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Showing 186 alignment positions (of 716) that are less than half gaps or lower-case

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Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

0.758 2223539_22_227: single domain, from Solibacter usitatus Ellin6076 0.806 4614159_234_440: tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4908012_29_247: single domain, from Gemmata obscuriglobus UQM 2246 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY Alignment position 560#560 Alignment position 385#385 Alignment position 566#566 Alignment position 387#387 Alignment position 332#332 Alignment position 561#561 Alignment position 533#533 Alignment position 330#330 Alignment position 600#600 Alignment position 610#610 Alignment position 588#588 Alignment position 668#668 Alignment position 191#191 Alignment position 162#162 Alignment position 438#438 Alignment position 299#299 Alignment position 195#195 Alignment position 425#425 Alignment position 535#535 Alignment position 452#452 Alignment position 602#602 Alignment position 164#164 Alignment position 552#552 Alignment position 530#530 Alignment position 612#612 Alignment position 558#558 Alignment position 698#698 Alignment position 696#696 Alignment position 476#476 Alignment position 442#442 Alignment position 435#435 Alignment position 295#295 Alignment position 158#158 Alignment position 326#326 Alignment position 351#351 Alignment position 198#198 Alignment position 443#443 Alignment position 430#430 Alignment position 650#650 Alignment position 607#607 Alignment position 432#432 Alignment position 690#690 Alignment position 649#649 Alignment position 643#643 Alignment position 433#433 Alignment position 322#322 Alignment position 312#312 Alignment position 572#572 Alignment position 390#390 Alignment position 436#436 Alignment position 328#328 Alignment position 549#549 Alignment position 321#321 Alignment position 187#187 Alignment position 334#334 Alignment position 237#237 Alignment position 324#324 Alignment position 532#532 Alignment position 169#169 Alignment position 269#269 Alignment position 185#185 Alignment position 188#188 Alignment position 614#614 Alignment position 589#589 Alignment position 647#647 Alignment position 386#386 Alignment position 235#235 Alignment position 595#595 Alignment position 640#640 Alignment position 155#155 Alignment position 389#389 Alignment position 654#654 Alignment position 554#554 Alignment position 480#480 Alignment position 160#160 Alignment position 487#487 Alignment position 327#327 Alignment position 562#562 Alignment position 570#570 Alignment position 556#556 Alignment position 484#484 Alignment position 699#699 Alignment position 486#486 Alignment position 196#196 Alignment position 644#644 Alignment position 171#171 Alignment position 392#392 Alignment position 555#555 Alignment position 601#601 Alignment position 553#553 Alignment position 181#181 Alignment position 599#599 Alignment position 180#180 Alignment position 697#697 Alignment position 434#434 Alignment position 352#352 Alignment position 648#648 Alignment position 298#298 Alignment position 596#596 Alignment position 335#335 Alignment position 534#534 Alignment position 441#441 Alignment position 691#691 Alignment position 300#300 Alignment position 605#605 Alignment position 431#431 Alignment position 603#603 Alignment position 557#557 Alignment position 478#478 Alignment position 424#424 Alignment position 551#551 Alignment position 190#190 Alignment position 613#613 Alignment position 331#331 Alignment position 453#453 Alignment position 296#296 Alignment position 168#168 Alignment position 481#481 Alignment position 439#439 Alignment position 611#611 Alignment position 475#475 Alignment position 482#482 Alignment position 423#423 Alignment position 616#616 Alignment position 565#565 Alignment position 305#305 Alignment position 477#477 Alignment position 548#548 Alignment position 559#559 Alignment position 689#689 Alignment position 483#483 Alignment position 303#303 Alignment position 450#450 Alignment position 294#294 Alignment position 238#238 Alignment position 694#694 Alignment position 550#550 Alignment position 594#594 Alignment position 189#189 Alignment position 646#646 Alignment position 568#568 Alignment position 354#354 Alignment position 642#642 Alignment position 655#655 Alignment position 571#571 Alignment position 301#301 Alignment position 641#641 Alignment position 157#157 Alignment position 304#304 Alignment position 485#485 Alignment position 306#306 Alignment position 615#615 Alignment position 700#700 Alignment position 393#393 Alignment position 451#451 Alignment position 545#545 Alignment position 606#606 Alignment position 156#156 Alignment position 388#388 Alignment position 329#329 Alignment position 240#240 Alignment position 608#608 Alignment position 268#268 Alignment position 544#544 Alignment position 270#270 Alignment position 159#159 Alignment position 645#645 Alignment position 355#355 Alignment position 236#236 Alignment position 695#695 Alignment position 186#186 Alignment position 598#598 Alignment position 333#333 Alignment position 391#391 Alignment position 426#426 Alignment position 592#592 Alignment position 440#440 Alignment position 653#653 Alignment position 318#318 Alignment position 297#297 Alignment position 609#609 Alignment position 165#165 Alignment position 197#197 Alignment position 604#604 Alignment position 172#172 Alignment position 479#479 single domain, from Solibacter usitatus Ellin6076 2223539_22_227 single domain, from Solibacter usitatus Ellin6076 2223539_22_227 at #155: G1 2223539_22_227 at #155: G1 G 2223539_22_227 at #156: Y2 2223539_22_227 at #156: Y2 Y 2223539_22_227 at #157: T3 2223539_22_227 at #157: T3 T 2223539_22_227 at #158: A4 2223539_22_227 at #158: A4 A 2223539_22_227 at #159: L5 2223539_22_227 at #159: L5 L 2223539_22_227 at #160: F6 2223539_22_227 at #160: F6 F 2223539_22_227 at #162: N7 2223539_22_227 at #162: N7 N 2223539_22_227 at #164: G8 2223539_22_227 at #164: G8 G 2223539_22_227 at #165: K9 2223539_22_227 at #165: K9 K 2223539_22_227 at #168: D10 2223539_22_227 at #168: D10 D 2223539_22_227 at #169: L11 2223539_22_227 at #169: L11 L 2223539_22_227 at #171: S12 2223539_22_227 at #171: S12 S 2223539_22_227 at #172: G13 2223539_22_227 at #172: G13 G 2223539_22_227 at #180: W14 2223539_22_227 at #180: W14 W 2223539_22_227 at #181: R15 2223539_22_227 at #181: R15 R 2223539_22_227 at #185: G16 2223539_22_227 at #185: G16 G 2223539_22_227 at #186: R17 2223539_22_227 at #186: R17 R 2223539_22_227 at #187: Q18 2223539_22_227 at #187: Q18 Q 2223539_22_227 at #188: G19 2223539_22_227 at #188: G19 G 2223539_22_227 at #189: T20 2223539_22_227 at #189: T20 T 2223539_22_227 at #190: Y21 2223539_22_227 at #190: Y21 Y 2223539_22_227 at #191: S22 2223539_22_227 at #191: S22 S 2223539_22_227 at #195: P23 2223539_22_227 at #195: P23 P 2223539_22_227 at #196: H24 2223539_22_227 at #196: H24 H 2223539_22_227 at #197: A25 2223539_22_227 at #197: A25 A 2223539_22_227 at #198: E26 2223539_22_227 at #198: E26 E 2223539_22_227 at #235: D52 2223539_22_227 at #235: D52 D 2223539_22_227 at #236: V53 2223539_22_227 at #236: V53 V 2223539_22_227 at #237: A54 2223539_22_227 at #237: A54 A 2223539_22_227 at #238: K55 2223539_22_227 at #238: K55 K 2223539_22_227 at #240: G56 2223539_22_227 at #240: G56 G 2223539_22_227 at #268: E57 2223539_22_227 at #268: E57 E 2223539_22_227 at #269: I58 2223539_22_227 at #269: I58 I 2223539_22_227 at #270: V59 2223539_22_227 at #270: V59 V 2223539_22_227 at #294 2223539_22_227 at #294 - 2223539_22_227 at #295 2223539_22_227 at #295 - 2223539_22_227 at #296: S60 2223539_22_227 at #296: S60 S 2223539_22_227 at #297: D61 2223539_22_227 at #297: D61 D 2223539_22_227 at #298: G62 2223539_22_227 at #298: G62 G 2223539_22_227 at #299: K63 2223539_22_227 at #299: K63 K 2223539_22_227 at #300: S64 2223539_22_227 at #300: S64 S 2223539_22_227 at #301: V65 2223539_22_227 at #301: V65 V 2223539_22_227 at #303: H66 2223539_22_227 at #303: H66 H 2223539_22_227 at #304: L67 2223539_22_227 at #304: L67 L 2223539_22_227 at #305: A68 2223539_22_227 at #305: A68 A 2223539_22_227 at #306: T69 2223539_22_227 at #306: T69 T 2223539_22_227 at #312: A70 2223539_22_227 at #312: A70 A 2223539_22_227 at #318: R71 2223539_22_227 at #318: R71 R 2223539_22_227 at #321: D72 2223539_22_227 at #321: D72 D 2223539_22_227 at #322: Y73 2223539_22_227 at #322: Y73 Y 2223539_22_227 at #324: R74 2223539_22_227 at #324: R74 R 2223539_22_227 at #326: D75 2223539_22_227 at #326: D75 D 2223539_22_227 at #327: F76 2223539_22_227 at #327: F76 F 2223539_22_227 at #328: D77 2223539_22_227 at #328: D77 D 2223539_22_227 at #329: L78 2223539_22_227 at #329: L78 L 2223539_22_227 at #330: Y79 2223539_22_227 at #330: Y79 Y 2223539_22_227 at #331: V80 2223539_22_227 at #331: V80 V 2223539_22_227 at #332: D81 2223539_22_227 at #332: D81 D 2223539_22_227 at #333: W82 2223539_22_227 at #333: W82 W 2223539_22_227 at #334: L83 2223539_22_227 at #334: L83 L 2223539_22_227 at #335: M84 2223539_22_227 at #335: M84 M 2223539_22_227 at #351: V85 2223539_22_227 at #351: V85 V 2223539_22_227 at #352: K86 2223539_22_227 at #352: K86 K 2223539_22_227 at #354: N88 2223539_22_227 at #354: N88 N 2223539_22_227 at #355: G89 2223539_22_227 at #355: G89 G 2223539_22_227 at #385: D90 2223539_22_227 at #385: D90 D 2223539_22_227 at #386: S91 2223539_22_227 at #386: S91 S 2223539_22_227 at #387: G92 2223539_22_227 at #387: G92 G 2223539_22_227 at #388: I93 2223539_22_227 at #388: I93 I 2223539_22_227 at #389: Y94 2223539_22_227 at #389: Y94 Y 2223539_22_227 at #390: L95 2223539_22_227 at #390: L95 L 2223539_22_227 at #391: R96 2223539_22_227 at #391: R96 R 2223539_22_227 at #392: S97 2223539_22_227 at #392: S97 S 2223539_22_227 at #393: Y98 2223539_22_227 at #393: Y98 Y 2223539_22_227 at #423 2223539_22_227 at #423 - 2223539_22_227 at #424 2223539_22_227 at #424 - 2223539_22_227 at #425 2223539_22_227 at #425 - 2223539_22_227 at #426 2223539_22_227 at #426 - 2223539_22_227 at #430 2223539_22_227 at #430 - 2223539_22_227 at #431 2223539_22_227 at #431 - 2223539_22_227 at #432 2223539_22_227 at #432 - 2223539_22_227 at #433 2223539_22_227 at #433 - 2223539_22_227 at #434 2223539_22_227 at #434 - 2223539_22_227 at #435 2223539_22_227 at #435 - 2223539_22_227 at #436: P99 2223539_22_227 at #436: P99 P 2223539_22_227 at #438: Q100 2223539_22_227 at #438: Q100 Q 2223539_22_227 at #439: V101 2223539_22_227 at #439: V101 V 2223539_22_227 at #440: Q102 2223539_22_227 at #440: Q102 Q 2223539_22_227 at #441: I103 2223539_22_227 at #441: I103 I 2223539_22_227 at #442: W104 2223539_22_227 at #442: W104 W 2223539_22_227 at #443: D105 2223539_22_227 at #443: D105 D 2223539_22_227 at #450: V106 2223539_22_227 at #450: V106 V 2223539_22_227 at #451: D107 2223539_22_227 at #451: D107 D 2223539_22_227 at #452: N108 2223539_22_227 at #452: N108 N 2223539_22_227 at #453: P109 2223539_22_227 at #453: P109 P 2223539_22_227 at #475: N114 2223539_22_227 at #475: N114 N 2223539_22_227 at #476: G115 2223539_22_227 at #476: G115 G 2223539_22_227 at #477: A116 2223539_22_227 at #477: A116 A 2223539_22_227 at #478: P117 2223539_22_227 at #478: P117 P 2223539_22_227 at #479: R118 2223539_22_227 at #479: R118 R 2223539_22_227 at #480: G119 2223539_22_227 at #480: G119 G 2223539_22_227 at #481: S120 2223539_22_227 at #481: S120 S 2223539_22_227 at #482: G121 2223539_22_227 at #482: G121 G 2223539_22_227 at #483: A122 2223539_22_227 at #483: A122 A 2223539_22_227 at #484: L123 2223539_22_227 at #484: L123 L 2223539_22_227 at #485: W124 2223539_22_227 at #485: W124 W 2223539_22_227 at #486: N125 2223539_22_227 at #486: N125 N 2223539_22_227 at #487: N126 2223539_22_227 at #487: N126 N 2223539_22_227 at #530: N127 2223539_22_227 at #530: N127 N 2223539_22_227 at #532 2223539_22_227 at #532 - 2223539_22_227 at #533 2223539_22_227 at #533 - 2223539_22_227 at #534: D129 2223539_22_227 at #534: D129 D 2223539_22_227 at #535: N130 2223539_22_227 at #535: N130 N 2223539_22_227 at #544: P135 2223539_22_227 at #544: P135 P 2223539_22_227 at #545: L136 2223539_22_227 at #545: L136 L 2223539_22_227 at #548: V137 2223539_22_227 at #548: V137 V 2223539_22_227 at #549: K138 2223539_22_227 at #549: K138 K 2223539_22_227 at #550: A139 2223539_22_227 at #550: A139 A 2223539_22_227 at #551: D140 2223539_22_227 at #551: D140 D 2223539_22_227 at #552: N141 2223539_22_227 at #552: N141 N 2223539_22_227 at #553: P142 2223539_22_227 at #553: P142 P 2223539_22_227 at #554: V143 2223539_22_227 at #554: V143 V 2223539_22_227 at #555: G144 2223539_22_227 at #555: G144 G 2223539_22_227 at #556: A145 2223539_22_227 at #556: A145 A 2223539_22_227 at #557: W146 2223539_22_227 at #557: W146 W 2223539_22_227 at #558: N147 2223539_22_227 at #558: N147 N 2223539_22_227 at #559: T148 2223539_22_227 at #559: T148 T 2223539_22_227 at #560: F149 2223539_22_227 at #560: F149 F 2223539_22_227 at #561: R150 2223539_22_227 at #561: R150 R 2223539_22_227 at #562: I151 2223539_22_227 at #562: I151 I 2223539_22_227 at #565: K152 2223539_22_227 at #565: K152 K 2223539_22_227 at #566: M153 2223539_22_227 at #566: M153 M 2223539_22_227 at #568: A154 2223539_22_227 at #568: A154 A 2223539_22_227 at #570: G155 2223539_22_227 at #570: G155 G 2223539_22_227 at #571: S156 2223539_22_227 at #571: S156 S 2223539_22_227 at #572: R157 2223539_22_227 at #572: R157 R 2223539_22_227 at #588: V158 2223539_22_227 at #588: V158 V 2223539_22_227 at #589: S159 2223539_22_227 at #589: S159 S 2223539_22_227 at #592: V160 2223539_22_227 at #592: V160 V 2223539_22_227 at #594: W161 2223539_22_227 at #594: W161 W 2223539_22_227 at #595: L162 2223539_22_227 at #595: L162 L 2223539_22_227 at #596: N163 2223539_22_227 at #596: N163 N 2223539_22_227 at #598: G164 2223539_22_227 at #598: G164 G 2223539_22_227 at #599: K165 2223539_22_227 at #599: K165 K 2223539_22_227 at #600: L166 2223539_22_227 at #600: L166 L 2223539_22_227 at #601: T167 2223539_22_227 at #601: T167 T 2223539_22_227 at #602: V168 2223539_22_227 at #602: V168 V 2223539_22_227 at #603: D169 2223539_22_227 at #603: D169 D 2223539_22_227 at #604: N170 2223539_22_227 at #604: N170 N 2223539_22_227 at #605: Q171 2223539_22_227 at #605: Q171 Q 2223539_22_227 at #606: V172 2223539_22_227 at #606: V172 V 2223539_22_227 at #607: L173 2223539_22_227 at #607: L173 L 2223539_22_227 at #608: D174 2223539_22_227 at #608: D174 D 2223539_22_227 at #609: N175 2223539_22_227 at #609: N175 N 2223539_22_227 at #610: F176 2223539_22_227 at #610: F176 F 2223539_22_227 at #611: Y177 2223539_22_227 at #611: Y177 Y 2223539_22_227 at #612: N178 2223539_22_227 at #612: N178 N 2223539_22_227 at #613: R179 2223539_22_227 at #613: R179 R 2223539_22_227 at #614: S180 2223539_22_227 at #614: S180 S 2223539_22_227 at #615: L181 2223539_22_227 at #615: L181 L 2223539_22_227 at #616: P182 2223539_22_227 at #616: P182 P 2223539_22_227 at #640 2223539_22_227 at #640 - 2223539_22_227 at #641: L183 2223539_22_227 at #641: L183 L 2223539_22_227 at #642: V184 2223539_22_227 at #642: V184 V 2223539_22_227 at #643: P185 2223539_22_227 at #643: P185 P 2223539_22_227 at #644: K186 2223539_22_227 at #644: K186 K 2223539_22_227 at #645: G187 2223539_22_227 at #645: G187 G 2223539_22_227 at #646: A188 2223539_22_227 at #646: A188 A 2223539_22_227 at #647: I189 2223539_22_227 at #647: I189 I 2223539_22_227 at #648: E190 2223539_22_227 at #648: E190 E 2223539_22_227 at #649: L191 2223539_22_227 at #649: L191 L 2223539_22_227 at #650: Q192 2223539_22_227 at #650: Q192 Q 2223539_22_227 at #653: T193 2223539_22_227 at #653: T193 T 2223539_22_227 at #654: H194 2223539_22_227 at #654: H194 H 2223539_22_227 at #655: G195 2223539_22_227 at #655: G195 G 2223539_22_227 at #668: S196 2223539_22_227 at #668: S196 S 2223539_22_227 at #689: E197 2223539_22_227 at #689: E197 E 2223539_22_227 at #690: I198 2223539_22_227 at #690: I198 I 2223539_22_227 at #691: R199 2223539_22_227 at #691: R199 R 2223539_22_227 at #694: F200 2223539_22_227 at #694: F200 F 2223539_22_227 at #695: R201 2223539_22_227 at #695: R201 R 2223539_22_227 at #696: N202 2223539_22_227 at #696: N202 N 2223539_22_227 at #697: I203 2223539_22_227 at #697: I203 I 2223539_22_227 at #698: Y204 2223539_22_227 at #698: Y204 Y 2223539_22_227 at #699: I205 2223539_22_227 at #699: I205 I 2223539_22_227 at #700: K206 2223539_22_227 at #700: K206 K tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_234_440 tandem domain, near sugar dehydrogenase, from Lentisphaera araneosa HTCC2155 4614159_234_440 at #155: G1 4614159_234_440 at #155: G1 G 4614159_234_440 at #156: F2 4614159_234_440 at #156: F2 F 4614159_234_440 at #157: T3 4614159_234_440 at #157: T3 T 4614159_234_440 at #158: Q4 4614159_234_440 at #158: Q4 Q 4614159_234_440 at #159: L5 4614159_234_440 at #159: L5 L 4614159_234_440 at #160: F6 4614159_234_440 at #160: F6 F 4614159_234_440 at #162: N7 4614159_234_440 at #162: N7 N 4614159_234_440 at #164: G8 4614159_234_440 at #164: G8 G 4614159_234_440 at #165: K9 4614159_234_440 at #165: K9 K 4614159_234_440 at #168: D10 4614159_234_440 at #168: D10 D 4614159_234_440 at #169: L11 4614159_234_440 at #169: L11 L 4614159_234_440 at #171: T12 4614159_234_440 at #171: T12 T 4614159_234_440 at #172: N13 4614159_234_440 at #172: N13 N 4614159_234_440 at #180: W14 4614159_234_440 at #180: W14 W 4614159_234_440 at #181: K15 4614159_234_440 at #181: K15 K 4614159_234_440 at #185: G16 4614159_234_440 at #185: G16 G 4614159_234_440 at #186: L17 4614159_234_440 at #186: L17 L 4614159_234_440 at #187: L18 4614159_234_440 at #187: L18 L 4614159_234_440 at #188: D19 4614159_234_440 at #188: D19 D 4614159_234_440 at #189: R20 4614159_234_440 at #189: R20 R 4614159_234_440 at #190: P21 4614159_234_440 at #190: P21 P 4614159_234_440 at #191: F22 4614159_234_440 at #191: F22 F 4614159_234_440 at #195: D23 4614159_234_440 at #195: D23 D 4614159_234_440 at #196: R24 4614159_234_440 at #196: R24 R 4614159_234_440 at #197: P25 4614159_234_440 at #197: P25 P 4614159_234_440 at #198: H26 4614159_234_440 at #198: H26 H 4614159_234_440 at #235: V53 4614159_234_440 at #235: V53 V 4614159_234_440 at #236: T54 4614159_234_440 at #236: T54 T 4614159_234_440 at #237: D55 4614159_234_440 at #237: D55 D 4614159_234_440 at #238: K56 4614159_234_440 at #238: K56 K 4614159_234_440 at #240: G57 4614159_234_440 at #240: G57 G 4614159_234_440 at #268: E58 4614159_234_440 at #268: E58 E 4614159_234_440 at #269: L59 4614159_234_440 at #269: L59 L 4614159_234_440 at #270: F60 4614159_234_440 at #270: F60 F 4614159_234_440 at #294: F61 4614159_234_440 at #294: F61 F 4614159_234_440 at #295: D62 4614159_234_440 at #295: D62 D 4614159_234_440 at #296: G63 4614159_234_440 at #296: G63 G 4614159_234_440 at #297: K64 4614159_234_440 at #297: K64 K 4614159_234_440 at #298: K65 4614159_234_440 at #298: K65 K 4614159_234_440 at #299: G66 4614159_234_440 at #299: G66 G 4614159_234_440 at #300: G67 4614159_234_440 at #300: G67 G 4614159_234_440 at #301: H68 4614159_234_440 at #301: H68 H 4614159_234_440 at #303: S69 4614159_234_440 at #303: S69 S 4614159_234_440 at #304: L70 4614159_234_440 at #304: L70 L 4614159_234_440 at #305: A71 4614159_234_440 at #305: A71 A 4614159_234_440 at #306: T72 4614159_234_440 at #306: T72 T 4614159_234_440 at #312: L73 4614159_234_440 at #312: L73 L 4614159_234_440 at #318: K74 4614159_234_440 at #318: K74 K 4614159_234_440 at #321: Q75 4614159_234_440 at #321: Q75 Q 4614159_234_440 at #322: Y76 4614159_234_440 at #322: Y76 Y 4614159_234_440 at #324: K77 4614159_234_440 at #324: K77 K 4614159_234_440 at #326: D78 4614159_234_440 at #326: D78 D 4614159_234_440 at #327: F79 4614159_234_440 at #327: F79 F 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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory