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Zoomed into a clade of 4 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

2221882_149_317: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 6000697_153_324: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ) 2224728_148_318: single domain, from Solibacter usitatus Ellin6076 (has NEQ) 11127748_199_365: single domain, from Aquiflexum balticum BA160, DSM 16537 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 2221882_149_317 has N62 EQ 6000697_153_324 has N65 EQ 2224728_148_318 has N62 EQ 11127748_199_365 has N60 EQ 2221882_149_317 and 3 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 2221882_149_317 has N E72 Q 6000697_153_324 has N E75 Q 2224728_148_318 has N E72 Q 11127748_199_365 has N E70 Q 2221882_149_317 and 3 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 2221882_149_317 has NE Q74 6000697_153_324 has NE Q77 2224728_148_318 has NE Q74 11127748_199_365 has NE Q72 2221882_149_317 and 3 similar proteins have Q aligning to 166Q 0.774 2221882_149_317: single domain, from Solibacter usitatus Ellin6076 2221882_149_3172221882_149_317: single domain, from Solibacter usitatus Ellin6076 6000697_153_324: single domain, from Verrucomicrobium spinosum DSM 4136 6000697_153_3246000697_153_324: single domain, from Verrucomicrobium spinosum DSM 4136 0.030 2224728_148_318: single domain, from Solibacter usitatus Ellin6076 2224728_148_3182224728_148_318: single domain, from Solibacter usitatus Ellin6076 11127748_199_365: single domain, from Aquiflexum balticum BA160, DSM 16537 11127748_199_36511127748_199_365: single domain, from Aquiflexum balticum BA160, DSM 16537 2221882_149_317: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2221882_149_317 single domain, from Solibacter usitatus Ellin6076 6000697_153_324: single domain, from Verrucomicrobium spinosum DSM 4136 (has NEQ)6000697_153_324 single domain, from Verrucomicrobium spinosum DSM 4136 2224728_148_318: single domain, from Solibacter usitatus Ellin6076 (has NEQ)2224728_148_318 single domain, from Solibacter usitatus Ellin6076 11127748_199_365: single domain, from Aquiflexum balticum BA160, DSM 16537 (has NEQ)11127748_199_365 single domain, from Aquiflexum balticum BA160, DSM 16537 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory