Searching for up to 100 curated homologs for 14442 FitnessBrowser__Keio:14442 (441 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
Removed hits that are identical to the query, leaving 99
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
6kgyB / P77212 Hocl-induced flavoprotein disulfide reductase rcla from escherichia coli (see paper)
100% identity, 100% coverage of query (905 bits)
6kyyA Cu(ii) complex of hocl-induced flavoprotein disulfide reductase rcla from escherichia coli
99% identity, 99% coverage of query (855 bits)
8ajjA Crystal structure of the disulfide reductase mera from staphylococcus aureus
50% identity, 99% coverage of query (429 bits)
8ajkB / Q2G0I4 Crystal structure of a c43s variant from the disulfide reductase mera from staphylococcus aureus (see paper)
49% identity, 100% coverage of query (427 bits)
P16171 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Bacillus cereus
33% identity, 98% coverage of query (258 bits)
A5N930 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Clostridium kluyveri (see paper)
33% identity, 99% coverage of query (241 bits)
MERA_LYSSH / D9J041 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Lysinibacillus sphaericus (Bacillus sphaericus) (see paper)
D9J041 mercury(II) reductase (EC 1.16.1.1) from Lysinibacillus sphaericus (see 2 papers)
31% identity, 98% coverage of query (240 bits)
5x1yB / D9J041 Structure of mercuric reductase from lysinibacillus sphaericus (see paper)
31% identity, 98% coverage of query (240 bits)
3ladA / P18925 Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
31% identity, 98% coverage of query (223 bits)
DLDH_AZOVI / P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see paper)
GI|142325 dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Azotobacter vinelandii (see 3 papers)
31% identity, 98% coverage of query (223 bits)
A0A0H2Z9F5 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Pseudomonas aeruginosa (see paper)
Q9I3D1 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Pseudomonas aeruginosa (see paper)
30% identity, 98% coverage of query (219 bits)
5u8uD / Q9I3D1 Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
30% identity, 98% coverage of query (219 bits)
5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh
30% identity, 98% coverage of query (219 bits)
5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+
30% identity, 98% coverage of query (219 bits)
Build an alignment for 14442 and 14 homologs with ≥ 30% identity
Or download the sequences
6awaA / Q88FB1 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from pseudomonas putida in complex with fad and adenosine-5'-monophosphate.
29% identity, 98% coverage of query (218 bits)
lpdG / GI|1256717 dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Pseudomonas putida (see 2 papers)
29% identity, 98% coverage of query (218 bits)
DLDH_PSEFL / P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see paper)
30% identity, 98% coverage of query (218 bits)
MERA_PSEAI / P00392 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Pseudomonas aeruginosa (see 2 papers)
30% identity, 98% coverage of query (217 bits)
4k8dA Crystal structure of the c558(464)a/c559(465)a double mutant of tn501 mera in complex with NADPH and hg2+
30% identity, 98% coverage of query (217 bits)
1ebdA / P11959 Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
30% identity, 97% coverage of query (216 bits)
DLDH1_GEOSE / P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
P11959 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Geobacillus stearothermophilus (see 2 papers)
pdhD / GB|CAA37631.1 dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Geobacillus stearothermophilus (see 4 papers)
30% identity, 97% coverage of query (215 bits)
B6F1A8 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Microbacterium luteolum (see paper)
30% identity, 99% coverage of query (212 bits)
pdhD / P21880 dihydrolipoyl dehydrogenase component subunit (EC 1.8.1.4) from Bacillus subtilis (strain 168) (see 2 papers)
pdhD / GB|CAB13334.1 dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Bacillus subtilis (see paper)
30% identity, 96% coverage of query (211 bits)
6uziC / A0A077ELH4 Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
30% identity, 99% coverage of query (209 bits)
4k7zA / P00392 Crystal structure of the c136(42)a/c141(47)a double mutant of tn501 mera in complex with NADP and hg2+
30% identity, 98% coverage of query (209 bits)
acoL TPP-dependent acetoin dehydrogenase complex, E3 component, dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Clostridium magnum (see paper)
AAA21748.1 dihydrolipoamide dehydrogenase from Clostridium magnum (see paper)
32% identity, 97% coverage of query (208 bits)
lpdA / O84561 dihydrolipoyl dehydrogenase subunit (EC 1.8.1.4) from Chlamydia trachomatis (strain D/UW-3/Cx) (see 4 papers)
30% identity, 98% coverage of query (207 bits)
E0XF09 mercury(II) reductase (EC 1.16.1.1) from Serratia marcescens (see paper)
29% identity, 98% coverage of query (203 bits)
3urhB / Q92LK0 Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
28% identity, 98% coverage of query (199 bits)
A8UT36 mercury(II) reductase (EC 1.16.1.1) from Hydrogenivirga sp. 128-5-R1-1 (see paper)
31% identity, 92% coverage of query (198 bits)
MERA_STRLI / P30341 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Streptomyces lividans (see paper)
32% identity, 93% coverage of query (197 bits)
T1RLH3 mercury(II) reductase (EC 1.16.1.1) from Flavobacterium sp. SOK62 (see paper)
27% identity, 98% coverage of query (197 bits)
Q93UN8 mercury(II) reductase (EC 1.16.1.1) from Escherichia coli (see paper)
29% identity, 97% coverage of query (196 bits)
4jdrA / P0A9P0 Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
28% identity, 98% coverage of query (194 bits)
Lpd / b0116 lipoamide dehydrogenase (EC 1.8.1.4) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
lpd / P0A9P0 lipoamide dehydrogenase (EC 1.8.1.4) from Escherichia coli (strain K12) (see 19 papers)
DLDH_ECOLI / P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see paper)
P0A9P0 pyruvate dehydrogenase system (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 1/3) (EC 1.2.1.105); glycine cleavage system (EC 1.4.1.27); dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Escherichia coli (see 4 papers)
lpd / SP|P0A9P1 dihydrolipoyl dehydrogenase; EC 1.8.1.4 from Escherichia coli K12 (see 10 papers)
28% identity, 98% coverage of query (194 bits)
DLDH_PEA / P31023 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Pyruvate dehydrogenase complex E3 subunit; E3; PDC-E3; EC 1.8.1.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
P31023 pyruvate dehydrogenase system (subunit 1/3) (EC 1.2.1.104); glycine cleavage system (subunit 4/4) (EC 1.4.1.27) from Pisum sativum (see 2 papers)
28% identity, 95% coverage of query (192 bits)
1dxlA / P31023 Dihydrolipoamide dehydrogenase of glycine decarboxylase from pisum sativum (see paper)
28% identity, 95% coverage of query (192 bits)
P48642 glutathione-disulfide reductase (EC 1.8.1.7) from Oryza sativa (see 2 papers)
29% identity, 99% coverage of query (191 bits)
V5TDP2 mercury(II) reductase (EC 1.16.1.1) from uncultured bacterium (see paper)
28% identity, 98% coverage of query (190 bits)
3o0hB / A0A0H3LWY9 Crystal structure of glutathione reductase from bartonella henselae
29% identity, 98% coverage of query (190 bits)
DLD / Q5ZM32 lipoamide dehydrogenase (EC 1.8.1.4) from Gallus gallus (see 6 papers)
29% identity, 97% coverage of query (189 bits)
4ywoA / A4YG49 Mercuric reductase from metallosphaera sedula (see paper)
28% identity, 98% coverage of query (189 bits)
A4YG49 mercury(II) reductase (EC 1.16.1.1) from Metallosphaera sedula (see paper)
28% identity, 98% coverage of query (189 bits)
A0A068EUE1 glutathione-disulfide reductase (EC 1.8.1.7) from Cenchrus americanus (see paper)
29% identity, 99% coverage of query (188 bits)
A8CCK8 glutathione-disulfide reductase (EC 1.8.1.7) from Hordeum vulgare (see paper)
29% identity, 99% coverage of query (187 bits)
DLDH_THESS / P85207 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; EC 1.8.1.4 from Thermus scotoductus (strain ATCC 700910 / SA-01) (see paper)
29% identity, 99% coverage of query (187 bits)
1zmdA Crystal structure of human dihydrolipoamide dehydrogenase complexed to nadh
30% identity, 97% coverage of query (187 bits)
1zmcA Crystal structure of human dihydrolipoamide dehydrogenase complexed to NAD+
30% identity, 97% coverage of query (187 bits)
LEGRE_SOYBN / Q41219 Leghemoglobin reductase; Ferric leghemoglobin reductase; FLbR; EC 1.6.2.6 from Glycine max (Soybean) (Glycine hispida) (see paper)
28% identity, 95% coverage of query (186 bits)
LPD1 / Q9M5K3 glycine cleavage system L protein 1 from Arabidopsis thaliana (see 3 papers)
DLDH1_ARATH / Q9M5K3 Dihydrolipoyl dehydrogenase 1, mitochondrial; AtmLPD1; mtLPD1; Dihydrolipoamide dehydrogenase 1; Glycine cleavage system L protein 1; Pyruvate dehydrogenase complex E3 subunit 1; E3-1; PDC-E3 1; EC 1.8.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9M5K3 glycine cleavage system (subunit 5/5) (EC 1.4.1.27) from Arabidopsis thaliana (see paper)
28% identity, 95% coverage of query (186 bits)
O81413 leghemoglobin reductase (EC 1.6.2.6); dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Glycine max (see paper)
28% identity, 95% coverage of query (186 bits)
DLD / P09622 dihydrolipoyl dehydrogenase monomer from Homo sapiens (see 11 papers)
DLDH_HUMAN / P09622 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; EC 1.8.1.4 from Homo sapiens (Human) (see 18 papers)
A0A024R713 2-oxoglutarate dehydrogenase system (subunit 3/3) (EC 1.2.1.105) from Homo sapiens (see paper)
P09622 pyruvate dehydrogenase system (subunit 1/5) (EC 1.2.1.104); 2-oxoglutarate dehydrogenase system (subunit 1/3) (EC 1.2.1.105); glycine cleavage system (subunit 1/4) (EC 1.4.1.27); dihydrolipoyl dehydrogenase (EC 1.8.1.4); dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (EC 2.3.1.168) from Homo sapiens (see 16 papers)
30% identity, 97% coverage of query (186 bits)
6hg8B / P09622 Crystal structure of the r460g disease-causing mutant of the human dihydrolipoamide dehydrogenase.
30% identity, 97% coverage of query (185 bits)
DLDH_BOVIN / F1N206 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; EC 1.8.1.4 from Bos taurus (Bovine) (see paper)
30% identity, 97% coverage of query (185 bits)
1jehA / P09624 Crystal structure of yeast e3, lipoamide dehydrogenase (see paper)
31% identity, 98% coverage of query (185 bits)
DLDH_YEAST / P09624 Dihydrolipoyl dehydrogenase, mitochondrial; DLD; 2-oxoglutarate dehydrogenase complex component E3; OGDC-E3; OGDHC subunit E3; Alpha-ketoglutarate dehydrogenase complex subunit E3; alpha-KGDHC subunit E3; Dihydrolipoamide dehydrogenase; Dihydrolipoamide:NAD(+) oxidoreductase; Glycine decarboxylase complex subunit L; GDC subunit L; Lipoamide dehydrogenase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex E3 component; PDC subunit E3; PDH complex subunit E3; EC 1.8.1.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
31% identity, 98% coverage of query (185 bits)
1v59A Crystal structure of yeast lipoamide dehydrogenase complexed with NAD+
31% identity, 98% coverage of query (185 bits)
DLDH_MESAU / Q811C4 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; EC 1.8.1.4 from Mesocricetus auratus (Golden hamster) (see 2 papers)
30% identity, 97% coverage of query (184 bits)
DLDH_PIG / P09623 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; EC 1.8.1.4 from Sus scrofa (Pig) (see paper)
P09623 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Sus scrofa (see paper)
29% identity, 97% coverage of query (184 bits)
DLDH2_ARATH / Q9M5K2 Dihydrolipoyl dehydrogenase 2, mitochondrial; AtmLPD2; mtLPD2; Dihydrolipoamide dehydrogenase 2; Glycine cleavage system L protein 2; Pyruvate dehydrogenase complex E3 subunit 2; E3-2; PDC-E3 2; EC 1.8.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9M5K2 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Arabidopsis thaliana (see paper)
28% identity, 95% coverage of query (184 bits)
DLDH_MOUSE / O08749 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; EC 1.8.1.4 from Mus musculus (Mouse) (see 3 papers)
O08749 glycine cleavage system (subunit 1/2) (EC 1.4.1.27) from Mus musculus (see 2 papers)
29% identity, 97% coverage of query (182 bits)
7kmyA / P9WHH9 Structure of mtb lpd bound to 010705 (see paper)
29% identity, 99% coverage of query (178 bits)
4m52A Structure of mtb lpd bound to sl827
29% identity, 99% coverage of query (178 bits)
8u0qA Co-crystal structure of optimized analog tdi-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series
29% identity, 99% coverage of query (178 bits)
8ct4A Cryo-em structure of mtb lpd bound to inhibitor complex with 2-((2- cyano-n,5-dimethyl-1h-indole)-7-sulfonamido)-n-(4-(oxetan-3-yl)-3,4- dihydro-2h-benzo[b] [1,4]oxazin-7-yl)acetamide
29% identity, 99% coverage of query (178 bits)
DLDH_MYCTU / P9WHH9 Dihydrolipoyl dehydrogenase; LPD; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide dehydrogenase; E3 component of alpha-ketoacid dehydrogenase complexes; EC 1.8.1.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 6 papers)
P9WHH8 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Mycobacterium tuberculosis (see paper)
P9WHH9 dihydrolipoyl dehydrogenase (EC 1.8.1.4) from Mycobacterium tuberculosis (see paper)
29% identity, 99% coverage of query (178 bits)
6bz0A / D0CDT4 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from acinetobacter baumannii in complex with fad.
26% identity, 98% coverage of query (177 bits)
6aonA / Q7VZ16 1.72 angstrom resolution crystal structure of 2-oxoglutarate dehydrogenase complex subunit dihydrolipoamide dehydrogenase from bordetella pertussis in complex with fad
28% identity, 98% coverage of query (177 bits)
2eq7A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8 with psbdo
29% identity, 98% coverage of query (177 bits)
2yquB Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
29% identity, 98% coverage of query (177 bits)
2yquA / Q5SLK6 Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
29% identity, 98% coverage of query (177 bits)
3ii4A Structure of mycobacterial lipoamide dehydrogenase bound to a triazaspirodimethoxybenzoyl inhibitor
29% identity, 98% coverage of query (176 bits)
2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD
29% identity, 99% coverage of query (176 bits)
2qaeA / P90597 Crystal structure analysis of trypanosoma cruzi lipoamide dehydrogenase
27% identity, 95% coverage of query (174 bits)
2r9zB / D0VWY5 Glutathione amide reductase from chromatium gracile (see paper)
28% identity, 99% coverage of query (171 bits)
GASHR_MARGR / D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
29% identity, 99% coverage of query (170 bits)
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex
28% identity, 98% coverage of query (166 bits)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme
28% identity, 98% coverage of query (166 bits)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex
28% identity, 98% coverage of query (166 bits)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex
28% identity, 98% coverage of query (166 bits)
2eq6A / Q5SLR0 Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8
26% identity, 99% coverage of query (165 bits)
1geuA Anatomy of an engineered NAD-binding site
28% identity, 93% coverage of query (164 bits)
3djjA / P00390 Catalytic cycle of human glutathione reductase near 1 a resolution (see paper)
28% identity, 94% coverage of query (157 bits)
4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase
28% identity, 94% coverage of query (157 bits)
3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity
28% identity, 94% coverage of query (157 bits)
2gh5A Crystal structure of human glutathione reductase complexed with a fluoro-analogue of the menadione derivative m5
28% identity, 94% coverage of query (157 bits)
2aaqA Crystal structure analysis of the human glutahione reductase, complexed with gopi
28% identity, 94% coverage of query (157 bits)
1xanA Human glutathione reductase in complex with a xanthene inhibitor
28% identity, 94% coverage of query (157 bits)
1grbA Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 angstroms resolution
28% identity, 94% coverage of query (157 bits)
1dncA Human glutathione reductase modified by diglutathione-dinitroso-iron
28% identity, 94% coverage of query (157 bits)
1bwcA Structure of human glutathione reductase complexed with ajoene inhibitor and subversive substrate
28% identity, 94% coverage of query (157 bits)
GSR / P00390 glutathione reductase subunit (EC 1.8.1.7) from Homo sapiens (see 6 papers)
GSHR_HUMAN / P00390 Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7 from Homo sapiens (Human) (see 2 papers)
28% identity, 94% coverage of query (157 bits)
P06715 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Escherichia coli (strain K12)
28% identity, 93% coverage of query (156 bits)
1getA Anatomy of an engineered NAD-binding site
28% identity, 93% coverage of query (156 bits)
1gerB / P06715 The structure of glutathione reductase from escherichia coli at 1.86 angstroms resolution: comparison with the enzyme from human erythrocytes (see paper)
28% identity, 93% coverage of query (156 bits)
6du7A / A0A0U0ARX4 Glutathione reductase from streptococcus pneumoniae (see paper)
29% identity, 93% coverage of query (155 bits)
DLDH1_PSEPU / P09063 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of branched-chain alpha-keto acid dehydrogenase complex; LPD-Val; EC 1.8.1.4 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
27% identity, 90% coverage of query (154 bits)
1lvlA / P09063 The refined structure of pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 angstroms resolution (see paper)
27% identity, 90% coverage of query (154 bits)
5vdnA / Q8CZL0 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
27% identity, 93% coverage of query (151 bits)
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