Searching for up to 100 curated homologs for 14823 FitnessBrowser__Keio:14823 (439 a.a.)
Found high-coverage hits (≥70%) to 32 curated proteins.
Removed hits that are identical to the query, leaving 31
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ADIC_SALTY / P60066 Arginine/agmatine antiporter from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
33% identity, 100% coverage of query (256 bits)
YjdD / b4115 arginine:agmatine antiporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
adiC / P60061 arginine:agmatine antiporter from Escherichia coli (strain K12) (see 2 papers)
ADIC_ECOLI / P60061 Arginine/agmatine antiporter from Escherichia coli (strain K12) (see 6 papers)
ADIC_ECO57 / P60063 Arginine/agmatine antiporter from Escherichia coli O157:H7 (see 3 papers)
TC 2.A.3.2.5 / P60061 Homodimeric electrogenic arginine (Km=80μM):agmatine antiporter, AdiC, involved in extreme acid resistance (Fang et al., 2007; Gong et al., 2003; Iyer et al., 2003). A projection structure at 6.5 Å resolution has been published (Casagrande et al., 2008), and the 3.2 Å resolution X-ray structure was determined by Fang et al., 2009 and Gao et al., 2009 from Escherichia coli (see 6 papers)
adiC / GB|AAN45533.1 arginine/agmatine antiporter from Shigella flexneri (see 6 papers)
33% identity, 100% coverage of query (254 bits)
5j4nA / P60061 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution (see paper)
33% identity, 99% coverage of query (253 bits)
3l1lA Structure of arg-bound escherichia coli adic
32% identity, 99% coverage of query (234 bits)
CadB / b4132 lysine:cadaverine antiporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
CadB / P0AAE8 lysine:cadaverine antiporter from Escherichia coli (strain K12) (see 12 papers)
CADB_ECOLI / P0AAE8 Cadaverine/lysine antiporter from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.2.2 / P0AAE8 Cadaverine:lysine antiporter [Catalyzes cadaverine uptake via H+ symport (Km=21μM) and cadaverine export (Km=300 μM) via cadaverine:lysine antiport.] (Soksawatmaekhin et al., 2004). Modeling tools have been used to gain information about the structures and functions of CadB and PotE in E. coli from Escherichia coli (see 6 papers)
32% identity, 92% coverage of query (183 bits)
Build an alignment for 14823 and 5 homologs with ≥ 30% identity
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YdgI / b1605 putative arginine:ornithine antiporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ARCD_ECOLI / P0AAE5 Putative arginine/ornithine antiporter from Escherichia coli (strain K12) (see paper)
27% identity, 93% coverage of query (107 bits)
AAXC_CHLPN / Q9Z6M8 Arginine/agmatine antiporter from Chlamydia pneumoniae (Chlamydophila pneumoniae) (see paper)
TC 2.A.3.2.7 / Q9Z6M8 Arginine/agmatine antiporter from Chlamydia pneumoniae (see 4 papers)
25% identity, 97% coverage of query (82.0 bits)
TC 2.A.3.3.23 / S6EX81 Branched chain amino acid (Leucine/isoleucine/valine) uptake transporter of 469 aas and 12 TMSs, BcaP or CitA from Lactococcus lactis subsp. lactis A12
23% identity, 70% coverage of query (76.6 bits)
ARCD_PSEAE / P18275 Arginine/ornithine antiporter; Arginine-ornithine exchanger from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
TC 2.A.3.2.3 / P18275 Arginine:ornithine antiporter from Pseudomonas aeruginosa (see 3 papers)
arcD / GB|AAG08555.1 arginine/ornithine antiporter from Pseudomonas aeruginosa (see 3 papers)
23% identity, 93% coverage of query (75.5 bits)
arcD / CAA04686.1 arginine /ornithine antiporter from Lactobacillus sakei (see 2 papers)
25% identity, 73% coverage of query (75.1 bits)
TC 2.A.3.2.11 / F2HL56 Arginine/Ornithine antiporter of 526 aas and 14 TMSs from Lactococcus lactis subsp. lactis (strain CV56)
23% identity, 99% coverage of query (72.0 bits)
ARCD1_LACLM / A2RNI5 Arginine/ornithine antiporter ArcD1; Arginine/ornithine exchanger from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
23% identity, 99% coverage of query (71.6 bits)
6f2wA / A8UCQ5 Bacterial asc transporter crystal structure in open to in conformation (see paper)
22% identity, 97% coverage of query (70.1 bits)
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
24% identity, 71% coverage of query (62.8 bits)
AIMA_BACSU / Q45577 Glutamate/serine transporter AimA; Amino acid importer A from Bacillus subtilis (strain 168) (see 2 papers)
23% identity, 91% coverage of query (62.4 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
25% identity, 85% coverage of query (61.6 bits)
CAAT9_ARATH / Q9C5D6 Cationic amino acid transporter 9, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 71% coverage of query (59.7 bits)
GADC_LACLM / O30417 Glutamate/gamma-aminobutyrate antiporter; Glu/GABA antiporter from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
TC 2.A.3.7.1 / O30417 Glutamate:γ-aminobutyrate antiporter of 477 aas and 12 TMSs, GadC from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (see 3 papers)
22% identity, 77% coverage of query (56.2 bits)
Q16N01 ABC-type polar-amino-acid transporter (EC 7.4.2.1) from Aedes aegypti (see paper)
22% identity, 84% coverage of query (55.8 bits)
MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
20% identity, 72% coverage of query (54.3 bits)
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
22% identity, 86% coverage of query (53.9 bits)
LAT2_RAT / Q9WVR6 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.3.8.6 / Q9WVR6 L-type neutral amino acid transporter, LAT2 (Na+-independent with broad specificity for all L-isomers of neutral amino acids; preferred substrate: Phe, His, Trp, Ile, Val, Leu, Gln, Cys, Ser; catalyzes obligatory exchange with μM affinities on the outside and mM affinities on the inside [1000x difference]). Both LAT2 and LAT1 (2.A.3.8.1) catalyze uptake of S-nitro-L-cysteine (Li and Whorton, 2005). Also transports thyroid hormones from Rattus norvegicus (Rat) (see 3 papers)
22% identity, 86% coverage of query (53.9 bits)
SLC7A11 / Q9UPY5 cystine/glutamate transporter from Homo sapiens (see paper)
XCT_HUMAN / Q9UPY5 Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT from Homo sapiens (Human) (see 9 papers)
TC 2.A.3.8.18 / Q9UPY5 Cystine/glutamate antiporter (Amino acid transport system xCT) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) from Homo sapiens (see 7 papers)
26% identity, 71% coverage of query (53.5 bits)
7epzB Overall structure of erastin-bound xct-4f2hc complex
25% identity, 71% coverage of query (53.5 bits)
7p9uB / Q9UPY5 Cryo em structure of system xc- in complex with glutamate (see paper)
25% identity, 71% coverage of query (53.5 bits)
LAT2_MOUSE / Q9QXW9 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) (see 6 papers)
22% identity, 95% coverage of query (52.8 bits)
7cmiB The lat2-4f2hc complex in complex with leucine
22% identity, 82% coverage of query (52.0 bits)
7cmhB / Q9UHI5 The lat2-4f2hc complex in complex with tryptophan (see paper)
22% identity, 82% coverage of query (52.0 bits)
7b00A Human lat2-4f2hc complex in the apo-state
22% identity, 82% coverage of query (52.0 bits)
AAT6_CAEEL / Q22397 Amino acid transporter protein 6 from Caenorhabditis elegans (see 2 papers)
TC 2.A.3.8.27 / Q22397 Amino acid transporter 6 (AAT-6). Interacts with NRFL-1, the C. elegans NHERF orthologue to promote localization to the intestinal luminal membrane from Caenorhabditis elegans
24% identity, 75% coverage of query (50.8 bits)
YjeH / b4141 L-methionine/branched chain amino acid exporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
yjeH / P39277 L-methionine/branched chain amino acid exporter from Escherichia coli (strain K12) (see 3 papers)
YJEH_ECOLI / P39277 L-methionine/branched-chain amino acid exporter YjeH from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.3.13.1 / P39277 The hydrophobic amino acid efflux transporter, YjeH from Escherichia coli (see 4 papers)
23% identity, 71% coverage of query (44.7 bits)
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Lawrence Berkeley National Laboratory