_215 at #599: Q148 Q 10304809_24_215 at #600: Q149 10304809_24_215 at #600: Q149 Q 10304809_24_215 at #601: I150 10304809_24_215 at #601: I150 I 10304809_24_215 at #602: A151 10304809_24_215 at #602: A151 A 10304809_24_215 at #603: D152 10304809_24_215 at #603: D152 D 10304809_24_215 at #604: V153 10304809_24_215 at #604: V153 V 10304809_24_215 at #605: T154 10304809_24_215 at #605: T154 T 10304809_24_215 at #606: D155 10304809_24_215 at #606: D155 D 10304809_24_215 at #607: E156 10304809_24_215 at #607: E156 E 10304809_24_215 at #608: E157 10304809_24_215 at #608: E157 E 10304809_24_215 at #609: A158 10304809_24_215 at #609: A158 A 10304809_24_215 at #610: Y159 10304809_24_215 at #610: Y159 Y 10304809_24_215 at #611: A160 10304809_24_215 at #611: A160 A 10304809_24_215 at #612: K161 10304809_24_215 at #612: K161 K 10304809_24_215 at #613: Y162 10304809_24_215 at #613: Y162 Y 10304809_24_215 at #614 10304809_24_215 at #614 - 10304809_24_215 at #615 10304809_24_215 at #615 - 10304809_24_215 at #616 10304809_24_215 at #616 - 10304809_24_215 at #640 10304809_24_215 at #640 - 10304809_24_215 at #641 10304809_24_215 at #641 - 10304809_24_215 at #642 10304809_24_215 at #642 - 10304809_24_215 at #643: P163 10304809_24_215 at #643: P163 P 10304809_24_215 at #644: S164 10304809_24_215 at #644: S164 S 10304809_24_215 at #645: G165 10304809_24_215 at #645: G165 G 10304809_24_215 at #646: V166 10304809_24_215 at #646: V166 V 10304809_24_215 at #647: I167 10304809_24_215 at #647: I167 I 10304809_24_215 at #648: A168 10304809_24_215 at #648: A168 A 10304809_24_215 at #649: L169 10304809_24_215 at #649: L169 L 10304809_24_215 at #650: Q170 10304809_24_215 at #650: Q170 Q 10304809_24_215 at #653: V171 10304809_24_215 at #653: V171 V 10304809_24_215 at #654: H172 10304809_24_215 at #654: H172 H 10304809_24_215 at #655: G173 10304809_24_215 at #655: G173 G 10304809_24_215 at #668: R182 10304809_24_215 at #668: R182 R 10304809_24_215 at #689: H183 10304809_24_215 at #689: H183 H 10304809_24_215 at #690: V184 10304809_24_215 at #690: V184 V 10304809_24_215 at #691: S185 10304809_24_215 at #691: S185 S 10304809_24_215 at #694: F186 10304809_24_215 at #694: F186 F 10304809_24_215 at #695: R187 10304809_24_215 at #695: R187 R 10304809_24_215 at #696: S188 10304809_24_215 at #696: S188 S 10304809_24_215 at #697: I189 10304809_24_215 at #697: I189 I 10304809_24_215 at #698: R190 10304809_24_215 at #698: R190 R 10304809_24_215 at #699: I191 10304809_24_215 at #699: I191 I 10304809_24_215 at #700: R192 10304809_24_215 at #700: R192 R with redox domain, from Coraliomargarita akajimensis DSM 45221 10359243_331_522 with redox domain, from Coraliomargarita akajimensis DSM 45221 10359243_331_522 at #155: G1 10359243_331_522 at #155: G1 G 10359243_331_522 at #156: W2 10359243_331_522 at #156: W2 W 10359243_331_522 at #157: I3 10359243_331_522 at #157: I3 I 10359243_331_522 at #158: Q4 10359243_331_522 at #158: Q4 Q 10359243_331_522 at #159: L5 10359243_331_522 at #159: L5 L 10359243_331_522 at #160: F6 10359243_331_522 at #160: F6 F 10359243_331_522 at #162: D7 10359243_331_522 at #162: D7 D 10359243_331_522 at #164: G8 10359243_331_522 at #164: G8 G 10359243_331_522 at #165: K9 10359243_331_522 at #165: K9 K 10359243_331_522 at #168: S10 10359243_331_522 at #168: S10 S 10359243_331_522 at #169: L11 10359243_331_522 at #169: L11 L 10359243_331_522 at #171: K12 10359243_331_522 at #171: K12 K 10359243_331_522 at #172: G13 10359243_331_522 at #172: G13 G 10359243_331_522 at #180: W14 10359243_331_522 at #180: W14 W 10359243_331_522 at #181: T15 10359243_331_522 at #181: T15 T 10359243_331_522 at #185: Q16 10359243_331_522 at #185: Q16 Q 10359243_331_522 at #186: R17 10359243_331_522 at #186: R17 R 10359243_331_522 at #187: D18 10359243_331_522 at #187: D18 D 10359243_331_522 at #188: G19 10359243_331_522 at #188: G19 G 10359243_331_522 at #189: K20 10359243_331_522 at #189: K20 K 10359243_331_522 at #190: A21 10359243_331_522 at #190: A21 A 10359243_331_522 at #191: T22 10359243_331_522 at #191: T22 T 10359243_331_522 at #195: Y23 10359243_331_522 at #195: Y23 Y 10359243_331_522 at #196: E24 10359243_331_522 at #196: E24 E 10359243_331_522 at #197 10359243_331_522 at #197 - 10359243_331_522 at #198 10359243_331_522 at #198 - 10359243_331_522 at #235 10359243_331_522 at #235 - 10359243_331_522 at #236: V25 10359243_331_522 at #236: V25 V 10359243_331_522 at #237: R26 10359243_331_522 at #237: R26 R 10359243_331_522 at #238: D27 10359243_331_522 at #238: D27 D 10359243_331_522 at #240: G28 10359243_331_522 at #240: G28 G 10359243_331_522 at #268: A29 10359243_331_522 at #268: A29 A 10359243_331_522 at #269: I30 10359243_331_522 at #269: I30 I 10359243_331_522 at #270: V31 10359243_331_522 at #270: V31 V 10359243_331_522 at #294: S34 10359243_331_522 at #294: S34 S 10359243_331_522 at #295: A35 10359243_331_522 at #295: A35 A 10359243_331_522 at #296: L36 10359243_331_522 at #296: L36 L 10359243_331_522 at #297: A37 10359243_331_522 at #297: A37 A 10359243_331_522 at #298: T38 10359243_331_522 at #298: T38 T 10359243_331_522 at #299: P39 10359243_331_522 at #299: P39 P 10359243_331_522 at #300: N40 10359243_331_522 at #300: N40 N 10359243_331_522 at #301: S41 10359243_331_522 at #301: S41 S 10359243_331_522 at #303: F42 10359243_331_522 at #303: F42 F 10359243_331_522 at #304: L43 10359243_331_522 at #304: L43 L 10359243_331_522 at #305: C44 10359243_331_522 at #305: C44 C 10359243_331_522 at #306: T45 10359243_331_522 at #306: T45 T 10359243_331_522 at #312: E46 10359243_331_522 at #312: E46 E 10359243_331_522 at #318: Q47 10359243_331_522 at #318: Q47 Q 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory