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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

Pedo557__CA265_RS22975: single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 (has NEQ) 11045354_54_254: single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 Pedo557__CA265_RS22975 has N126 EQ 11045354_54_254 has N69 EQ Pedo557__CA265_RS22975 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 Pedo557__CA265_RS22975 has N E142 Q 11045354_54_254 has N E85 Q Pedo557__CA265_RS22975 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 Pedo557__CA265_RS22975 has NE Q144 11045354_54_254 has NE Q87 Pedo557__CA265_RS22975 and 1 similar proteins have Q aligning to 166Q Pedo557__CA265_RS22975: single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 Pedo557__CA265_RS22975Pedo557__CA265_RS22975: single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 11045354_54_254: single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 11045354_54_25411045354_54_254: single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 Pedo557__CA265_RS22975: single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 (has NEQ)Pedo557__CA265_RS22975 single domain 3-ketotrehalose hydrolase from Pedobacter sp. GW460-11-11-14-LB5 11045354_54_254: single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 (has NEQ)11045354_54_254 single domain, from Hymenobacter roseosalivarius AA-718, DSM 11622 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory