Searching for up to 100 curated homologs for 14521 FitnessBrowser__Keio:14521 (471 a.a.)
Found high-coverage hits (≥70%) to 65 curated proteins.
Removed hits that are identical to the query, leaving 60
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1ajbA / P00634 Three-dimensional structure of the d153g mutant of e. Coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity (see paper)
100% identity, 95% coverage of query (916 bits)
3dpcB Structure of e.Coli alkaline phosphatase mutant in complex with a phosphorylated peptide
100% identity, 95% coverage of query (916 bits)
1alhA Kinetics and crystal structure of a mutant e. Coli alkaline phosphatase (asp-369-->asn): a mechanism involving one zinc per active site
100% identity, 95% coverage of query (912 bits)
1kh5A E. Coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
99% identity, 94% coverage of query (900 bits)
7tm9A / A0A0H3GK94 Crystal structure of bacterial alkaline phosphatase from klebsiella pneumoniae
90% identity, 94% coverage of query (802 bits)
PPBH_PSEAE / P35483 Alkaline phosphatase H; High molecular weight phosphatase; H-AP; EC 3.1.3.1 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
74% identity, 94% coverage of query (685 bits)
PPBH_PSEAB / Q02QC9 Alkaline phosphatase H; High molecular weight phosphatase; H-AP; EC 3.1.3.1 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
74% identity, 94% coverage of query (682 bits)
strK / P09401 streptomycin-6-phosphatase (EC 3.1.3.39) from Streptomyces griseus (see paper)
50% identity, 87% coverage of query (351 bits)
phoAIV / CAA74486.1 alkaline phosphatase from Bacillus subtilis (see 3 papers)
32% identity, 84% coverage of query (153 bits)
P19406 alkaline phosphatase (EC 3.1.3.1) from Bacillus subtilis (see paper)
32% identity, 84% coverage of query (152 bits)
A8WEG4 alkaline phosphatase (EC 3.1.3.1) from Geobacillus thermodenitrificans (see paper)
33% identity, 86% coverage of query (152 bits)
A0A218PHN9 alkaline phosphatase (EC 3.1.3.1) from Shewanella sp. T3-3 (see paper)
35% identity, 70% coverage of query (149 bits)
Build an alignment for 14521 and 12 homologs with ≥ 30% identity
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2w5vA / Q9KWY4 Structure of tab5 alkaline phosphatase mutant his 135 asp with mg bound in the m3 site. (see paper)
28% identity, 86% coverage of query (146 bits)
Q9KWY4 alkaline phosphatase (EC 3.1.3.1) from Antarctic bacterium TAB5 (see 2 papers)
28% identity, 86% coverage of query (144 bits)
2iucA Structure of alkaline phosphatase from the antarctic bacterium tab5
30% identity, 86% coverage of query (143 bits)
3mk0A / P05187 Refinement of placental alkaline phosphatase complexed with nitrophenyl (see paper)
28% identity, 95% coverage of query (141 bits)
PPB1_HUMAN / P05187 Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; EC 3.1.3.1 from Homo sapiens (Human) (see 9 papers)
28% identity, 95% coverage of query (141 bits)
1zefA Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
28% identity, 95% coverage of query (141 bits)
1zedA Alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate
28% identity, 95% coverage of query (141 bits)
Pho8 / P11491 farnesyl diphosphatase (EC 3.1.3.1; EC 3.1.7.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
PPB_YEAST / P11491 Repressible alkaline phosphatase; Fructose-2,6-bisphosphate 6-phosphatase; Membrane-bound repressible alkaline phosphatase; EC 3.1.3.1; EC 3.1.3.54; EC 3.1.7.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
33% identity, 72% coverage of query (140 bits)
PPBN_HUMAN / P10696 Alkaline phosphatase, germ cell type; ALP-1; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase, placental-like; Germ cell alkaline phosphatase; GCAP; Placental alkaline phosphatase-like; PLAP-like; EC 3.1.3.1 from Homo sapiens (Human) (see paper)
28% identity, 95% coverage of query (140 bits)
2glqA X-ray structure of human alkaline phosphatase in complex with strontium
28% identity, 95% coverage of query (140 bits)
1ew2A Crystal structure of a human phosphatase
28% identity, 95% coverage of query (140 bits)
PPBI1_RAT / P15693 Intestinal-type alkaline phosphatase 1; IAP-1; Intestinal alkaline phosphatase 1; Intestinal alkaline phosphatase I; IAP-I; EC 3.1.3.1 from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 94% coverage of query (135 bits)
4kjgA / P15693 Structure of rat intestinal alkaline phosphatase expressed in insect cell (see paper)
28% identity, 94% coverage of query (135 bits)
Q93P54 alkaline phosphatase (EC 3.1.3.1) from Vibrio sp. (see paper)
33% identity, 72% coverage of query (134 bits)
PPBN_MOUSE / P24823 Alkaline phosphatase, germ cell type; Alkaline phosphatase 5; Alkaline phosphatase, placental-like; Embryonic alkaline phosphatase; EAP; Embryonic-type alkaline phosphatase; EC 3.1.3.1 from Mus musculus (Mouse) (see 2 papers)
28% identity, 95% coverage of query (134 bits)
Q1W622 alkaline phosphatase (EC 3.1.3.1) from Cobetia marina (see paper)
32% identity, 73% coverage of query (134 bits)
A1X864 protein-tyrosine-phosphatase (EC 3.1.3.48) from Metarhizium anisopliae (see paper)
34% identity, 70% coverage of query (129 bits)
1k7hA / Q9BHT8 Crystal structure of shrimp alkaline phosphatase (see paper)
33% identity, 72% coverage of query (129 bits)
PPBT_FELCA / Q29486 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Felis catus (Cat) (Felis silvestris catus) (see paper)
32% identity, 73% coverage of query (128 bits)
PPBT_BOVIN / P09487 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Bos taurus (Bovine) (see paper)
P09487 alkaline phosphatase (EC 3.1.3.1) from Bos taurus (see 2 papers)
33% identity, 73% coverage of query (127 bits)
PPBT_RAT / P08289 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Rattus norvegicus (Rat) (see paper)
P08289 alkaline phosphatase (EC 3.1.3.1) from Rattus norvegicus (see paper)
32% identity, 72% coverage of query (127 bits)
PPB_GADMO / P83456 Alkaline phosphatase; AP; EC 3.1.3.1 from Gadus morhua (Atlantic cod) (see paper)
31% identity, 74% coverage of query (127 bits)
1shqA Crystal structure of shrimp alkaline phosphatase with magnesium in m3
33% identity, 72% coverage of query (127 bits)
1shnA Crystal structure of shrimp alkaline phosphatase with phosphate bound
33% identity, 72% coverage of query (127 bits)
PPBT_HUMAN / P05186 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNS-ALP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Homo sapiens (Human) (see 41 papers)
P05186 alkaline phosphatase (EC 3.1.3.1) from Homo sapiens (see 6 papers)
32% identity, 72% coverage of query (125 bits)
PPBT_CHICK / Q92058 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; Phosphoamidase; EC 3.1.3.1 from Gallus gallus (Chicken) (see 2 papers)
32% identity, 72% coverage of query (125 bits)
7yivA / P05186 The crystal structure of human tissue nonspecific alkaline phosphatase (alpl) at basic ph (see paper)
32% identity, 72% coverage of query (125 bits)
PPBI_MOUSE / P24822 Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase; Alkaline phosphatase 3; EC 3.1.3.1 from Mus musculus (Mouse) (see paper)
P24822 alkaline phosphatase (EC 3.1.3.1) from Mus musculus (see paper)
29% identity, 86% coverage of query (124 bits)
PPBT_MOUSE / P09242 Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNAP; TNSALP; Alkaline phosphatase 2; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; EC 3.1.3.1; EC 3.9.1.1 from Mus musculus (Mouse) (see 22 papers)
31% identity, 72% coverage of query (124 bits)
D1.8 / CAJ14151.1 putative alkaline phosphatase from Anopheles gambiae (see paper)
29% identity, 72% coverage of query (120 bits)
Q17TZ1 alkaline phosphatase (EC 3.1.3.1) from Pinctada fucata (see paper)
28% identity, 86% coverage of query (119 bits)
A8TKU6 alkaline phosphatase (EC 3.1.3.1) from Schistosoma mansoni (see paper)
29% identity, 90% coverage of query (119 bits)
P19111 alkaline phosphatase (EC 3.1.3.1) from Bos taurus (see 3 papers)
27% identity, 94% coverage of query (117 bits)
P19111 Intestinal-type alkaline phosphatase; IAP; Intestinal alkaline phosphatase; EC 3.1.3.1 from Bos taurus (Bovine)
27% identity, 94% coverage of query (117 bits)
C3U1W0 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
27% identity, 87% coverage of query (115 bits)
PPBI2_RAT / P51740 Intestinal-type alkaline phosphatase 2; IAP-2; Intestinal alkaline phosphatase 2; Intestinal alkaline phosphatase II; IAP-II; EC 3.1.3.1 from Rattus norvegicus (Rat) (see paper)
30% identity, 70% coverage of query (115 bits)
C3U1V9 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
27% identity, 87% coverage of query (114 bits)
A0A1E3P771 alkaline phosphatase (EC 3.1.3.1) from Wickerhamomyces anomalus (see paper)
30% identity, 70% coverage of query (114 bits)
C3U1W1 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
27% identity, 87% coverage of query (112 bits)
C3U1W2 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
27% identity, 90% coverage of query (112 bits)
B4X983 alkaline phosphatase (EC 3.1.3.1) from Heliothis virescens (see paper)
27% identity, 87% coverage of query (112 bits)
B4Z1D6 alkaline phosphatase (EC 3.1.3.1) from Helicoverpa armigera (see 2 papers)
27% identity, 88% coverage of query (111 bits)
APH4_DROME / Q24238 Alkaline phosphatase 4; EC 3.1.3.1 from Drosophila melanogaster (Fruit fly) (see paper)
28% identity, 75% coverage of query (108 bits)
B4Z1D7 alkaline phosphatase (EC 3.1.3.1) from Helicoverpa armigera (see 2 papers)
27% identity, 88% coverage of query (105 bits)
Q153J0 alkaline phosphatase (EC 3.1.3.1) from Thermus thermophilus (see paper)
30% identity, 71% coverage of query (104 bits)
7kwdA / Q53W95 Crystal structure of thermus thermophilus alkaline phosphatase (see paper)
30% identity, 71% coverage of query (104 bits)
2x98A / B0R9W3 H.Salinarum alkaline phosphatase (see paper)
32% identity, 70% coverage of query (102 bits)
B0R9W3 alkaline phosphatase (EC 3.1.3.1) from Halobacterium salinarum (see paper)
32% identity, 70% coverage of query (102 bits)
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Lawrence Berkeley National Laboratory