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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

0.460 0.115 0.876 7398304_63_256: single domain, from Dyadobacter fermentans DSM 18053 0.886 3723559_59_253: single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 0.992 5848954_85_286: single domain, from Caulobacter crescentus NA1000 0.052 Pedo557__CA265_RS22975: single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 11045354_54_254: single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 11293044_51_238: single domain, from Planctomyces brasiliensis DSM 5305 4612339_494_704: with other domain, from Lentisphaera araneosa HTCC2155 0.5 /site single domain, from Dyadobacter fermentans DSM 18053 7398304_63_256 single domain, from Dyadobacter fermentans DSM 18053 single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 3723559_59_253 single domain, near sugar dehydrogenase, from Parabacteroides distasonis ATCC 8503 single domain, from Caulobacter crescentus NA1000 5848954_85_286 single domain, from Caulobacter crescentus NA1000 single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 Pedo557__CA265_RS22975 single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 11045354_54_254 single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 single domain, from Planctomyces brasiliensis DSM 5305 11293044_51_238 single domain, from Planctomyces brasiliensis DSM 5305 with other domain, from Lentisphaera araneosa HTCC2155 4612339_494_704 with other domain, from Lentisphaera araneosa HTCC2155 download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory