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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2221624_159_350: single domain, from Solibacter usitatus Ellin6076 (has NEN) 7460876_127_321: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 (has NEN) BT2157 has N at position 134 (alignment position 385)N134 2221624_159_350 has N70 EN 7460876_127_321 has N71 EN 2221624_159_350 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2221624_159_350 has N E80 N 7460876_127_321 has N E81 N 2221624_159_350 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 2221624_159_350 has NE N82 7460876_127_321 has NE N83 2221624_159_350 and 1 similar proteins have N aligning to 166N 2221624_159_350: single domain, from Solibacter usitatus Ellin6076 2221624_159_3502221624_159_350: single domain, from Solibacter usitatus Ellin6076 7460876_127_321: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 7460876_127_3217460876_127_321: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 2221624_159_350: single domain, from Solibacter usitatus Ellin6076 (has NEN)2221624_159_350 single domain, from Solibacter usitatus Ellin6076 7460876_127_321: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 (has NEN)7460876_127_321 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory