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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

556011_29_219: tandem domain, from Pirellula sp. 1 (has NQE) 10359233_59_249: tandem domain, from Coraliomargarita akajimensis DSM 45221 (has NQE) 4615012_42_228: single domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has NQE) 554419_49_246: with other domain, from Pirellula sp. 1 (has NQE) 559162_54_228: tandem domain, from Pirellula sp. 1 (has NQE) BT2157 has N at position 134 (alignment position 385)N134 556011_29_219 has N66 QE 10359233_59_249 has N65 QE 4615012_42_228 has N45 QE 554419_49_246 has N63 QE 559162_54_228 has N62 QE 556011_29_219 and 4 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 556011_29_219 has N Q88 E 10359233_59_249 has N Q89 E 4615012_42_228 has N Q67 E 554419_49_246 has N Q84 E 559162_54_228 has N Q80 E 556011_29_219 and 4 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 556011_29_219 has NQ E90 10359233_59_249 has NQ E91 4615012_42_228 has NQ E69 554419_49_246 has NQ E86 559162_54_228 has NQ E82 556011_29_219 and 4 similar proteins have E aligning to 166E 0.068 556011_29_219: tandem domain, from Pirellula sp. 1 556011_29_219556011_29_219: tandem domain, from Pirellula sp. 1 10359233_59_249: tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_59_24910359233_59_249: tandem domain, from Coraliomargarita akajimensis DSM 45221 0.952 4615012_42_228: single domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4615012_42_2284615012_42_228: single domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 0.941 554419_49_246: with other domain, from Pirellula sp. 1 554419_49_246554419_49_246: with other domain, from Pirellula sp. 1 559162_54_228: tandem domain, from Pirellula sp. 1 559162_54_228559162_54_228: tandem domain, from Pirellula sp. 1 556011_29_219: tandem domain, from Pirellula sp. 1 (has NQE)556011_29_219 tandem domain, from Pirellula sp. 1 10359233_59_249: tandem domain, from Coraliomargarita akajimensis DSM 45221 (has NQE)10359233_59_249 tandem domain, from Coraliomargarita akajimensis DSM 45221 4615012_42_228: single domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has NQE)4615012_42_228 single domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 554419_49_246: with other domain, from Pirellula sp. 1 (has NQE)554419_49_246 with other domain, from Pirellula sp. 1 559162_54_228: tandem domain, from Pirellula sp. 1 (has NQE)559162_54_228 tandem domain, from Pirellula sp. 1 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory