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Zoomed into a clade of 4 proteins, or see all 240 proteins. Position numbering is from BT2157.

Comment: DUF1080 is a family of hydrolases and includes putative 3-ketoglycoside hydrolases. The putative active site was identified from the structure of BT2157 (PDB:3osd). In the tree, BT2157 and other 3-ketoglycoside hydrolases are colored green, and endoglucanase THTE_1561 is in red. These members of DUF1080 were taken from MicrobesOnline (using hits to PFam PF06439.11 with 80 bits or higher), clustered at 60% identity to reduce the number of sequences, and aligned using hmmalign.

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Highlight proteins:

11261816_60_268: single domain, from Flexibacter tractuosus DSM 4126 (has NEQ) 3723687_51_268: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ) BT2157: single domain 3-ketoglycoside hydrolase from Bacteroides thetaiotaomicron VPI-5482 (has NEQ) 3722639_36_242: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ) BT2157 has N at position 134 (alignment position 385)N134 11261816_60_268 has N73 EQ 3723687_51_268 has N71 EQ BT2157 has N134 EQ 3722639_36_242 has N74 EQ 11261816_60_268 and 3 similar proteins have N aligning to 134N BT2157 has E at position 164 (alignment position 438)E164 11261816_60_268 has N E93 Q 3723687_51_268 has N E92 Q BT2157 has N E164 Q 3722639_36_242 has N E95 Q 11261816_60_268 and 3 similar proteins have E aligning to 164E BT2157 has Q at position 166 (alignment position 440)Q166 11261816_60_268 has NE Q95 3723687_51_268 has NE Q94 BT2157 has NE Q166 3722639_36_242 has NE Q97 11261816_60_268 and 3 similar proteins have Q aligning to 166Q 11261816_60_268: single domain, from Flexibacter tractuosus DSM 4126 11261816_60_26811261816_60_268: single domain, from Flexibacter tractuosus DSM 4126 0.355 0.972 3723687_51_268: single domain, from Parabacteroides distasonis ATCC 8503 3723687_51_2683723687_51_268: single domain, from Parabacteroides distasonis ATCC 8503 BT2157: single domain 3-ketoglycoside hydrolase from Bacteroides thetaiotaomicron VPI-5482 BT2157BT2157: single domain 3-ketoglycoside hydrolase from Bacteroides thetaiotaomicron VPI-5482 3722639_36_242: single domain, from Parabacteroides distasonis ATCC 8503 3722639_36_2423722639_36_242: single domain, from Parabacteroides distasonis ATCC 8503 11261816_60_268: single domain, from Flexibacter tractuosus DSM 4126 (has NEQ)11261816_60_268 single domain, from Flexibacter tractuosus DSM 4126 3723687_51_268: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ)3723687_51_268 single domain, from Parabacteroides distasonis ATCC 8503 BT2157: single domain 3-ketoglycoside hydrolase from Bacteroides thetaiotaomicron VPI-5482 (has NEQ)BT2157 single domain 3-ketoglycoside hydrolase from Bacteroides thetaiotaomicron VPI-5482 3722639_36_242: single domain, from Parabacteroides distasonis ATCC 8503 (has NEQ)3722639_36_242 single domain, from Parabacteroides distasonis ATCC 8503 0.5 /site amino acids:gapgap-alaninealanineAcysteinecysteineCaspartateaspartateDglutamateglutamateEphenylalaninephenylalanineFglycineglycineGhistidinehistidineHisoleucineisoleucineIlysinelysineKleucineleucineLmethioninemethionineMasparagineasparagineNprolineprolinePglutamineglutamineQargininearginineRserineserineSthreoninethreonineTvalinevalineVtryptophantryptophanWtyrosinetyrosineY download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory