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Zoomed into a clade of 2 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

10356898_71_256: single domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ) 4614844_78_263: single domain, from Lentisphaera araneosa HTCC2155 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 10356898_71_256 has N63 EQ 4614844_78_263 has N64 EQ 10356898_71_256 and 1 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 10356898_71_256 has N E73 Q 4614844_78_263 has N E74 Q 10356898_71_256 and 1 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 10356898_71_256 has NE Q75 4614844_78_263 has NE Q76 10356898_71_256 and 1 similar proteins have Q aligning to 166Q 10356898_71_256: single domain, from Coraliomargarita akajimensis DSM 45221 10356898_71_25610356898_71_256: single domain, from Coraliomargarita akajimensis DSM 45221 4614844_78_263: single domain, from Lentisphaera araneosa HTCC2155 4614844_78_2634614844_78_263: single domain, from Lentisphaera araneosa HTCC2155 10356898_71_256: single domain, from Coraliomargarita akajimensis DSM 45221 (has NEQ)10356898_71_256 single domain, from Coraliomargarita akajimensis DSM 45221 4614844_78_263: single domain, from Lentisphaera araneosa HTCC2155 (has NEQ)4614844_78_263 single domain, from Lentisphaera araneosa HTCC2155 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory