Searching for up to 100 curated homologs for 14218 b0072 isopropylmalate isomerase large subunit (NCBI) (466 a.a.)
Found high-coverage hits (≥70%) to 61 curated proteins.
Removed hits that are identical to the query, leaving 60
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
LEUC1_SALTY / P15717 3-isopropylmalate dehydratase large subunit 1; Alpha-IPM isomerase 1; IPMI 1; Isopropylmalate isomerase 1; EC 4.2.1.33 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
95% identity, 100% coverage of query (905 bits)
leuC / Q8F4E6 isopropylmalate isomerase large subunit (EC 4.2.1.35) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see paper)
66% identity, 100% coverage of query (651 bits)
leu1 / CAB99455.1 3-isopropylmalate dehydratase, partial from Yarrowia lipolytica (see paper)
63% identity, 100% coverage of query (610 bits)
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
64% identity, 99% coverage of query (595 bits)
LEUC_YEAST / P07264 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
61% identity, 100% coverage of query (588 bits)
LEUC_MYCBO / Q7TXH6 3-isopropylmalate dehydratase large subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) (see paper)
61% identity, 98% coverage of query (578 bits)
P9WQF5 3-isopropylmalate dehydratase (EC 4.2.1.33) from Mycobacterium tuberculosis (see paper)
61% identity, 98% coverage of query (576 bits)
AN5886 alpha isopropylmalate isomerase (Eurofung) from Emericella nidulans (see paper)
60% identity, 99% coverage of query (574 bits)
LEUC_CORGL / P58946 3-isopropylmalate dehydratase large subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
60% identity, 99% coverage of query (574 bits)
hacA / Q58409 homoaconitase α subunit (EC 4.2.1.36) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
HACA_METJA / Q58409 Methanogen homoaconitase large subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 3 papers)
Q58409 methanogen homoaconitase (EC 4.2.1.114) from Methanocaldococcus jannaschii (see paper)
hacA homoaconitase; EC 4.2.1.-; EC 4.2.1.36 from Methanocaldococcus jannaschii (see 3 papers)
34% identity, 98% coverage of query (240 bits)
leuC / P81291 isopropylmalate isomerase large subunit (EC 4.2.1.35) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
LEUC_METJA / P81291 Isopropylmalate/citramalate isomerase large subunit; (R)-2-methylmalate dehydratase; (R)-citramalate dehydratase; 3-isopropylmalate dehydratase; Alpha-isopropylmalate dehydratase; Citraconate hydratase; Isopropylmalate isomerase; IPMI; Maleate hydratase; Malease; EC 4.2.1.33; EC 4.2.1.35; EC 4.2.1.31 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
P81291 3-isopropylmalate dehydratase (EC 4.2.1.33); homoaconitate hydratase (EC 4.2.1.36) from Methanocaldococcus jannaschii (see paper)
37% identity, 94% coverage of query (239 bits)
4kp1A / P81291 Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) (see paper)
37% identity, 94% coverage of query (239 bits)
4nqyA The reduced form of mj0499
36% identity, 94% coverage of query (232 bits)
hphCD / B2J8P2 benzylmalate isomerase from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see paper)
33% identity, 98% coverage of query (221 bits)
IPMI1 / Q94AR8 isopropylmalate isomerase large subunit (EC 4.2.1.33) from Arabidopsis thaliana (see paper)
LEUC_ARATH / Q94AR8 3-isopropylmalate dehydratase large subunit, chloroplastic; 2-(omega-methylthio)alkylmalate dehydratase large subunit; AtLEUC; Isopropylmalate isomerase large subunit 1; AtIIL1; IPMI LSU1; Methylthioalkylmalate isomerase large subunit; MAM-IL; EC 4.2.1.33; EC 4.2.1.170 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q94AR8 2-(omega-methylthio)alkylmalate dehydratase (subunit 2/2) (EC 4.2.1.170); 3-isopropylmalate dehydratase (EC 4.2.1.33) from Arabidopsis thaliana (see paper)
34% identity, 94% coverage of query (204 bits)
DVU2982 3-isopropylmalate dehydratase / (R)-citramalate isomerase, large subunit LeuC (EC 4.2.1.33; EC 4.2.1.35) from Desulfovibrio vulgaris Hildenborough JW710
33% identity, 99% coverage of query (199 bits)
Build an alignment for 14218 and 16 homologs with ≥ 30% identity
Or download the sequences
dmdA / Q0QLE2 dimethylmaleate hydratase subunit A (EC 4.2.1.85) from Eubacterium barkeri (see paper)
DMDA_EUBBA / Q0QLE2 2,3-dimethylmalate dehydratase large subunit; EC 4.2.1.85 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
29% identity, 99% coverage of query (184 bits)
lysT / Q9ZNE0 homoaconitase large subunit (EC 4.2.1.36) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 3 papers)
HACA_THET2 / Q9ZNE0 Homoaconitase large subunit; HACN; Homoaconitate hydratase; EC 4.2.1.36 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
32% identity, 88% coverage of query (180 bits)
HtyD / K0E2G4 2-(4-hydroxybenzyl)-malate isomerase from Aspergillus rugulosus (see paper)
HTYD_ASPRU / K0E2G4 Aconitase htyD; L-homotyrosine biosynthetic cluster protein D; EC 4.2.1.- from Aspergillus rugulosus (Emericella rugulosa) (see paper)
30% identity, 74% coverage of query (160 bits)
LYS4_EMENI / Q92412 Homoaconitase, mitochondrial; Homoaconitate hydratase; EC 4.2.1.36 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
Q92412 homoaconitate hydratase (EC 4.2.1.36) from Aspergillus nidulans (see paper)
27% identity, 93% coverage of query (154 bits)
J9VIU5 methanogen homoaconitase (EC 4.2.1.114) from Cryptococcus neoformans var. grubii serotype A (see paper)
26% identity, 93% coverage of query (152 bits)
lysF / GI|1628374 homoaconitase, mitochondrial; EC 4.2.1.36 from Emericella nidulans (see paper)
27% identity, 93% coverage of query (151 bits)
GLOJ_GLAL2 / S3E7P8 3-isopropylmalate dehydratase large subunit gloJ; L-homotyrosine biosynthesis sub-cluster protein gloJ; Pneumocandin biosynthesis cluster protein J; EC 4.2.1.33 from Glarea lozoyensis (strain ATCC 20868 / MF5171) (see 5 papers)
29% identity, 72% coverage of query (147 bits)
LYS4_ASPFU / Q4WUL6 Homoaconitase, mitochondrial; Homoaconitate hydratase; EC 4.2.1.36 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
25% identity, 98% coverage of query (144 bits)
ACON3_ASPFU / Q4WBR0 Putative aconitate hydratase; Aconitase 3; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
28% identity, 98% coverage of query (143 bits)
lys2 / RF|NP_593437.1 homoaconitate hydratase Lys2; EC 4.2.1.36 from Schizosaccharomyces pombe (see 2 papers)
28% identity, 87% coverage of query (142 bits)
LYS4_YEAST / P49367 Homoaconitase, mitochondrial; Homoaconitate hydratase; EC 4.2.1.36 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P49367 homoaconitate hydratase (EC 4.2.1.36) from Saccharomyces cerevisiae (see paper)
25% identity, 87% coverage of query (140 bits)
B1P2N4 homoaconitate hydratase (EC 4.2.1.36) from Penicillium chrysogenum (see paper)
26% identity, 92% coverage of query (137 bits)
ACON_ASPFU / Q4WLN1 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; Homocitrate dehydratase; EC 4.2.1.3; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
27% identity, 98% coverage of query (133 bits)
ACO1 aconitate hydratase; EC 4.2.1.3 from Candida albicans (see 2 papers)
28% identity, 98% coverage of query (132 bits)
ACON_EMENI / C8VG90 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; Homocitrate dehydratase; EC 4.2.1.3; EC 4.2.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
28% identity, 98% coverage of query (131 bits)
ACON_CAEEL / P34455 Probable aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Caenorhabditis elegans (see paper)
28% identity, 98% coverage of query (130 bits)
ACON_YEAST / P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
P19414 aconitate hydratase (EC 4.2.1.3) from Saccharomyces cerevisiae (see 2 papers)
28% identity, 83% coverage of query (130 bits)
ACON2_SCHPO / Q9P7D4 Aconitase-ribosomal protein bL21m fusion protein; EC 4.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
Q9P7D4 aconitate hydratase (EC 4.2.1.3) from Schizosaccharomyces pombe (see paper)
27% identity, 79% coverage of query (130 bits)
Aco / O74699 aconitase from Aspergillus terreus (see paper)
27% identity, 98% coverage of query (129 bits)
ACON2_YEAST / P39533 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
28% identity, 80% coverage of query (129 bits)
ACON2_ASPFU / Q4WJ90 Putative aconitate hydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
28% identity, 83% coverage of query (127 bits)
ACON2_EMENI / Q5B6D6 Putative aconitate hydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
27% identity, 79% coverage of query (118 bits)
AMT82_ALTAL / C9K7I3 Aconitase AMT8-2; AM-toxin biosynthesis protein 8-2; EC 4.2.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
28% identity, 73% coverage of query (113 bits)
AMT8_ALTAL / C9K7B9 Aconitase AMT8; AM-toxin biosynthesis protein 8; EC 4.2.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
28% identity, 73% coverage of query (113 bits)
D3GQL0 aconitate hydratase (EC 4.2.1.3) from Citrus clementina (see paper)
28% identity, 76% coverage of query (110 bits)
ACO1 / Q42560 aconitase from Arabidopsis thaliana (see paper)
ACO1_ARATH / Q42560 Aconitate hydratase 1; Aconitase 1; Citrate hydro-lyase 1; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q42560 aminocyclopropanecarboxylate oxidase (EC 1.14.17.4) from Arabidopsis thaliana (see paper)
28% identity, 76% coverage of query (109 bits)
ACON_BOVIN / P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see paper)
26% identity, 97% coverage of query (107 bits)
1b0kA S642a:fluorocitrate complex of aconitase
26% identity, 97% coverage of query (106 bits)
5acnA / P16276 Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
26% identity, 97% coverage of query (106 bits)
ACON_PIG / P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 4 papers)
26% identity, 97% coverage of query (106 bits)
8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound
26% identity, 97% coverage of query (106 bits)
1fghA Complex with 4-hydroxy-trans-aconitate
26% identity, 97% coverage of query (106 bits)
1amjA Steric and conformational features of the aconitase mechanism
26% identity, 97% coverage of query (106 bits)
1amiA Steric and conformational features of the aconitase mechanism
26% identity, 97% coverage of query (106 bits)
1acoA Crystal structure of aconitase with transaconitate bound
26% identity, 97% coverage of query (106 bits)
1nisA Crystal structure of aconitase with trans-aconitate and nitrocitrate bound
26% identity, 97% coverage of query (105 bits)
2b3xA / P21399 Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) (see paper)
27% identity, 76% coverage of query (103 bits)
ACO1 / P21399 cytoplasmic aconitate hydratase from Homo sapiens (see 6 papers)
ACOHC_HUMAN / P21399 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) (see 8 papers)
P21399 aconitate hydratase (EC 4.2.1.3) from Homo sapiens (see 3 papers)
27% identity, 76% coverage of query (103 bits)
ACO3M_ARATH / Q9SIB9 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q9SIB9 aconitate hydratase (EC 4.2.1.3) from Arabidopsis thaliana (see paper)
26% identity, 76% coverage of query (100 bits)
citB / P09339 aconitate hydratase (bifunctional aconitase) (EC 4.2.1.99; EC 4.2.1.3) from Bacillus subtilis (strain 168) (see 21 papers)
ACNA_BACSU / P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 7 papers)
P09339 aconitate hydratase (EC 4.2.1.3) from Bacillus subtilis (see paper)
28% identity, 76% coverage of query (87.4 bits)
A0QX20 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
25% identity, 76% coverage of query (79.0 bits)
3snpA / Q01059 Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA (see paper)
26% identity, 76% coverage of query (78.2 bits)
1l5jA / P36683 Crystal structure of e. Coli aconitase b. (see paper)
26% identity, 73% coverage of query (69.3 bits)
YacI / b0118 AcnB (EC 4.2.1.99) from Escherichia coli K-12 substr. MG1655 (see 20 papers)
acnB / P36683 AcnB (EC 4.2.1.99) from Escherichia coli (strain K12) (see 18 papers)
ACNB_ECOLI / P36683 Aconitate hydratase B; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Escherichia coli (strain K12) (see 9 papers)
P36683 aconitate hydratase (EC 4.2.1.3) from Escherichia coli (see 4 papers)
acnB / GB|AAZ86920.1 aconitate hydratas; EC 4.2.1.3 from Escherichia coli (see paper)
26% identity, 73% coverage of query (69.3 bits)
Or start over
Lawrence Berkeley National Laboratory