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Searching for up to 100 curated homologs for 14148 FitnessBrowser__Keio:14148 (310 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

Removed hits that are identical to the query, leaving 29

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

thrB / CAA43213.1 homoserine kinase from Serratia marcescens (see paper)
    80% identity, 99% coverage of query (524 bits)

Echvi_2001 homoserine kinase (EC 2.7.1.39) from Echinicola vietnamensis KMM 6221, DSM 17526
    37% identity, 90% coverage of query (141 bits)

CA265_RS23470 homoserine kinase (EC 2.7.1.39) from Pedobacter sp. GW460-11-11-14-LB5
    35% identity, 90% coverage of query (140 bits)

hsk / Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana (see paper)
KHSE_ARATH / Q8L7R2 Homoserine kinase; Protein DOWNY MILDEW RESISTANT 1; EC 2.7.1.39 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q8L7R2 homoserine kinase (EC 2.7.1.39) from Arabidopsis thaliana (see 4 papers)
    32% identity, 100% coverage of query (106 bits)

thrB / Q58504 homoserine kinase monomer (EC 2.7.1.39) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
1fwkA / Q58504 Crystal structure of homoserine kinase complexed with adp (see paper)
    31% identity, 93% coverage of query (105 bits)

1h74B Crystal structure of homoserine kinase complexed with ile
    31% identity, 93% coverage of query (105 bits)

1h74A Crystal structure of homoserine kinase complexed with ile
    31% identity, 93% coverage of query (105 bits)

1h73A Crystal structure of homoserine kinase complexed with threonine
    31% identity, 93% coverage of query (105 bits)

1h72C Crystal structure of homoserine kinase complexed with hse
    31% identity, 93% coverage of query (105 bits)

N515DRAFT_0576 homoserine kinase (EC 2.7.1.39) from Dyella japonica UNC79MFTsu3.2
    33% identity, 85% coverage of query (96.7 bits)

KHSE_METMP / Q6M0H5 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Methanococcus maripaludis (strain S2 / LL) (see paper)
    30% identity, 87% coverage of query (92.4 bits)

Build an alignment

Build an alignment for 14148 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

Q4Q6Y2 homoserine kinase (EC 2.7.1.39) from Leishmania major (see paper)
    28% identity, 86% coverage of query (79.7 bits)

KHSE_YEAST / P17423 Homoserine kinase; HK; HSK; EC 2.7.1.39 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
THR1 / AAA35154.1 homoserine kinase from Saccharomyces cerevisiae (see paper)
    23% identity, 93% coverage of query (73.9 bits)

4dxlA / B1MKD5 Crystal structure of ispe (4-diphosphocytidyl-2-c-methyl-d-erythritol kinase) from mycobacterium abscessus, bound to cmp and atp (see paper)
    26% identity, 80% coverage of query (69.7 bits)

ISPE_MYCTU / P9WKG7 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase; EC 2.7.1.148 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WKG7 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) from Mycobacterium tuberculosis (see paper)
    26% identity, 89% coverage of query (67.8 bits)

3pyeA / P9WKG7 Mycobacterium tuberculosis 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase (ispe) in complex with cdpme
    26% identity, 90% coverage of query (67.8 bits)

3pygA Mycobacterium tuberculosis 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase (ispe) in complex with adp
    26% identity, 90% coverage of query (67.8 bits)

3pyfA Mycobacterium tuberculosis 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase (ispe) in complex with amp-pnp
    26% identity, 89% coverage of query (67.8 bits)

P07128 homoserine kinase (EC 2.7.1.39) from Corynebacterium glutamicum (see paper)
    26% identity, 98% coverage of query (60.8 bits)

O67060 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) from Aquifex aeolicus (see paper)
    25% identity, 74% coverage of query (54.7 bits)

2v2qB / O67060 Ispe in complex with ligand (see paper)
    25% identity, 74% coverage of query (54.7 bits)

2v8pA Ispe in complex with adp and cdp
    25% identity, 74% coverage of query (54.7 bits)

2v34B Ispe in complex with cytidine and ligand
    25% identity, 74% coverage of query (54.7 bits)

2v2vA Ispe in complex with ligand
    25% identity, 74% coverage of query (54.7 bits)

2vf3A Aquifex aeolicus ispe in complex with ligand
    25% identity, 74% coverage of query (54.3 bits)

2v34A Ispe in complex with cytidine and ligand
    25% identity, 74% coverage of query (54.3 bits)

2v2zA Ispe in complex with adp and cdpme
    25% identity, 74% coverage of query (54.3 bits)

P37550 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC 2.7.1.148) from Bacillus subtilis (see paper)
    25% identity, 80% coverage of query (53.5 bits)

6cyzA / B1MLU6 Mycobacterial homoserine kinase thrb in complex with amppnp
    29% identity, 91% coverage of query (51.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory