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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11127954_46_240: single domain, from Aquiflexum balticum BA160, DSM 16537 (has NQE) 352996_22_206: tandem domain, near sugar dehydrogenase, from Bacteroides thetaiotaomicron VPI-5482 (has NQE) 11202178_22_203: tandem domain, near sugar dehydrogenase, from Cytophaga fermentans IAM 14302, DSM 9555 (has NQE) BT2157 has N at position 134 (alignment position 385)N134 11127954_46_240 has N65 QE 352996_22_206 has N64 QE 11202178_22_203 has N64 QE 11127954_46_240 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11127954_46_240 has N Q87 E 352996_22_206 has N Q86 E 11202178_22_203 has N Q84 E 11127954_46_240 and 2 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 11127954_46_240 has NQ E89 352996_22_206 has NQ E88 11202178_22_203 has NQ E86 11127954_46_240 and 2 similar proteins have E aligning to 166E 11127954_46_240: single domain, from Aquiflexum balticum BA160, DSM 16537 11127954_46_24011127954_46_240: single domain, from Aquiflexum balticum BA160, DSM 16537 0.000 352996_22_206: tandem domain, near sugar dehydrogenase, from Bacteroides thetaiotaomicron VPI-5482 352996_22_206352996_22_206: tandem domain, near sugar dehydrogenase, from Bacteroides thetaiotaomicron VPI-5482 11202178_22_203: tandem domain, near sugar dehydrogenase, from Cytophaga fermentans IAM 14302, DSM 9555 11202178_22_20311202178_22_203: tandem domain, near sugar dehydrogenase, from Cytophaga fermentans IAM 14302, DSM 9555 11127954_46_240: single domain, from Aquiflexum balticum BA160, DSM 16537 (has NQE)11127954_46_240 single domain, from Aquiflexum balticum BA160, DSM 16537 352996_22_206: tandem domain, near sugar dehydrogenase, from Bacteroides thetaiotaomicron VPI-5482 (has NQE)352996_22_206 tandem domain, near sugar dehydrogenase, from Bacteroides thetaiotaomicron VPI-5482 11202178_22_203: tandem domain, near sugar dehydrogenase, from Cytophaga fermentans IAM 14302, DSM 9555 (has NQE)11202178_22_203 tandem domain, near sugar dehydrogenase, from Cytophaga fermentans IAM 14302, DSM 9555 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory