Searching for up to 100 curated homologs for 15012 FitnessBrowser__Keio:15012 (321 a.a.)
Found high-coverage hits (≥70%) to 90 curated proteins.
Removed hits that are identical to the query, leaving 89
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1f6mA / P0A9P4 Crystal structure of a complex between thioredoxin reductase, thioredoxin, and the NADP+ analog, aadp+ (see paper)
100% identity, 100% coverage of query (657 bits)
1tdfA Crystal structure of escherichia coli thioredoxin reductase refined at 2 angstrom resolution: implications for a large conformational change during catalysis
100% identity, 98% coverage of query (649 bits)
5vt3B High resolution structure of thioredoxin-disulfide reductase from vibrio vulnificus cmcp6 in complex with NADP and fad
80% identity, 99% coverage of query (532 bits)
5u63B / P43788 Crystal structure of putative thioredoxin reductase from haemophilus influenzae
76% identity, 98% coverage of query (498 bits)
GLCAL_PSEFL / Q93HX6 Glucosaminate ammonia-lyase; D-glucosaminate dehydratase alpha-subunit; GlcNA-DH alpha subunit; GlcNADH-alpha; EC 4.3.1.9 from Pseudomonas fluorescens (see paper)
Q93HX6 glucosaminate ammonia-lyase (EC 4.3.1.9) from Pseudomonas fluorescens (see paper)
71% identity, 100% coverage of query (475 bits)
4jnqA / Q8YID2 Crystal structure of a thioredoxin reductase from brucella melitensis
54% identity, 97% coverage of query (331 bits)
5uthA / A0R7I9 Crystal structure of thioredoxin reductase from mycobacterium smegmatis in complex with fad
51% identity, 95% coverage of query (305 bits)
8ccmA Crystal structure of mycobacterium smegmatis thioredoxin reductase in complex with compound 2-06
51% identity, 95% coverage of query (305 bits)
8cclA Crystal structure of mycobacterium smegmatis thioredoxin reductase in complex with fragment f2x-entry a09
51% identity, 95% coverage of query (305 bits)
8cckA Crystal structure of mycobacterium smegmatis thioredoxin reductase in complex with fragment f2x-entry h07
51% identity, 95% coverage of query (305 bits)
8ccjA Crystal structure of mycobacterium smegmatis thioredoxin reductase in complex with NADPH
51% identity, 95% coverage of query (305 bits)
B0SKV7 thioredoxin-disulfide reductase (EC 1.8.1.9) from Leptospira biflexa serovar Patoc (see paper)
51% identity, 96% coverage of query (298 bits)
TRXB2_YEAST / P38816 Thioredoxin reductase 2, mitochondrial; EC 1.8.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
50% identity, 97% coverage of query (297 bits)
Q72SB4 thioredoxin-disulfide reductase (EC 1.8.1.9) from Leptospira interrogans serovar Copenhageni (see paper)
50% identity, 96% coverage of query (297 bits)
3itjB / P29509 Crystal structure of saccharomyces cerevisiae thioredoxin reductase 1 (trr1) (see paper)
50% identity, 97% coverage of query (297 bits)
3d8xA Crystal structure of saccharomyces cerevisiae ndpph dependent thioredoxin reductase 1
50% identity, 97% coverage of query (297 bits)
TRXB1_YEAST / P29509 Thioredoxin reductase 1; TR; TrxR; Thioredoxin peroxidase 1; TPx; Thioredoxin-dependent peroxide reductase 1; EC 1.8.1.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
P29509 thioredoxin-disulfide reductase (EC 1.8.1.9) from Saccharomyces cerevisiae (see paper)
50% identity, 97% coverage of query (296 bits)
A0A0Q3NCX3 thioredoxin-disulfide reductase (EC 1.8.1.9) from Brachypodium distachyon (see paper)
49% identity, 95% coverage of query (295 bits)
7p9eB / A0A2K3E888 Chlamydomonas reinhardtii NADPH dependent thioredoxin reductase 1 domain cs mutant (see paper)
50% identity, 95% coverage of query (293 bits)
2a87A / P9WHH1 Crystal structure of m. Tuberculosis thioredoxin reductase (see paper)
49% identity, 95% coverage of query (292 bits)
TRXB_MYCTU / P9WHH1 Thioredoxin reductase; TR; TRXR; EC 1.8.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
49% identity, 95% coverage of query (292 bits)
TRXB_STRCL / Q05741 Thioredoxin reductase; TRXR; EC 1.8.1.9 from Streptomyces clavuligerus (see 2 papers)
trxB / CAA79940.1 thioredoxin reductase from Streptomyces clavuligerus (see paper)
49% identity, 98% coverage of query (288 bits)
OsNtrC / CAE46765.1 NADPH thioredoxin reductase from Oryza sativa Japonica Group (see paper)
47% identity, 95% coverage of query (288 bits)
TRXB3_ARATH / O22229 NADPH-dependent thioredoxin reductase 3; NTR3; NADPH-dependent thioredoxin reductase C; ANTR-C; AtNTRC; EC 1.8.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O22229 thioredoxin-disulfide reductase (EC 1.8.1.9) from Arabidopsis thaliana (see 9 papers)
48% identity, 95% coverage of query (288 bits)
NTRC_ORYSJ / Q70G58 Thioredoxin reductase NTRC; NADPH-dependent thioredoxin reductase C; OsNTRC; EC 1.8.1.9 from Oryza sativa subsp. japonica (Rice) (see 4 papers)
Q70G58 thioredoxin-disulfide reductase (EC 1.8.1.9) from Oryza sativa (see 2 papers)
47% identity, 95% coverage of query (287 bits)
B9ZYY5 thioredoxin-disulfide reductase (EC 1.8.1.9) from Chlorella vulgaris (see paper)
47% identity, 97% coverage of query (285 bits)
W8VVL6 thioredoxin-disulfide reductase (EC 1.8.1.9) from Euglena gracilis (see paper)
48% identity, 95% coverage of query (284 bits)
W8VNN5 thioredoxin-disulfide reductase (EC 1.8.1.9) from Euglena gracilis (see paper)
46% identity, 97% coverage of query (282 bits)
TRXB_STRCO / P52215 Thioredoxin reductase; TRXR; EC 1.8.1.9 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
trxB / CAA63076.1 thioredoxin reductase (NADPH) from Streptomyces coelicolor (see paper)
48% identity, 97% coverage of query (281 bits)
A6XJ27 thioredoxin-disulfide reductase (EC 1.8.1.9) from Medicago truncatula (see paper)
47% identity, 95% coverage of query (281 bits)
Q8YYV6 thioredoxin-disulfide reductase (EC 1.8.1.9) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
48% identity, 97% coverage of query (281 bits)
TRR1 thioredoxin reductase; EC 1.8.1.9 from Candida albicans (see paper)
49% identity, 96% coverage of query (280 bits)
trxB / CAA07451.1 thioredoxin reductase (NADPH) from Streptomyces coelicolor (see 2 papers)
47% identity, 97% coverage of query (278 bits)
NADPH / AAA64747.1 thioredoxin reductase from Saccharomyces cerevisiae (see paper)
48% identity, 97% coverage of query (276 bits)
trr1 thioredoxin reductase Trr1; EC 1.8.1.9 from Schizosaccharomyces pombe (see 4 papers)
47% identity, 98% coverage of query (275 bits)
Q92375 Thioredoxin reductase; Caffeine resistance protein 4; EC 1.8.1.9 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
47% identity, 98% coverage of query (275 bits)
TRXB2_ARATH / Q39242 Thioredoxin reductase 2; NADPH-dependent thioredoxin reductase 2; NTR2; NADPH-dependent thioredoxin reductase A; AtNTRA; EC 1.8.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q39242 thioredoxin-disulfide reductase (EC 1.8.1.9) from Arabidopsis thaliana (see paper)
46% identity, 97% coverage of query (273 bits)
trxR thioredoxin reductase; EC 1.8.1.9 from Emericella nidulans (see 2 papers)
46% identity, 96% coverage of query (273 bits)
6bpyA / A0A229Y1X4 Aspergillus fumigatus thioredoxin reductase (see paper)
46% identity, 96% coverage of query (272 bits)
5w4cA / J9VRX9 Crystal structure of thioredoxin reductase from cryptococcus neoformans in complex with fad (fo conformation)
47% identity, 96% coverage of query (272 bits)
TRXB_PENCH / P43496 Thioredoxin reductase; EC 1.8.1.9 from Penicillium chrysogenum (Penicillium notatum) (see paper)
45% identity, 96% coverage of query (257 bits)
TRXB1_ARATH / Q39243 Thioredoxin reductase 1, mitochondrial; NADPH-dependent thioredoxin reductase 1; NTR1; NADPH-dependent thioredoxin reductase B; AtNTRB; EC 1.8.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q39243 thioredoxin-disulfide reductase (EC 1.8.1.9) from Arabidopsis thaliana (see 2 papers)
47% identity, 97% coverage of query (256 bits)
1vdcA / Q39243 Structure of NADPH dependent thioredoxin reductase (see paper)
46% identity, 97% coverage of query (252 bits)
2q7vA / Q9RSY7 Crystal structure of deinococcus radiodurans thioredoxin reductase (see paper)
44% identity, 96% coverage of query (251 bits)
4a5lA / C4LW95 Crystal structure of the thioredoxin reductase from entamoeba histolytica (see paper)
43% identity, 95% coverage of query (244 bits)
4a65A Crystal structure of the thioredoxin reductase from entamoeba histolytica with aucn
43% identity, 95% coverage of query (244 bits)
4ccqA Crystal structure of the thioredoxin reductase from entamoeba histolytica with NADP
43% identity, 95% coverage of query (244 bits)
A9LN30 thioredoxin-disulfide reductase (EC 1.8.1.9) from Hordeum vulgare (see paper)
44% identity, 96% coverage of query (243 bits)
2whdB / A9LN30 Barley NADPH-dependent thioredoxin reductase 2 (see paper)
44% identity, 96% coverage of query (243 bits)
4gcmB / P66011 Crystal structure of a thioredoxine reductase (trxb) from staphylococcus aureus subsp. Aureus mu50 at 1.80 a resolution
42% identity, 97% coverage of query (220 bits)
5m5jB / E2RU27 Thioredoxin reductase from giardia duodenalis (see paper)
42% identity, 97% coverage of query (220 bits)
B6YUA8 thioredoxin-disulfide reductase (EC 1.8.1.9) from Thermococcus onnurineus (see paper)
40% identity, 97% coverage of query (216 bits)
7aawA / Q815J1 Thioredoxin reductase from bacillus cereus (see paper)
39% identity, 97% coverage of query (211 bits)
7aawB Thioredoxin reductase from bacillus cereus
39% identity, 97% coverage of query (211 bits)
O50134 thioredoxin-disulfide reductase (EC 1.8.1.9) from Pyrococcus horikoshii (see paper)
39% identity, 97% coverage of query (209 bits)
3r9uA / Q0PBZ1 Thioredoxin-disulfide reductase from campylobacter jejuni.
40% identity, 96% coverage of query (205 bits)
5uwyA The crystal structure of thioredoxin reductase from streptococcus pyogenes mgas5005
38% identity, 96% coverage of query (204 bits)
2q0kA Oxidized thioredoxin reductase from helicobacter pylori in complex with NADP+
36% identity, 95% coverage of query (200 bits)
3ishA / P56431 Crystal structure of helicobacter pylori thioredoxin reductase
36% identity, 95% coverage of query (200 bits)
5mh4A / A2RLJ5 Crystal structure of lactococcus lactis thioredoxin reductase (fr conformation) (see paper)
37% identity, 95% coverage of query (190 bits)
3f8rA Crystal structure of sulfolobus solfataricus thioredoxin reductase b3 in complex with two NADP molecules
37% identity, 95% coverage of query (188 bits)
3f8pD / Q8X236 Structure of sulfolobus solfataricus trxr-b3 (see paper)
36% identity, 95% coverage of query (186 bits)
3f8dA Structure of sulfolobus solfataricus thioredoxin reductase mutant c147a
36% identity, 95% coverage of query (184 bits)
5j60A / Q7NMP6 Structure of a thioredoxin reductase from gloeobacter violaceus (see paper)
36% identity, 96% coverage of query (182 bits)
7jypA / B7ICV3 Structure of thioredoxin reductase from the thermophilic eubacterium thermosipho africanus tcf52b
34% identity, 97% coverage of query (181 bits)
1hyuA / P19480 Crystal structure of intact ahpf (see paper)
36% identity, 95% coverage of query (139 bits)
4ykgA Crystal structure of the alkylhydroperoxide reductase subunit f (ahpf) with NAD+ from escherichia coli
35% identity, 95% coverage of query (136 bits)
4ykfA Crystal structure of the alkylhydroperoxide reductase subunit f (ahpf) with nadh from escherichia coli
35% identity, 95% coverage of query (136 bits)
P35340 Alkyl hydroperoxide reductase subunit F; Alkyl hydroperoxide reductase F52A protein; EC 1.8.1.- from Escherichia coli (strain K12)
35% identity, 95% coverage of query (136 bits)
Build an alignment for 15012 and 69 homologs with ≥ 30% identity
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3ctyB / Q9HJI4 Crystal structure of t. Acidophilum thioredoxin reductase (see paper)
29% identity, 89% coverage of query (127 bits)
5niiB / Q72C27 Crystal structure of the atypical thioredoxin reductase tri from desulfovibrio vulgaris hildenborough (see paper)
30% identity, 95% coverage of query (107 bits)
2zbwB / Q5SL28 Crystal structure of thioredoxin reductase-like protein from thermus thermophilus hb8
30% identity, 93% coverage of query (107 bits)
FENR_THET8 / Q5SL28 Ferredoxin--NADP reductase; FNR; Fd-NADP(+) reductase; EC 1.18.1.2 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
30% identity, 93% coverage of query (107 bits)
6gncA / Q97IU2 Crystal structure of a ferredoxin-flavin thioredoxin reductase from clostridium acetobutylicum at 1.64 a resolution (see paper)
31% identity, 96% coverage of query (102 bits)
5ygqA / Q6N2U4 Crystal structure of ferredoxin NADP+ oxidoreductase from rhodopseudomonas palustris (see paper)
28% identity, 97% coverage of query (93.6 bits)
6gnaA / Q97EM8 Crystal structure of a ferredoxin-flavin thioredoxin reductase from clostridium acetobutylicum at 1.3 a resolution (see paper)
28% identity, 94% coverage of query (93.2 bits)
3lzwA / O05268 Crystal structure of ferredoxin-NADP+ oxidoreductase from bacillus subtilis (form i) (see paper)
27% identity, 97% coverage of query (78.6 bits)
5xhuA / O31475 Crystal structure of ycgt from bacillus subtilis
25% identity, 96% coverage of query (77.4 bits)
8c16D / Q816D9 Crystal structure of asymmetric ferredoxin/flavodoxin NADP+ oxidoreductase 2 (fnr2) h326v mutant from bacillus cereus (see paper)
24% identity, 96% coverage of query (68.6 bits)
8c3mA / Q81IK1 Crystal structure of ferredoxin/flavodoxin NADP+ oxidoreductase 1 (fnr1) v329h mutant from bacillus cereus (see paper)
25% identity, 88% coverage of query (68.6 bits)
4yryD Insights into flavin-based electron bifurcation via the nadh-dependent reduced ferredoxin-NADP oxidoreductase structure
26% identity, 98% coverage of query (58.5 bits)
4ylfB / Q9X1X5 Insights into flavin-based electron bifurcation via the nadh-dependent reduced ferredoxin-NADP oxidoreductase structure (see paper)
26% identity, 98% coverage of query (58.5 bits)
3ab1B / Q8KCB2 Crystal structure of ferredoxin NADP+ oxidoreductase (see paper)
24% identity, 87% coverage of query (56.6 bits)
5jcaL / Q8U195 NADP(h) bound nadh-dependent ferredoxin:nadp oxidoreductase (nfni) from pyrococcus furiosus (see paper)
25% identity, 96% coverage of query (53.9 bits)
5twbA / Q2FEC4 Oxidoreductase iruo in the reduced form (see paper)
26% identity, 97% coverage of query (53.5 bits)
3oc4A / Q833L5 Crystal structure of a pyridine nucleotide-disulfide family oxidoreductase from the enterococcus faecalis v583
23% identity, 88% coverage of query (52.8 bits)
5vj7A / I6V148 Ferredoxin NADP oxidoreductase (xfn) (see paper)
25% identity, 96% coverage of query (45.4 bits)
4fk1C Crystal structure of putative thioredoxin reductase trxb from bacillus anthracis
21% identity, 93% coverage of query (42.7 bits)
4fk1A / A0A6L8PLA6 Crystal structure of putative thioredoxin reductase trxb from bacillus anthracis
21% identity, 93% coverage of query (42.7 bits)
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