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Zoomed into a clade of 5 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 (has DQQ) 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 (has DQQ) 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has DQQ) 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 (has DQQ) 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 (has DQQ) BT2157 has N at position 134 (alignment position 385)N134 7462545_728_927 has D89 QQ 2223539_22_227 has D90 QQ 4614159_234_440 has D92 QQ 4908012_29_247 has D85 QQ 11292817_33_232 has D83 QQ 7462545_728_927 and 4 similar proteins have D aligning to 134D BT2157 has E at position 164 (alignment position 438)E164 7462545_728_927 has D Q99 Q 2223539_22_227 has D Q100 Q 4614159_234_440 has D Q102 Q 4908012_29_247 has D Q95 Q 11292817_33_232 has D Q93 Q 7462545_728_927 and 4 similar proteins have Q aligning to 164Q BT2157 has Q at position 166 (alignment position 440)Q166 7462545_728_927 has DQ Q101 2223539_22_227 has DQ Q102 4614159_234_440 has DQ Q104 4908012_29_247 has DQ Q97 11292817_33_232 has DQ Q95 7462545_728_927 and 4 similar proteins have Q aligning to 166Q 0.744 7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 7462545_728_9277462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 0.758 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 2223539_22_2272223539_22_227: single domain, from Solibacter usitatus Ellin6076 0.806 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_234_4404614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 4908012_29_2474908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 11292817_33_23211292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 7462545_728_927: with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 (has DQQ)7462545_728_927 with other domain, near sugar dehydrogenase, from Pedobacter heparinus DSM 2366 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 (has DQQ)2223539_22_227 single domain, from Solibacter usitatus Ellin6076 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 (has DQQ)4614159_234_440 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 (has DQQ)4908012_29_247 single domain, from Gemmata obscuriglobus UQM 2246 11292817_33_232: single domain, from Planctomyces brasiliensis DSM 5305 (has DQQ)11292817_33_232 single domain, from Planctomyces brasiliensis DSM 5305 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory