Sites on a Tree

 

Searching for up to 100 curated homologs for 14407 FitnessBrowser__Keio:14407 (655 a.a.)

Found high-coverage hits (≥70%) to 30 curated proteins.

Removed hits that are identical to the query, leaving 29

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YjhG / b4297 KpLE2 phage-like element; D-xylonate dehydratase (EC 4.2.1.82) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yjhG / P39358 KpLE2 phage-like element; D-xylonate dehydratase (EC 4.2.1.82) from Escherichia coli (strain K12) (see 7 papers)
YJHG_ECOLI / P39358 D-xylonate dehydratase YjhG; EC 4.2.1.82 from Escherichia coli (strain K12) (see 2 papers)
P39358 xylonate dehydratase (EC 4.2.1.82) from Escherichia coli (see paper)
yjhG / RF|NP_418717 uncharacterized protein yjhG from Escherichia coli K12 (see paper)
    68% identity, 98% coverage of query (899 bits)

6ovtA / P9WKJ5 Crystal structure of ilvd from mycobacterium tuberculosis (see paper)
    36% identity, 73% coverage of query (217 bits)

ILVD_MYCTU / P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    36% identity, 73% coverage of query (217 bits)

ilvD / Q0K7F8 dihydroxyacid dehydratase (EC 4.2.1.9) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
Q0K7F8 dihydroxy-acid dehydratase (EC 4.2.1.9) from Cupriavidus necator (see paper)
    37% identity, 74% coverage of query (205 bits)

Q97UB2 dihydroxy-acid dehydratase (EC 4.2.1.9) from Saccharolobus solfataricus (see 2 papers)
    33% identity, 74% coverage of query (204 bits)

ilvDD / O27498 dihydroxy-acid dehydratase subunit (EC 4.2.1.9) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see 4 papers)
    34% identity, 74% coverage of query (202 bits)

ILVD_ARATH / Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LIR4 dihydroxy-acid dehydratase (EC 4.2.1.9) from Arabidopsis thaliana (see 2 papers)
    30% identity, 83% coverage of query (191 bits)

A0A481UJA7 dihydroxy-acid dehydratase (EC 4.2.1.9) from Hevea brasiliensis (see paper)
    32% identity, 73% coverage of query (191 bits)

5ze4A / Q9LIR4 The structure of holo- structure of dhad complex with [2fe-2s] cluster (see paper)
    30% identity, 83% coverage of query (190 bits)

ILVD_RHIL3 / Q1MIB2 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    31% identity, 75% coverage of query (186 bits)

EDD_ZYMMO / P21909 Phosphogluconate dehydratase; 6-phosphogluconate dehydratase; EC 4.2.1.12 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see paper)
    33% identity, 76% coverage of query (186 bits)

ARAD_RHILW / B5ZZ34 L-arabinonate dehydratase; ArDHT; D-fuconate dehydratase; Galactonate dehydratase; L-arabonate dehydratase; EC 4.2.1.25; EC 4.2.1.67; EC 4.2.1.6 from Rhizobium leguminosarum bv. trifolii (strain WSM2304) (see 2 papers)
I9XDU6 L-Arabinonate dehydratase (EC 4.2.1.25) from Rhizobium leguminosarum bv. trifolii (see 2 papers)
    32% identity, 81% coverage of query (185 bits)

5j85A / I9XDU6 Ser480ala mutant of l-arabinonate dehydratase (see paper)
    32% identity, 81% coverage of query (183 bits)

IlvD / b3771 dihydroxy-acid dehydratase (EC 4.2.1.9) from Escherichia coli K-12 substr. MG1655 (see paper)
ilvD / P05791 dihydroxy-acid dehydratase (EC 4.2.1.9) from Escherichia coli (strain K12) (see 14 papers)
ILVD_ECOLI / P05791 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Escherichia coli (strain K12) (see 4 papers)
ilvD / EW|b3771 dihydroxyacid dehydratase from Escherichia coli K12 (see 2 papers)
    30% identity, 74% coverage of query (175 bits)

ARADA_AZOBR / Q1JUQ1 L-arabonate dehydratase; L-arabinonate dehydratase; EC 4.2.1.25 from Azospirillum brasilense (see paper)
Q1JUQ1 L-Arabinonate dehydratase (EC 4.2.1.25) from Azospirillum brasilense (see paper)
    32% identity, 72% coverage of query (173 bits)

ILVD_CAUVC / P55186 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see paper)
    30% identity, 75% coverage of query (164 bits)

Q8NQZ9 dihydroxy-acid dehydratase (EC 4.2.1.9) from Corynebacterium glutamicum (see 2 papers)
    31% identity, 75% coverage of query (159 bits)

ILVC_ASPFU / Q4X099 Dihydroxy-acid dehydratase ilvC, mitochondrial; DHAD ilvC; EC 4.2.1.9 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
    31% identity, 71% coverage of query (158 bits)

ILVD1_RHIME / Q92RP0 Putative dehydratase IlvD1; EC 4.2.1.- from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    31% identity, 77% coverage of query (152 bits)

salH / B0L7G4 dihydroxy-acid dehydratase from Salinispora tropica (see paper)
    32% identity, 71% coverage of query (150 bits)

Q1PAG1 phosphogluconate dehydratase (EC 4.2.1.12) from Pseudomonas chlororaphis (see paper)
    30% identity, 74% coverage of query (148 bits)

edd / CAE53634.1 6-phosphogluconate dehydratase from Nonomuraea gerenzanensis (see paper)
    30% identity, 72% coverage of query (142 bits)

Shewana3_2070 L-arabonate dehydratase (EC 4.2.1.25) from Shewanella sp. ANA-3
    30% identity, 72% coverage of query (141 bits)

Build an alignment

Build an alignment for 14407 and 23 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

SGD_PSEPU / P0DOV7 6-deoxy-6-sulfo-D-gluconate dehydratase; SG dehydratase; EC 4.2.1.162 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    28% identity, 72% coverage of query (137 bits)

Edd / b1851 phosphogluconate dehydratase (EC 4.2.1.12) from Escherichia coli K-12 substr. MG1655 (see 30 papers)
edd / P0ADF6 phosphogluconate dehydratase (EC 4.2.1.12) from Escherichia coli (strain K12) (see 29 papers)
EDD_ECOLI / P0ADF6 Phosphogluconate dehydratase; 6-phosphogluconate dehydratase; Entner-Doudoroff dehydrase; EC 4.2.1.12 from Escherichia coli (strain K12) (see 4 papers)
edd / RF|NP_416365 phosphogluconate dehydratase from Escherichia coli K12 (see 2 papers)
    28% identity, 81% coverage of query (132 bits)

Pf6N2E2_1668 Xylonate dehydratase (EC 4.2.1.82) from Pseudomonas fluorescens FW300-N2E2
    28% identity, 76% coverage of query (126 bits)

edd / AAA23722.1 6-phosphogluconate dehydratase from Escherichia coli (see paper)
    28% identity, 81% coverage of query (126 bits)

AO356_28760 Xylonate dehydratase (EC 4.2.1.82) from Pseudomonas fluorescens FW300-N2C3
    28% identity, 77% coverage of query (125 bits)

7m3kA / Q2YJ21 Crystal structure of galactonate dehydratase from brucella melitensis biovar abortus 2308
    29% identity, 75% coverage of query (122 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory