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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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0.774 2221882_149_317: single domain, from Solibacter usitatus Ellin6076 6000697_153_324: single domain, from Verrucomicrobium spinosum DSM 4136 0.2 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Solibacter usitatus Ellin6076 2221882_149_317 single domain, from Solibacter usitatus Ellin6076 2221882_149_317 at #155 2221882_149_317 at #155 - 2221882_149_317 at #156 2221882_149_317 at #156 - 2221882_149_317 at #157: I2 2221882_149_317 at #157: I2 I 2221882_149_317 at #158: E3 2221882_149_317 at #158: E3 E 2221882_149_317 at #159: L4 2221882_149_317 at #159: L4 L 2221882_149_317 at #160: F5 2221882_149_317 at #160: F5 F 2221882_149_317 at #162: N6 2221882_149_317 at #162: N6 N 2221882_149_317 at #164: G7 2221882_149_317 at #164: G7 G 2221882_149_317 at #165: K8 2221882_149_317 at #165: K8 K 2221882_149_317 at #168: D9 2221882_149_317 at #168: D9 D 2221882_149_317 at #169: L10 2221882_149_317 at #169: L10 L 2221882_149_317 at #171: S11 2221882_149_317 at #171: S11 S 2221882_149_317 at #172: G12 2221882_149_317 at #172: G12 G 2221882_149_317 at #180: W13 2221882_149_317 at #180: W13 W 2221882_149_317 at #181: K14 2221882_149_317 at #181: K14 K 2221882_149_317 at #185: P15 2221882_149_317 at #185: P15 P 2221882_149_317 at #186: L16 2221882_149_317 at #186: L16 L 2221882_149_317 at #187: N17 2221882_149_317 at #187: N17 N 2221882_149_317 at #188: P18 2221882_149_317 at #188: P18 P 2221882_149_317 at #189: G19 2221882_149_317 at #189: G19 G 2221882_149_317 at #190: A20 2221882_149_317 at #190: A20 A 2221882_149_317 at #191: E21 2221882_149_317 at #191: E21 E 2221882_149_317 at #195 2221882_149_317 at #195 - 2221882_149_317 at #196: M22 2221882_149_317 at #196: M22 M 2221882_149_317 at #197: K23 2221882_149_317 at #197: K23 K 2221882_149_317 at #198: W24 2221882_149_317 at #198: W24 W 2221882_149_317 at #235: T25 2221882_149_317 at #235: T25 T 2221882_149_317 at #236: V26 2221882_149_317 at #236: V26 V 2221882_149_317 at #237: V27 2221882_149_317 at #237: V27 V 2221882_149_317 at #238: D28 2221882_149_317 at #238: D28 D 2221882_149_317 at #240: G29 2221882_149_317 at #240: G29 G 2221882_149_317 at #268: V30 2221882_149_317 at #268: V30 V 2221882_149_317 at #269: L31 2221882_149_317 at #269: L31 L 2221882_149_317 at #270: R32 2221882_149_317 at #270: R32 R 2221882_149_317 at #294 2221882_149_317 at #294 - 2221882_149_317 at #295 2221882_149_317 at #295 - 2221882_149_317 at #296: N33 2221882_149_317 at #296: N33 N 2221882_149_317 at #297: A34 2221882_149_317 at #297: A34 A 2221882_149_317 at #298: P35 2221882_149_317 at #298: P35 P 2221882_149_317 at #299: P36 2221882_149_317 at #299: P36 P 2221882_149_317 at #300: T37 2221882_149_317 at #300: T37 T 2221882_149_317 at #301: T38 2221882_149_317 at #301: T38 T 2221882_149_317 at #303: D39 2221882_149_317 at #303: D39 D 2221882_149_317 at #304: L40 2221882_149_317 at #304: L40 L 2221882_149_317 at #305: I41 2221882_149_317 at #305: I41 I 2221882_149_317 at #306: S42 2221882_149_317 at #306: S42 S 2221882_149_317 at #312: E43 2221882_149_317 at #312: E43 E 2221882_149_317 at #318: Q44 2221882_149_317 at #318: Q44 Q 2221882_149_317 at #321: K45 2221882_149_317 at #321: K45 K 2221882_149_317 at #322: F46 2221882_149_317 at #322: F46 F 2221882_149_317 at #324: W47 2221882_149_317 at #324: W47 W 2221882_149_317 at #326: N48 2221882_149_317 at #326: N48 N 2221882_149_317 at #327: F49 2221882_149_317 at #327: F49 F 2221882_149_317 at #328: M50 2221882_149_317 at #328: M50 M 2221882_149_317 at #329: L51 2221882_149_317 at #329: L51 L 2221882_149_317 at #330: H52 2221882_149_317 at #330: H52 H 2221882_149_317 at #331: V53 2221882_149_317 at #331: V53 V 2221882_149_317 at #332: D54 2221882_149_317 at #332: D54 D 2221882_149_317 at #333: F55 2221882_149_317 at #333: F55 F 2221882_149_317 at #334: R56 2221882_149_317 at #334: R56 R 2221882_149_317 at #335: I57 2221882_149_317 at #335: I57 I 2221882_149_317 at #351: V58 2221882_149_317 at #351: V58 V 2221882_149_317 at #352: E59 2221882_149_317 at #352: E59 E 2221882_149_317 at #354: H60 2221882_149_317 at #354: H60 H 2221882_149_317 at #355: S61 2221882_149_317 at #355: S61 S 2221882_149_317 at #385: N62 2221882_149_317 at #385: N62 N 2221882_149_317 at #386: S63 2221882_149_317 at #386: S63 S 2221882_149_317 at #387: G64 2221882_149_317 at #387: G64 G 2221882_149_317 at #388: I65 2221882_149_317 at #388: I65 I 2221882_149_317 at #389: G66 2221882_149_317 at #389: G66 G 2221882_149_317 at #390: L67 2221882_149_317 at #390: L67 L 2221882_149_317 at #391: R68 2221882_149_317 at #391: R68 R 2221882_149_317 at #392: G69 2221882_149_317 at #392: G69 G 2221882_149_317 at #393: R70 2221882_149_317 at #393: R70 R 2221882_149_317 at #423 2221882_149_317 at #423 - 2221882_149_317 at #424 2221882_149_317 at #424 - 2221882_149_317 at #425 2221882_149_317 at #425 - 2221882_149_317 at #426 2221882_149_317 at #426 - 2221882_149_317 at #430 2221882_149_317 at #430 - 2221882_149_317 at #431 2221882_149_317 at #431 - 2221882_149_317 at #432 2221882_149_317 at #432 - 2221882_149_317 at #433 2221882_149_317 at #433 - 2221882_149_317 at #434 2221882_149_317 at #434 - 2221882_149_317 at #435 2221882_149_317 at #435 - 2221882_149_317 at #436: Y71 2221882_149_317 at #436: Y71 Y 2221882_149_317 at #438: E72 2221882_149_317 at #438: E72 E 2221882_149_317 at #439: I73 2221882_149_317 at #439: I73 I 2221882_149_317 at #440: Q74 2221882_149_317 at #440: Q74 Q 2221882_149_317 at #441: I75 2221882_149_317 at #441: I75 I 2221882_149_317 at #442: L76 2221882_149_317 at #442: L76 L 2221882_149_317 at #443: E77 2221882_149_317 at #443: E77 E 2221882_149_317 at #450: D78 2221882_149_317 at #450: D78 D 2221882_149_317 at #451: F79 2221882_149_317 at #451: F79 F 2221882_149_317 at #452: G80 2221882_149_317 at #452: G80 G 2221882_149_317 at #453: K81 2221882_149_317 at #453: K81 K 2221882_149_317 at #475: P82 2221882_149_317 at #475: P82 P 2221882_149_317 at #476: P83 2221882_149_317 at #476: P83 P 2221882_149_317 at #477: N84 2221882_149_317 at #477: N84 N 2221882_149_317 at #478: S85 2221882_149_317 at #478: S85 S 2221882_149_317 at #479: H86 2221882_149_317 at #479: H86 H 2221882_149_317 at #480: G87 2221882_149_317 at #480: G87 G 2221882_149_317 at #481: A88 2221882_149_317 at #481: A88 A 2221882_149_317 at #482: A89 2221882_149_317 at #482: A89 A 2221882_149_317 at #483: A90 2221882_149_317 at #483: A90 A 2221882_149_317 at #484: L91 2221882_149_317 at #484: L91 L 2221882_149_317 at #485: Y92 2221882_149_317 at #485: Y92 Y 2221882_149_317 at #486 2221882_149_317 at #486 - 2221882_149_317 at #487 2221882_149_317 at #487 - 2221882_149_317 at #530 2221882_149_317 at #530 - 2221882_149_317 at #532: S93 2221882_149_317 at #532: S93 S 2221882_149_317 at #533: R94 2221882_149_317 at #533: R94 R 2221882_149_317 at #534: V95 2221882_149_317 at #534: V95 V 2221882_149_317 at #535: P96 2221882_149_317 at #535: P96 P 2221882_149_317 at #544: P97 2221882_149_317 at #544: P97 P 2221882_149_317 at #545: S98 2221882_149_317 at #545: S98 S 2221882_149_317 at #548: V99 2221882_149_317 at #548: V99 V 2221882_149_317 at #549: N100 2221882_149_317 at #549: N100 N 2221882_149_317 at #550: A101 2221882_149_317 at #550: A101 A 2221882_149_317 at #551: S102 2221882_149_317 at #551: S102 S 2221882_149_317 at #552: K103 2221882_149_317 at #552: K103 K 2221882_149_317 at #553: P104 2221882_149_317 at #553: P104 P 2221882_149_317 at #554: A105 2221882_149_317 at #554: A105 A 2221882_149_317 at #555: G106 2221882_149_317 at #555: G106 G 2221882_149_317 at #556: E107 2221882_149_317 at #556: E107 E 2221882_149_317 at #557: W108 2221882_149_317 at #557: W108 W 2221882_149_317 at #558: Q109 2221882_149_317 at #558: Q109 Q 2221882_149_317 at #559: S110 2221882_149_317 at #559: S110 S 2221882_149_317 at #560: Y111 2221882_149_317 at #560: Y111 Y 2221882_149_317 at #561: D112 2221882_149_317 at #561: D112 D 2221882_149_317 at #562: I113 2221882_149_317 at #562: I113 I 2221882_149_317 at #565: R114 2221882_149_317 at #565: R114 R 2221882_149_317 at #566: L115 2221882_149_317 at #566: L115 L 2221882_149_317 at #568: V116 2221882_149_317 at #568: V116 V 2221882_149_317 at #570: G117 2221882_149_317 at #570: G117 G 2221882_149_317 at #571: R118 2221882_149_317 at #571: R118 R 2221882_149_317 at #572: T119 2221882_149_317 at #572: T119 T 2221882_149_317 at #588: L120 2221882_149_317 at #588: L120 L 2221882_149_317 at #589: T121 2221882_149_317 at #589: T121 T 2221882_149_317 at #592: V122 2221882_149_317 at #592: V122 V 2221882_149_317 at #594: V123 2221882_149_317 at #594: V123 V 2221882_149_317 at #595: H124 2221882_149_317 at #595: H124 H 2221882_149_317 at #596: N125 2221882_149_317 at #596: N125 N 2221882_149_317 at #598: G126 2221882_149_317 at #598: G126 G 2221882_149_317 at #599: T127 2221882_149_317 at #599: T127 T 2221882_149_317 at #600: K128 2221882_149_317 at #600: K128 K 2221882_149_317 at #601: V129 2221882_149_317 at #601: V129 V 2221882_149_317 at #602: L130 2221882_149_317 at #602: L130 L 2221882_149_317 at #603: D131 2221882_149_317 at #603: D131 D 2221882_149_317 at #604: R132 2221882_149_317 at #604: R132 R 2221882_149_317 at #605: V133 2221882_149_317 at #605: V133 V 2221882_149_317 at #606: E134 2221882_149_317 at #606: E134 E 2221882_149_317 at #607: V135 2221882_149_317 at #607: V135 V 2221882_149_317 at #608: E136 2221882_149_317 at #608: E136 E 2221882_149_317 at #609: G137 2221882_149_317 at #609: G137 G 2221882_149_317 at #610: L138 2221882_149_317 at #610: L138 L 2221882_149_317 at #611: T139 2221882_149_317 at #611: T139 T 2221882_149_317 at #612: A140 2221882_149_317 at #612: A140 A 2221882_149_317 at #613: I141 2221882_149_317 at #613: I141 I 2221882_149_317 at #614: A142 2221882_149_317 at #614: A142 A 2221882_149_317 at #615: N143 2221882_149_317 at #615: N143 N 2221882_149_317 at #616: N144 2221882_149_317 at #616: N144 N 2221882_149_317 at #640: D146 2221882_149_317 at #640: D146 D 2221882_149_317 at #641: E147 2221882_149_317 at #641: E147 E 2221882_149_317 at #642: A148 2221882_149_317 at #642: A148 A 2221882_149_317 at #643: E149 2221882_149_317 at #643: E149 E 2221882_149_317 at #644: P150 2221882_149_317 at #644: P150 P 2221882_149_317 at #645: G151 2221882_149_317 at #645: G151 G 2221882_149_317 at #646: P152 2221882_149_317 at #646: P152 P 2221882_149_317 at #647: F153 2221882_149_317 at #647: F153 F 2221882_149_317 at #648: I154 2221882_149_317 at #648: I154 I 2221882_149_317 at #649: V155 2221882_149_317 at #649: V155 V 2221882_149_317 at #650: Q156 2221882_149_317 at #650: Q156 Q 2221882_149_317 at #653: D158 2221882_149_317 at #653: D158 D 2221882_149_317 at #654: H159 2221882_149_317 at #654: H159 H 2221882_149_317 at #655: S160 2221882_149_317 at #655: S160 S 2221882_149_317 at #668 2221882_149_317 at #668 - 2221882_149_317 at #689: Y161 2221882_149_317 at #689: Y161 Y 2221882_149_317 at #690: V162 2221882_149_317 at #690: V162 V 2221882_149_317 at #691: E163 2221882_149_317 at #691: E163 E 2221882_149_317 at #694: I164 2221882_149_317 at #694: I164 I 2221882_149_317 at #695: R165 2221882_149_317 at #695: R165 R 2221882_149_317 at #696: K166 2221882_149_317 at #696: K166 K 2221882_149_317 at #697: F167 2221882_149_317 at #697: F167 F 2221882_149_317 at #698: T168 2221882_149_317 at #698: T168 T 2221882_149_317 at #699 2221882_149_317 at #699 - 2221882_149_317 at #700 2221882_149_317 at #700 - single domain, from Verrucomicrobium spinosum DSM 4136 6000697_153_324 single domain, from Verrucomicrobium spinosum DSM 4136 6000697_153_324 at #155 6000697_153_324 at #155 - 6000697_153_324 at #156 6000697_153_324 at #156 - 6000697_153_324 at #157 6000697_153_324 at #157 - 6000697_153_324 at #158: T2 6000697_153_324 at #158: T2 T 6000697_153_324 at #159: I3 6000697_153_324 at #159: I3 I 6000697_153_324 at #160: F4 6000697_153_324 at #160: F4 F 6000697_153_324 at #162: N5 6000697_153_324 at #162: N5 N 6000697_153_324 at #164: G6 6000697_153_324 at #164: G6 G 6000697_153_324 at #165: K7 6000697_153_324 at #165: K7 K 6000697_153_324 at #168: D8 6000697_153_324 at #168: D8 D 6000697_153_324 at #169: L9 6000697_153_324 at #169: L9 L 6000697_153_324 at #171: S10 6000697_153_324 at #171: S10 S 6000697_153_324 at #172: G11 6000697_153_324 at #172: G11 G 6000697_153_324 at #180: W12 6000697_153_324 at #180: W12 W 6000697_153_324 at #181: T13 6000697_153_324 at #181: T13 T 6000697_153_324 at #185: L14 6000697_153_324 at #185: L14 L 6000697_153_324 at #186: M15 6000697_153_324 at #186: M15 M 6000697_153_324 at #187: N16 6000697_153_324 at #187: N16 N 6000697_153_324 at #188: P17 6000697_153_324 at #188: P17 P 6000697_153_324 at #189: Q18 6000697_153_324 at #189: Q18 Q 6000697_153_324 at #190: S19 6000697_153_324 at #190: S19 S 6000697_153_324 at #191 6000697_153_324 at #191 - 6000697_153_324 at #195: D20 6000697_153_324 at #195: D20 D 6000697_153_324 at #196: N21 6000697_153_324 at #196: N21 N 6000697_153_324 at #197: G22 6000697_153_324 at #197: G22 G 6000697_153_324 at #198: W23 6000697_153_324 at #198: W23 W 6000697_153_324 at #235: S24 6000697_153_324 at #235: S24 S 6000697_153_324 at #236: V25 6000697_153_324 at #236: V25 V 6000697_153_324 at #237: V26 6000697_153_324 at #237: V26 V 6000697_153_324 at #238: D27 6000697_153_324 at #238: D27 D 6000697_153_324 at #240: G28 6000697_153_324 at #240: G28 G 6000697_153_324 at #268: V29 6000697_153_324 at #268: V29 V 6000697_153_324 at #269: L30 6000697_153_324 at #269: L30 L 6000697_153_324 at #270: Q31 6000697_153_324 at #270: Q31 Q 6000697_153_324 at #294: V34 6000697_153_324 at #294: V34 V 6000697_153_324 at #295: E35 6000697_153_324 at #295: E35 E 6000697_153_324 at #296: K36 6000697_153_324 at #296: K36 K 6000697_153_324 at #297: G37 6000697_153_324 at #297: G37 G 6000697_153_324 at #298: K38 6000697_153_324 at #298: K38 K 6000697_153_324 at #299: H39 6000697_153_324 at #299: H39 H 6000697_153_324 at #300: H40 6000697_153_324 at #300: H40 H 6000697_153_324 at #301: G41 6000697_153_324 at #301: G41 G 6000697_153_324 at #303: N42 6000697_153_324 at #303: N42 N 6000697_153_324 at #304: I43 6000697_153_324 at #304: I43 I 6000697_153_324 at #305: R44 6000697_153_324 at #305: R44 R 6000697_153_324 at #306: T45 6000697_153_324 at #306: T45 T 6000697_153_324 at #312: D46 6000697_153_324 at #312: D46 D 6000697_153_324 at #318: K47 6000697_153_324 at #318: K47 K 6000697_153_324 at #321: E48 6000697_153_324 at #321: E48 E 6000697_153_324 at #322: F49 6000697_153_324 at #322: F49 F 6000697_153_324 at #324: E50 6000697_153_324 at #324: E50 E 6000697_153_324 at #326: D51 6000697_153_324 at #326: D51 D 6000697_153_324 at #327: F52 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6000697_153_324 at #700 - download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory