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Searching for up to 100 curated homologs for 14882 FitnessBrowser__Keio:14882 (382 a.a.)

Found high-coverage hits (≥70%) to 51 curated proteins.

Removed hits that are identical to the query, leaving 50

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A0A085HKM4 galactokinase (EC 2.7.1.6) from Leminorella grimontii (see paper)
    68% identity, 100% coverage of query (547 bits)

B1KRG2 glucokinase (EC 2.7.1.2) from Shewanella woodyi (see paper)
    61% identity, 99% coverage of query (488 bits)

B1KDE7 glucokinase (EC 2.7.1.2) from Shewanella woodyi (see paper)
    47% identity, 99% coverage of query (370 bits)

B1KD89 glucokinase (EC 2.7.1.2) from Shewanella woodyi (see paper)
    44% identity, 96% coverage of query (326 bits)

B2UQR6 galactokinase (EC 2.7.1.6) from Akkermansia muciniphila (see paper)
    44% identity, 98% coverage of query (301 bits)

GALK1 / P51570 galactokinase (EC 2.7.1.6) from Homo sapiens (see 5 papers)
GALK1_HUMAN / P51570 Galactokinase; Galactose kinase; EC 2.7.1.6 from Homo sapiens (Human) (see 8 papers)
P51570 galactokinase (EC 2.7.1.6) from Homo sapiens (see 6 papers)
    45% identity, 97% coverage of query (287 bits)

GALK1_MOUSE / Q9R0N0 Galactokinase; Galactose kinase; EC 2.7.1.6 from Mus musculus (Mouse) (see paper)
    45% identity, 97% coverage of query (286 bits)

6q3xA / P51570 Structure of human galactokinase in complex with galactose and 2'- (benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'h-spiro[cyclohexane-1,4'- quinazolin]-5'(6'h)-one (see paper)
    45% identity, 97% coverage of query (286 bits)

6q3wC Structure of human galactokinase 1 bound with ethyl 1-(2-pyrazinyl)-4- piperidinecarboxylate
    45% identity, 97% coverage of query (286 bits)

6q8zA Structure of human galactokinase 1 bound with n-(cyclobutylmethyl)-1, 5-dimethyl-1h-pyrazole-4-carboxamide
    45% identity, 97% coverage of query (286 bits)

6qjeA Structure of human galactokinase 1 bound with 4-{[2-(methylsulfonyl)- 1h-imidazol-1-yl]methyl}-1,3-thiazole
    45% identity, 97% coverage of query (286 bits)

7s4cA Crystal structure of inhibitor-bound galactokinase
    45% identity, 97% coverage of query (286 bits)

7s49A Crystal structure of inhibitor-bound galactokinase
    45% identity, 97% coverage of query (286 bits)

7rclA Crystal structure of adp-bound galactokinase
    45% identity, 97% coverage of query (286 bits)

7ozxB Structure of human galactokinase 1 bound with azepan-1-yl(2,6- difluorophenyl)methanone
    45% identity, 97% coverage of query (286 bits)

6zgyA Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    45% identity, 97% coverage of query (286 bits)

6q91A Structure of human galactokinase 1 bound with 5-chloro-n-isobutyl-2- methoxybenzamide
    45% identity, 97% coverage of query (285 bits)

6q90C Structure of human galactokinase 1 bound with 1-(4-methoxyphenyl)-3- (4-pyridinyl)urea
    44% identity, 97% coverage of query (284 bits)

Q9GKK4 galactokinase (EC 2.7.1.6) from Canis lupus familiaris (see paper)
    45% identity, 97% coverage of query (281 bits)

6zh0A Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    45% identity, 97% coverage of query (281 bits)

1wuuA Crystal structure of human galactokinase complexed with mgamppnp and galactose
    45% identity, 97% coverage of query (279 bits)

6zfhA Structure of human galactokinase in complex with galactose and 2'- (benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'h-spiro[cyclopentane-1,4'- quinazolin]-5'(6'h)-one
    45% identity, 97% coverage of query (278 bits)

6gr2A Structure of human galactokinase in complex with galactose and adp
    45% identity, 97% coverage of query (276 bits)

6zgvD Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    44% identity, 97% coverage of query (272 bits)

CA265_RS06125 galactokinase, -1-phosphate forming (EC 2.7.1.6) from Pedobacter sp. GW460-11-11-14-LB5
    39% identity, 93% coverage of query (268 bits)

6zgwD Structure of human galactokinase 1 bound with (4-chlorophenyl)methyl pyridine-3-carboxylate
    45% identity, 93% coverage of query (268 bits)

6zgzD Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    44% identity, 93% coverage of query (262 bits)

6zgxD Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    44% identity, 93% coverage of query (261 bits)

6qjeD Structure of human galactokinase 1 bound with 4-{[2-(methylsulfonyl)- 1h-imidazol-1-yl]methyl}-1,3-thiazole
    43% identity, 97% coverage of query (258 bits)

6q91D / P51570 Structure of human galactokinase 1 bound with 5-chloro-n-isobutyl-2- methoxybenzamide
    43% identity, 97% coverage of query (251 bits)

Q9K3S8 galactokinase (EC 2.7.1.6) from Streptomyces coelicolor (see paper)
    38% identity, 97% coverage of query (244 bits)

1s4eF / Q9HHB6 Pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium (see paper)
    37% identity, 94% coverage of query (242 bits)

GAL1_PYRFU / Q9HHB6 Galactokinase; Galactose kinase; EC 2.7.1.6 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 3 papers)
    37% identity, 94% coverage of query (242 bits)

galK / CAB44216.1 galactokinase from Lactococcus lactis (see paper)
    37% identity, 97% coverage of query (220 bits)

Q9R7D7 Galactokinase; Galactose kinase; EC 2.7.1.6 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    37% identity, 97% coverage of query (219 bits)

GAL1_PYRHO / O58107 Galactokinase; Galactose kinase; EC 2.7.1.6 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
2deiA / O58107 Crystal structure of galaktokinase from pyrococcus horikoshii with amp-pnp and galactose
    32% identity, 94% coverage of query (218 bits)

1pieA / Q9R7D7 Crystal structure of lactococcus lactis galactokinase complexed with galactose (see paper)
    37% identity, 97% coverage of query (216 bits)

2dejA Crystal structure of galaktokinase from pyrococcus horikoshii with amp-pn and galactose
    32% identity, 94% coverage of query (209 bits)

6teqA / B7GUI0 Crystal structure of a galactokinase from bifidobacterium infantis in complex with 2-deoxy-2-fluoro-galactose (see paper)
    34% identity, 92% coverage of query (192 bits)

6terA Crystal structure of a galactokinase from bifidobacterium infantis in complex with galactose
    34% identity, 92% coverage of query (192 bits)

6tepA Crystal structure of a galactokinase from bifidobacterium infantis in complex with adp
    34% identity, 92% coverage of query (187 bits)

Build an alignment

Build an alignment for 14882 and 41 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

2a2cA X-ray structure of human n-acetyl galactosamine kinase complexed with mg-adp and n-acetyl galactosamine 1-phosphate
    28% identity, 98% coverage of query (140 bits)

2a2dA / Q01415 X-ray structure of human n-acetyl galactosamine kinase complexed with mn-amppnp and n-acetyl glactosamine (see paper)
    27% identity, 98% coverage of query (137 bits)

GALK2_HUMAN / Q01415 N-acetylgalactosamine kinase; GalNAc kinase; Galactokinase 2; EC 2.7.1.157 from Homo sapiens (Human) (see paper)
Q01415 N-acetylgalactosamine kinase (EC 2.7.1.157) from Homo sapiens (see 2 papers)
    27% identity, 98% coverage of query (136 bits)

GALK / B6V3B9 galactokinase (EC 2.7.1.6) from Cucumis melo (see paper)
    26% identity, 97% coverage of query (129 bits)

GALAK_ARATH / Q8VYG2 Galacturonokinase; D-galacturonic acid-1-P kinase; EC 2.7.1.44 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    27% identity, 89% coverage of query (115 bits)

1s4eG / Q9HHB6 Pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium (see paper)
    27% identity, 91% coverage of query (98.6 bits)

Q4DF18 galactokinase (EC 2.7.1.6) from Trypanosoma cruzi (see paper)
    27% identity, 93% coverage of query (94.7 bits)

Q4DFH6 galactokinase (EC 2.7.1.6) from Trypanosoma cruzi (see paper)
    25% identity, 90% coverage of query (83.2 bits)

hddA / Q9AGY8 D-glycero-α-D-manno-heptose-7-phosphate kinase (EC 2.7.1.168) from Aneurinibacillus thermoaerophilus (see paper)
HDDA_ANETH / Q9AGY8 D-glycero-alpha-D-manno-heptose 7-phosphate kinase; D-alpha-D-heptose 7-phosphate kinase; EC 2.7.1.168 from Aneurinibacillus thermoaerophilus (see paper)
Q9AGY8 D-glycero-alpha-D-manno-heptose-7-phosphate kinase (EC 2.7.1.168) from Aneurinibacillus thermoaerophilus (see 2 papers)
    24% identity, 77% coverage of query (62.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory