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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.068 556011_29_219: tandem domain, from Pirellula sp. 1 10359233_59_249: tandem domain, from Coraliomargarita akajimensis DSM 45221 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 tandem domain, from Pirellula sp. 1 556011_29_219 tandem domain, from Pirellula sp. 1 556011_29_219 at #155: G1 556011_29_219 at #155: G1 G 556011_29_219 at #156: F2 556011_29_219 at #156: F2 F 556011_29_219 at #157: V3 556011_29_219 at #157: V3 V 556011_29_219 at #158: S4 556011_29_219 at #158: S4 S 556011_29_219 at #159: L5 556011_29_219 at #159: L5 L 556011_29_219 at #160: F6 556011_29_219 at #160: F6 F 556011_29_219 at #162: N7 556011_29_219 at #162: N7 N 556011_29_219 at #164: G8 556011_29_219 at #164: G8 G 556011_29_219 at #165: S9 556011_29_219 at #165: S9 S 556011_29_219 at #168: D10 556011_29_219 at #168: D10 D 556011_29_219 at #169: L11 556011_29_219 at #169: L11 L 556011_29_219 at #171: S12 556011_29_219 at #171: S12 S 556011_29_219 at #172: G13 556011_29_219 at #172: G13 G 556011_29_219 at #180: W14 556011_29_219 at #180: W14 W 556011_29_219 at #181: V15 556011_29_219 at #181: V15 V 556011_29_219 at #185: K16 556011_29_219 at #185: K16 K 556011_29_219 at #186: R17 556011_29_219 at #186: R17 R 556011_29_219 at #187: G18 556011_29_219 at #187: G18 G 556011_29_219 at #188: G19 556011_29_219 at #188: G19 G 556011_29_219 at #189: S20 556011_29_219 at #189: S20 S 556011_29_219 at #190: A21 556011_29_219 at #190: A21 A 556011_29_219 at #191: K22 556011_29_219 at #191: K22 K 556011_29_219 at #195: Y23 556011_29_219 at #195: Y23 Y 556011_29_219 at #196 556011_29_219 at #196 - 556011_29_219 at #197 556011_29_219 at #197 - 556011_29_219 at #198 556011_29_219 at #198 - 556011_29_219 at #235: R24 556011_29_219 at #235: R24 R 556011_29_219 at #236: V25 556011_29_219 at #236: V25 V 556011_29_219 at #237: E26 556011_29_219 at #237: E26 E 556011_29_219 at #238: D27 556011_29_219 at #238: D27 D 556011_29_219 at #240: G28 556011_29_219 at #240: G28 G 556011_29_219 at #268: V29 556011_29_219 at #268: V29 V 556011_29_219 at #269: I30 556011_29_219 at #269: I30 I 556011_29_219 at #270: V31 556011_29_219 at #270: V31 V 556011_29_219 at #294: A35 556011_29_219 at #294: A35 A 556011_29_219 at #295: P36 556011_29_219 at #295: P36 P 556011_29_219 at #296: N37 556011_29_219 at #296: N37 N 556011_29_219 at #297: T38 556011_29_219 at #297: T38 T 556011_29_219 at #298: P39 556011_29_219 at #298: P39 P 556011_29_219 at #299: G40 556011_29_219 at #299: G40 G 556011_29_219 at #300: N41 556011_29_219 at #300: N41 N 556011_29_219 at #301: T42 556011_29_219 at #301: T42 T 556011_29_219 at #303: F43 556011_29_219 at #303: F43 F 556011_29_219 at #304: L44 556011_29_219 at #304: L44 L 556011_29_219 at #305: C45 556011_29_219 at #305: C45 C 556011_29_219 at #306: S46 556011_29_219 at #306: S46 S 556011_29_219 at #312: D47 556011_29_219 at #312: D47 D 556011_29_219 at #318: K48 556011_29_219 at #318: K48 K 556011_29_219 at #321: E49 556011_29_219 at #321: E49 E 556011_29_219 at #322: F50 556011_29_219 at #322: F50 F 556011_29_219 at #324: G51 556011_29_219 at #324: G51 G 556011_29_219 at #326: D52 556011_29_219 at #326: D52 D 556011_29_219 at #327: F53 556011_29_219 at #327: F53 F 556011_29_219 at #328: V54 556011_29_219 at #328: V54 V 556011_29_219 at #329: L55 556011_29_219 at #329: L55 L 556011_29_219 at #330: K56 556011_29_219 at #330: K56 K 556011_29_219 at #331: L57 556011_29_219 at #331: L57 L 556011_29_219 at #332: R58 556011_29_219 at #332: R58 R 556011_29_219 at #333: Y59 556011_29_219 at #333: Y59 Y 556011_29_219 at #334: K60 556011_29_219 at #334: K60 K 556011_29_219 at #335: F61 556011_29_219 at #335: F61 F 556011_29_219 at #351: L62 556011_29_219 at #351: L62 L 556011_29_219 at #352: E63 556011_29_219 at #352: E63 E 556011_29_219 at #354: S64 556011_29_219 at #354: S64 S 556011_29_219 at #355: G65 556011_29_219 at #355: G65 G 556011_29_219 at #385: N66 556011_29_219 at #385: N66 N 556011_29_219 at #386: S67 556011_29_219 at #386: S67 S 556011_29_219 at #387: G68 556011_29_219 at #387: G68 G 556011_29_219 at #388: V69 556011_29_219 at #388: V69 V 556011_29_219 at #389: Q70 556011_29_219 at #389: Q70 Q 556011_29_219 at #390: F71 556011_29_219 at #390: F71 F 556011_29_219 at #391: R72 556011_29_219 at #391: R72 R 556011_29_219 at #392: S73 556011_29_219 at #392: S73 S 556011_29_219 at #393: A74 556011_29_219 at #393: A74 A 556011_29_219 at #423: E77 556011_29_219 at #423: E77 E 556011_29_219 at #424: E78 556011_29_219 at #424: E78 E 556011_29_219 at #425: G79 556011_29_219 at #425: G79 G 556011_29_219 at #426: D80 556011_29_219 at #426: D80 D 556011_29_219 at #430: R81 556011_29_219 at #430: R81 R 556011_29_219 at #431: Q82 556011_29_219 at #431: Q82 Q 556011_29_219 at #432: R83 556011_29_219 at #432: R83 R 556011_29_219 at #433: V84 556011_29_219 at #433: V84 V 556011_29_219 at #434: F85 556011_29_219 at #434: F85 F 556011_29_219 at #435: G86 556011_29_219 at #435: G86 G 556011_29_219 at #436: Y87 556011_29_219 at #436: Y87 Y 556011_29_219 at #438: Q88 556011_29_219 at #438: Q88 Q 556011_29_219 at #439: A89 556011_29_219 at #439: A89 A 556011_29_219 at #440: E90 556011_29_219 at #440: E90 E 556011_29_219 at #441: M91 556011_29_219 at #441: M91 M 556011_29_219 at #442: R92 556011_29_219 at #442: R92 R 556011_29_219 at #443: P93 556011_29_219 at #443: P93 P 556011_29_219 at #450: G94 556011_29_219 at #450: G94 G 556011_29_219 at #451: G95 556011_29_219 at #451: G95 G 556011_29_219 at #452: D96 556011_29_219 at #452: D96 D 556011_29_219 at #453: M97 556011_29_219 at #453: M97 M 556011_29_219 at #475 556011_29_219 at #475 - 556011_29_219 at #476 556011_29_219 at #476 - 556011_29_219 at #477 556011_29_219 at #477 - 556011_29_219 at #478 556011_29_219 at #478 - 556011_29_219 at #479 556011_29_219 at #479 - 556011_29_219 at #480 556011_29_219 at #480 - 556011_29_219 at #481: T98 556011_29_219 at #481: T98 T 556011_29_219 at #482: G99 556011_29_219 at #482: G99 G 556011_29_219 at #483: R100 556011_29_219 at #483: R100 R 556011_29_219 at #484: I101 556011_29_219 at #484: I101 I 556011_29_219 at #485: Y102 556011_29_219 at #485: Y102 Y 556011_29_219 at #486: D103 556011_29_219 at #486: D103 D 556011_29_219 at #487: E104 556011_29_219 at #487: E104 E 556011_29_219 at #530: T120 556011_29_219 at #530: T120 T 556011_29_219 at #532: Q122 556011_29_219 at #532: Q122 Q 556011_29_219 at #533: E123 556011_29_219 at #533: E123 E 556011_29_219 at #534: R124 556011_29_219 at #534: R124 R 556011_29_219 at #535: L125 556011_29_219 at #535: L125 L 556011_29_219 at #544: D126 556011_29_219 at #544: D126 D 556011_29_219 at #545: A127 556011_29_219 at #545: A127 A 556011_29_219 at #548: A128 556011_29_219 at #548: A128 A 556011_29_219 at #549: Q129 556011_29_219 at #549: Q129 Q 556011_29_219 at #550: E130 556011_29_219 at #550: E130 E 556011_29_219 at #551: S131 556011_29_219 at #551: S131 S 556011_29_219 at #552: C132 556011_29_219 at #552: C132 C 556011_29_219 at #553: R133 556011_29_219 at #553: R133 R 556011_29_219 at #554: P134 556011_29_219 at #554: P134 P 556011_29_219 at #555: G135 556011_29_219 at #555: G135 G 556011_29_219 at #556: E136 556011_29_219 at #556: E136 E 556011_29_219 at #557: W137 556011_29_219 at #557: W137 W 556011_29_219 at #558: N138 556011_29_219 at #558: N138 N 556011_29_219 at #559: D139 556011_29_219 at #559: D139 D 556011_29_219 at #560: L140 556011_29_219 at #560: L140 L 556011_29_219 at #561: E141 556011_29_219 at #561: E141 E 556011_29_219 at #562: I142 556011_29_219 at #562: I142 I 556011_29_219 at #565: Q143 556011_29_219 at #565: Q143 Q 556011_29_219 at #566: C144 556011_29_219 at #566: C144 C 556011_29_219 at #568: V145 556011_29_219 at #568: V145 V 556011_29_219 at #570: G146 556011_29_219 at #570: G146 G 556011_29_219 at #571: P147 556011_29_219 at #571: P147 P 556011_29_219 at #572: S148 556011_29_219 at #572: S148 S 556011_29_219 at #588: I149 556011_29_219 at #588: I149 I 556011_29_219 at #589: K150 556011_29_219 at #589: K150 K 556011_29_219 at #592: T151 556011_29_219 at #592: T151 T 556011_29_219 at #594: W152 556011_29_219 at #594: W152 W 556011_29_219 at #595: L153 556011_29_219 at #595: L153 L 556011_29_219 at #596: N154 556011_29_219 at #596: N154 N 556011_29_219 at #598: G155 556011_29_219 at #598: G155 G 556011_29_219 at #599: N156 556011_29_219 at #599: N156 N 556011_29_219 at #600: L157 556011_29_219 at #600: L157 L 556011_29_219 at #601: V158 556011_29_219 at #601: V158 V 556011_29_219 at #602: V159 556011_29_219 at #602: V159 V 556011_29_219 at #603: D160 556011_29_219 at #603: D160 D 556011_29_219 at #604: I161 556011_29_219 at #604: I161 I 556011_29_219 at #605: F162 556011_29_219 at #605: F162 F 556011_29_219 at #606: D163 556011_29_219 at #606: D163 D 556011_29_219 at #607: S164 556011_29_219 at #607: S164 S 556011_29_219 at #608: F165 556011_29_219 at #608: F165 F 556011_29_219 at #609: S166 556011_29_219 at #609: S166 S 556011_29_219 at #610 556011_29_219 at #610 - 556011_29_219 at #611 556011_29_219 at #611 - 556011_29_219 at #612 556011_29_219 at #612 - 556011_29_219 at #613 556011_29_219 at #613 - 556011_29_219 at #614 556011_29_219 at #614 - 556011_29_219 at #615 556011_29_219 at #615 - 556011_29_219 at #616 556011_29_219 at #616 - 556011_29_219 at #640 556011_29_219 at #640 - 556011_29_219 at #641 556011_29_219 at #641 - 556011_29_219 at #642 556011_29_219 at #642 - 556011_29_219 at #643: M167 556011_29_219 at #643: M167 M 556011_29_219 at #644: K168 556011_29_219 at #644: K168 K 556011_29_219 at #645: G169 556011_29_219 at #645: G169 G 556011_29_219 at #646: F170 556011_29_219 at #646: F170 F 556011_29_219 at #647: I171 556011_29_219 at #647: I171 I 556011_29_219 at #648: G172 556011_29_219 at #648: G172 G 556011_29_219 at #649: L173 556011_29_219 at #649: L173 L 556011_29_219 at #650: Q174 556011_29_219 at #650: Q174 Q 556011_29_219 at #653: I175 556011_29_219 at #653: I175 I 556011_29_219 at #654: H176 556011_29_219 at #654: H176 H 556011_29_219 at #655: S177 556011_29_219 at #655: S177 S 556011_29_219 at #668: G181 556011_29_219 at #668: G181 G 556011_29_219 at #689: S182 556011_29_219 at #689: S182 S 556011_29_219 at #690: V183 556011_29_219 at #690: V183 V 556011_29_219 at #691: A184 556011_29_219 at #691: A184 A 556011_29_219 at #694: W185 556011_29_219 at #694: W185 W 556011_29_219 at #695: K186 556011_29_219 at #695: K186 K 556011_29_219 at #696: D187 556011_29_219 at #696: D187 D 556011_29_219 at #697: I188 556011_29_219 at #697: I188 I 556011_29_219 at #698: R189 556011_29_219 at #698: R189 R 556011_29_219 at #699: V190 556011_29_219 at #699: V190 V 556011_29_219 at #700: K191 556011_29_219 at #700: K191 K tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_59_249 tandem domain, from Coraliomargarita akajimensis DSM 45221 10359233_59_249 at #155: G1 10359233_59_249 at #155: G1 G 10359233_59_249 at #156: F2 10359233_59_249 at #156: F2 F 10359233_59_249 at #157: V3 10359233_59_249 at #157: V3 V 10359233_59_249 at #158: S4 10359233_59_249 at #158: S4 S 10359233_59_249 at #159: L5 10359233_59_249 at #159: L5 L 10359233_59_249 at #160: Y6 10359233_59_249 at #160: Y6 Y 10359233_59_249 at #162: N7 10359233_59_249 at #162: N7 N 10359233_59_249 at #164: G8 10359233_59_249 at #164: G8 G 10359233_59_249 at #165: K9 10359233_59_249 at #165: K9 K 10359233_59_249 at #168: D10 10359233_59_249 at #168: D10 D 10359233_59_249 at #169: L11 10359233_59_249 at #169: L11 L 10359233_59_249 at #171: E12 10359233_59_249 at #171: E12 E 10359233_59_249 at #172: G13 10359233_59_249 at #172: G13 G 10359233_59_249 at #180: W14 10359233_59_249 at #180: W14 W 10359233_59_249 at #181: T15 10359233_59_249 at #181: T15 T 10359233_59_249 at #185: P16 10359233_59_249 at #185: P16 P 10359233_59_249 at #186: R17 10359233_59_249 at #186: R17 R 10359233_59_249 at #187: G18 10359233_59_249 at #187: G18 G 10359233_59_249 at #188: G19 10359233_59_249 at #188: G19 G 10359233_59_249 at #189: A20 10359233_59_249 at #189: A20 A 10359233_59_249 at #190: C21 10359233_59_249 at #190: C21 C 10359233_59_249 at #191: T22 10359233_59_249 at #191: T22 T 10359233_59_249 at #195: E24 10359233_59_249 at #195: E24 E 10359233_59_249 at #196 10359233_59_249 at #196 - 10359233_59_249 at #197 10359233_59_249 at #197 - 10359233_59_249 at #198 10359233_59_249 at #198 - 10359233_59_249 at #235 10359233_59_249 at #235 - 10359233_59_249 at #236: A25 10359233_59_249 at #236: A25 A 10359233_59_249 at #237: R26 10359233_59_249 at #237: R26 R 10359233_59_249 at #238: G27 10359233_59_249 at #238: G27 G 10359233_59_249 at #240: E28 10359233_59_249 at #240: E28 E 10359233_59_249 at #268: V29 10359233_59_249 at #268: V29 V 10359233_59_249 at #269: I30 10359233_59_249 at #269: I30 I 10359233_59_249 at #270: V31 10359233_59_249 at #270: V31 V 10359233_59_249 at #294: C34 10359233_59_249 at #294: C34 C 10359233_59_249 at #295: V35 10359233_59_249 at #295: V35 V 10359233_59_249 at #296: Q36 10359233_59_249 at #296: Q36 Q 10359233_59_249 at #297: G37 10359233_59_249 at #297: G37 G 10359233_59_249 at #298: S38 10359233_59_249 at #298: S38 S 10359233_59_249 at #299: P39 10359233_59_249 at #299: P39 P 10359233_59_249 at #300: S40 10359233_59_249 at #300: S40 S 10359233_59_249 at #301: T41 10359233_59_249 at #301: T41 T 10359233_59_249 at #303: Y42 10359233_59_249 at #303: Y42 Y 10359233_59_249 at #304: L43 10359233_59_249 at #304: L43 L 10359233_59_249 at #305: S44 10359233_59_249 at #305: S44 S 10359233_59_249 at #306: T45 10359233_59_249 at #306: T45 T 10359233_59_249 at #312: D46 10359233_59_249 at #312: D46 D 10359233_59_249 at #318: K47 10359233_59_249 at #318: K47 K 10359233_59_249 at #321: D48 10359233_59_249 at #321: D48 D 10359233_59_249 at #322: Y49 10359233_59_249 at #322: Y49 Y 10359233_59_249 at #324: G50 10359233_59_249 at #324: G50 G 10359233_59_249 at #326: D51 10359233_59_249 at #326: D51 D 10359233_59_249 at #327: F52 10359233_59_249 at #327: F52 F 10359233_59_249 at #328: I53 10359233_59_249 at #328: I53 I 10359233_59_249 at #329: F54 10359233_59_249 at #329: F54 F 10359233_59_249 at #330: T55 10359233_59_249 at #330: T55 T 10359233_59_249 at #331: A56 10359233_59_249 at #331: A56 A 10359233_59_249 at #332: E57 10359233_59_249 at #332: E57 E 10359233_59_249 at #333: L58 10359233_59_249 at #333: L58 L 10359233_59_249 at #334: N59 10359233_59_249 at #334: N59 N 10359233_59_249 at #335: W60 10359233_59_249 at #335: W60 W 10359233_59_249 at #351: V61 10359233_59_249 at #351: V61 V 10359233_59_249 at #352: V62 10359233_59_249 at #352: V62 V 10359233_59_249 at #354: D63 10359233_59_249 at #354: D63 D 10359233_59_249 at #355: G64 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory