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Zoomed into a clade of 3 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10307987_154_329: single domain, from Pirellula staleyi DSM 6068 (has NEQ) 4616236_34_216: single domain, from Lentisphaera araneosa HTCC2155 (has NEQ) 557181_269_442: single domain, from Pirellula sp. 1 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 10307987_154_329 has N57 EQ 4616236_34_216 has N63 EQ 557181_269_442 has N56 EQ 10307987_154_329 and 2 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 10307987_154_329 has N E67 Q 4616236_34_216 has N E73 Q 557181_269_442 has N E66 Q 10307987_154_329 and 2 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 10307987_154_329 has NE Q69 4616236_34_216 has NE Q75 557181_269_442 has NE Q68 10307987_154_329 and 2 similar proteins have Q aligning to 166Q 0.840 10307987_154_329: single domain, from Pirellula staleyi DSM 6068 10307987_154_32910307987_154_329: single domain, from Pirellula staleyi DSM 6068 4616236_34_216: single domain, from Lentisphaera araneosa HTCC2155 4616236_34_2164616236_34_216: single domain, from Lentisphaera araneosa HTCC2155 557181_269_442: single domain, from Pirellula sp. 1 557181_269_442557181_269_442: single domain, from Pirellula sp. 1 10307987_154_329: single domain, from Pirellula staleyi DSM 6068 (has NEQ)10307987_154_329 single domain, from Pirellula staleyi DSM 6068 4616236_34_216: single domain, from Lentisphaera araneosa HTCC2155 (has NEQ)4616236_34_216 single domain, from Lentisphaera araneosa HTCC2155 557181_269_442: single domain, from Pirellula sp. 1 (has NEQ)557181_269_442 single domain, from Pirellula sp. 1 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory