Sites on a Tree

 

Searching for up to 100 curated homologs for 14382 FitnessBrowser__Keio:14382 (417 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

Removed hits that are identical to the query, leaving 14

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A7Y114 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Halobacillus halophilus (see paper)
    46% identity, 100% coverage of query (373 bits)

P5CS1 / P54887 δ1-pyrroline-5-carboxylate synthetase (EC 1.2.1.41; EC 2.7.2.11) from Arabidopsis thaliana (see 4 papers)
    39% identity, 97% coverage of query (297 bits)

PROA_YEAST / P54885 Gamma-glutamyl phosphate reductase; GPR; Glutamate-5-semialdehyde dehydrogenase; GSA dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; EC 1.2.1.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    39% identity, 98% coverage of query (296 bits)

P5CS1_ORYSJ / O04226 Delta-1-pyrroline-5-carboxylate synthase 1; OsP5CS1; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice) (see paper)
    37% identity, 97% coverage of query (283 bits)

p5cs / CAB40834.1 pyrroline-5-carboxylate synthetase from Vitis vinifera (see paper)
    38% identity, 97% coverage of query (281 bits)

7wxgA / Q9VNW6 Gpr domain closed form of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
    36% identity, 98% coverage of query (271 bits)

P5CS2_ORYSJ / Q941T1 Delta-1-pyrroline-5-carboxylate synthase 2; OsP5CS2; EC 2.7.2.11; EC 1.2.1.41 from Oryza sativa subsp. japonica (Rice)
Q941T1 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Oryza sativa (see paper)
    34% identity, 97% coverage of query (271 bits)

7wxiA Gpr domain of drosophila p5cs filament with glutamate and atpgammas
    36% identity, 98% coverage of query (271 bits)

ALDH18A1 / P54886 δ-1-pyrroline-5-carboxylate synthase (EC 1.2.1.41; EC 2.7.2.11) from Homo sapiens (see 4 papers)
P5CS_HUMAN / P54886 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Homo sapiens (Human) (see 8 papers)
    36% identity, 98% coverage of query (261 bits)

P5CS_MOUSE / Q9Z110 Delta-1-pyrroline-5-carboxylate synthase; P5CS; Aldehyde dehydrogenase family 18 member A1; EC 2.7.2.11; EC 1.2.1.41 from Mus musculus (Mouse) (see paper)
Q9Z110 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) from Mus musculus (see paper)
    35% identity, 98% coverage of query (256 bits)

Echvi_2633 gamma-glutamylphosphate reductase (EC 1.2.1.41) from Echinicola vietnamensis KMM 6221, DSM 17526
    38% identity, 95% coverage of query (244 bits)

4jbeB / C7MW73 1.95 angstrom crystal structure of gamma-glutamyl phosphate reductase from saccharomonospora viridis.
    31% identity, 99% coverage of query (168 bits)

Build an alignment

Build an alignment for 14382 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

SQWD_ACHSX / A0A3A6N9T6 Sulfoacetaldehyde dehydrogenase; CoA-acylating sulfoacetaldehyde dehydrogenase; NAD(+)-dependent acylating sulfoacetaldehyde dehydrogenase; EC 1.2.1.- from Acholeplasma sp. (see paper)
    21% identity, 78% coverage of query (51.2 bits)

6gvsA Engineered glycolyl-coa reductase comprising 8 mutations with bound NADP+
    26% identity, 74% coverage of query (48.9 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory