Searching for up to 100 curated homologs for 14400 FitnessBrowser__Keio:14400 (348 a.a.)
Found high-coverage hits (≥70%) to 56 curated proteins.
Removed hits that are identical to the query, leaving 55
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.20.2 / Q9KLQ5 Fe(3+) ions import ATP-binding protein FbpC, component of Hexose-phosphate transporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
67% identity, 99% coverage of query (479 bits)
TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
62% identity, 98% coverage of query (443 bits)
TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
43% identity, 89% coverage of query (266 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
45% identity, 80% coverage of query (254 bits)
SM_b21106 ABC transporter for L-Fucose, ATPase component from Sinorhizobium meliloti 1021
45% identity, 80% coverage of query (254 bits)
A0A142UTH4 ABC-type polyamine transporter (subunit 4/4) (EC 7.6.2.11) from Streptococcus suis (see paper)
40% identity, 98% coverage of query (253 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
47% identity, 73% coverage of query (251 bits)
TC 3.A.1.11.7 / Q97Q42 Spermidine/putrescine import ATP-binding protein PotA, component of The spermidine/putrescine uptake porter, PotABCD from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
39% identity, 98% coverage of query (251 bits)
UgpC / b3450 sn-glycerol 3-phosphate ABC transporter ATP binding subunit (EC 7.6.2.10) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
UgpC / P10907 sn-glycerol 3-phosphate ABC transporter ATP binding subunit (EC 7.6.2.10) from Escherichia coli (strain K12) (see 2 papers)
UGPC_ECOLI / P10907 sn-glycerol-3-phosphate import ATP-binding protein UgpC; EC 7.6.2.10 from Escherichia coli (strain K12) (see 9 papers)
TC 3.A.1.1.3 / P10907 UgpC aka B3450, component of Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P from Escherichia coli (see 12 papers)
41% identity, 95% coverage of query (251 bits)
TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
42% identity, 88% coverage of query (249 bits)
TC 3.A.1.1.5 / P54933 SmoK aka POLK, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
45% identity, 80% coverage of query (249 bits)
SMc02869 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Sinorhizobium meliloti 1021
42% identity, 87% coverage of query (248 bits)
TC 3.A.1.1.22 / Q9X103 MalK; aka Sugar ABC transporter, ATP-binding protein, component of The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins from Thermotoga maritima (see paper)
45% identity, 79% coverage of query (248 bits)
Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
39% identity, 95% coverage of query (247 bits)
TC 3.A.1.1.10 / Q9KWT9 AlgS, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
algS / BAB03314.1 AlgS from Sphingomonas sp (see paper)
44% identity, 83% coverage of query (246 bits)
1g291 / Q9YGA6 Malk (see paper)
43% identity, 88% coverage of query (245 bits)
Q8YM92 ABC-type polyamine transporter (subunit 3/3) (EC 7.6.2.11) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
41% identity, 92% coverage of query (245 bits)
MALK_THELN / Q9YGA6 Trehalose/maltose import ATP-binding protein MalK; EC 7.5.2.1 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 5 papers)
43% identity, 85% coverage of query (245 bits)
CysA / b2422 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CysA / P16676 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.6.1 / P16676 CysA aka B2422, component of Sulfate/thiosulfate porter from Escherichia coli (see 5 papers)
44% identity, 80% coverage of query (244 bits)
SM_b20002 ABC transporter for Lactose, ATPase component from Sinorhizobium meliloti 1021
41% identity, 90% coverage of query (244 bits)
TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
40% identity, 94% coverage of query (243 bits)
Q8NMV1 ABC-type maltose transporter (EC 7.5.2.1) from Corynebacterium glutamicum (see paper)
TC 3.A.1.1.45 / Q8NMV1 ABC-type sugar transport system, ATPase component, component of Maltose transporter, MusEFGKI from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
44% identity, 78% coverage of query (242 bits)
PfGW456L13_1897 ABC transporter for D-Galactose and D-Glucose, ATPase component from Pseudomonas fluorescens GW456-L13
39% identity, 97% coverage of query (242 bits)
PGA1_c13180 ABC transporter for D-Sorbitol, ATPase component from Phaeobacter inhibens BS107
44% identity, 80% coverage of query (242 bits)
TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
41% identity, 90% coverage of query (241 bits)
PGA1_c27970 N-Acetyl-D-glucosamine ABC transport system, ATPase component from Phaeobacter inhibens BS107
42% identity, 87% coverage of query (241 bits)
8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
44% identity, 78% coverage of query (238 bits)
8hprC Lpqy-sugabc in state 4
43% identity, 80% coverage of query (237 bits)
8hprD Lpqy-sugabc in state 4
43% identity, 80% coverage of query (237 bits)
sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
43% identity, 78% coverage of query (233 bits)
2awnB / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
42% identity, 80% coverage of query (230 bits)
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state
42% identity, 80% coverage of query (230 bits)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3
42% identity, 80% coverage of query (230 bits)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4
42% identity, 80% coverage of query (230 bits)
3puvA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-vo4
42% identity, 80% coverage of query (230 bits)
1q12A Crystal structure of the atp-bound e. Coli malk
42% identity, 80% coverage of query (230 bits)
MalK / b4035 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 31 papers)
MalK / P68187 maltose ABC transporter ATP binding subunit (EC 7.5.2.1) from Escherichia coli (strain K12) (see 29 papers)
MALK_ECOLI / P68187 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Escherichia coli (strain K12) (see 6 papers)
P68187 ABC-type maltose transporter (subunit 3/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P68187 Maltose/maltodextrin import ATP-binding protein MalK aka B4035, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 17 papers)
malK / RF|NP_418459 maltose/maltodextrin import ATP-binding protein malK; EC 3.6.3.19 from Escherichia coli K12 (see 18 papers)
42% identity, 80% coverage of query (230 bits)
MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
38% identity, 87% coverage of query (228 bits)
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
36% identity, 86% coverage of query (214 bits)
1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
36% identity, 86% coverage of query (214 bits)
GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
36% identity, 86% coverage of query (214 bits)
2awnC / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
40% identity, 80% coverage of query (200 bits)
2awnA / P68187 Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
36% identity, 80% coverage of query (166 bits)
3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
35% identity, 78% coverage of query (163 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
34% identity, 70% coverage of query (152 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
34% identity, 70% coverage of query (152 bits)
Build an alignment for 14400 and 46 homologs with ≥ 30% identity
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ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
25% identity, 79% coverage of query (108 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
27% identity, 75% coverage of query (107 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
25% identity, 79% coverage of query (106 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
28% identity, 74% coverage of query (100 bits)
8i39A Cryo-em structure of abscisic acid transporter atabcg25 with aba
29% identity, 70% coverage of query (94.7 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
24% identity, 78% coverage of query (94.4 bits)
8i3cA Cryo-em structure of abscisic acid transporter atabcg25 with chs
29% identity, 72% coverage of query (93.6 bits)
8i3aA / Q84TH5 Cryo-em structure of abscisic acid transporter atabcg25 in outward conformation (see paper)
28% identity, 72% coverage of query (92.0 bits)
3gd7A / P13569,P68187 Crystal structure of human nbd2 complexed with n6-phenylethyl-atp (p- atp)
28% identity, 79% coverage of query (91.3 bits)
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Lawrence Berkeley National Laboratory